Protein Alignment cher and SYNE2

DIOPT Version :10

• Sequence 1: NP_001262659.2
• Gene: cher / 42066
• FlyBaseID: FBgn0014141
• Length: 2577
• Species: Drosophila melanogaster
• Sequence 2: XP_011534876.1
• Gene: SYNE2 / 23224
• HGNCID: 17084
• Length: 6936
• Species: Homo sapiens
• Alignment Length: 2725
• Identity: 498/2725 - (18%)
• Similarity: 880/2725 - (32%)
• Gaps: 978/2725 - (35%)

  Fly   159 EGQQADQYEENFDEDMEAERDLAEDAQWKKIQQNTFTRWANEHL--KTIDRSINNLETDLSDGLR 221
            |.:|.....::....::||:   ||.|.|     .||.|.|..|  .|....|::|.||:..|..
Human    10 EDEQGSWGIDDLHISLQAEQ---EDTQKK-----AFTCWINSQLARHTSPSVISDLFTDIKKGHV 66

  Fly   222 LIALIEVLSQKRMPKYNKRPTFRSQKLENVSVALKFLQDEGIKIVNIDSSDIVDCKLKLILGLIW 286
            |:.|:||||.:::|:.....||:.:  .|:..||.||::..||::||..:||:|....:||||||
Human    67 LLDLLEVLSGQQLPRDKGSNTFQCR--INIEHALTFLRNRSIKLINIHVTDIIDGNPSIILGLIW 129

  Fly   287 TLILHYSI-----------SMPMWDGEDDKQLNGSGHTP---------------KQRLLNWIH-- 323
            |:|||:.|           :.|..|.......:.:...|               ::.||.|..
Human   130 TIILHFHIEKLAQTLSCNYNQPSLDDVSVVDSSPASSPPAKKCSKVQARWQMSARKALLLWAQEQ 194

  Fly   324 -AKIPDLPINNFTNDWTTGKAVGALVDACAPGLCPDWELWDPKDAVQNASEAMGLADDWLNVRQL 387
             |....:.:.:|.:.|..|.|..|::.|..|.|. |.:....:....|..||..:|:..|.:.:|
Human   195 CATYESVNVTDFKSSWRNGMAFLAIIHALRPDLI-DMKSVKHRSNKDNLREAFRIAEQELKIPRL 258

  Fly   388 IKPEELVNPNVDEQSMMTYLSQYPNSKLKTGAPLRPKTNPNSIPPPRVRAYGPGIEPIGPVVGAP 452
            ::||::...:.||:|:|||::|:  .:....||                  |.|.|..|.|..|.
Human   259 LEPEDVDVVDPDEKSIMTYVAQF--LQYSKDAP------------------GTGEEAQGKVKDAM 303

  Fly   453 ANFT----------------------------VETFSAGKGS-VDV-DIQGPNGEIEK------- 480
            ...|                            :|:|:..|.| :|| .|:....|::|
Human   304 GWLTLQKEKLQKLLKDSENDTYFKKYNSLLSFMESFNEEKKSFLDVLSIKRDLDELDKDHLQLRE 368

  Fly   481 ---------------------------------------ADVRFNND---------KNLTYTVSY 497
                                                   .|:..:.|         :.:|...|.
Human   369 AWDGLDHQINAWKIKLNYALPPPLHQTEAWLQEVEELMDEDLSASQDHSQAVTLIQEKMTLFKSL 433

  Fly   498 IPKSEGSHKVAVKFSGRDIPKSPFPVKVEGHAGDASKVKVTGPGIQPNGVTIKKPTFFDILAKDA 562
            :.:.|....:.:.|..:|          |.|.          |.:.||.:...|....:||.|..
Human   434 MDRFEHHSNILLTFENKD----------ENHL----------PLVPPNKLEEMKRRINNILEKKF 478

  Fly   563 GRGVPEVIIIDPANHKTSVAAKVRQLEN--DTWRCEYVTALQGLHSVNVFYAGTPIPNSPFPVKV 625
                  :::::...:|..|...|.::::  |.|..:|.:.    .||.:.
Human   479 ------ILLLEFHYYKCLVLGLVDEVKSKLDIWNIKYGSR----ESVELL--------------- 518

  Fly   626 APLSDARKVRASGRGLQATGVRVGDDADF----KIYTEGAGEGEPEVRVIGPGGMNQNVMQSKVD 686
              |.|..|.......|...      |..|    :||...|||.:         .:|:..|..|.|
Human   519 --LEDWHKFIEEKEFLARL------DTSFQKCGEIYKNLAGECQ---------NINKQYMMVKSD 566

  Fly   687 GNTYECHYYPTKEGRYVIMVTFA-----------------GQEVAKSPFEVKVGPKKESSIVAYG 734
            ...|..:.|..|.....::..:|                 .:|:.:.|||.
Human   567 VCMYRKNIYNVKSTLQKVLACWATYVENLRLLRACFEETKKEEIKEVPFET-------------- 617

  Fly   735 PGLSSGVIGYPAAFVVETNGETGALGFTVAGPSQAEIECHDNGDGSALVKYHPTAVGEYAVHILC 799
                          :.:.|.|...|                |..|:.||:.....||
Human   618 --------------LAQWNLEHATL----------------NEAGNFLVEVSNDVVG-------- 644

  Fly   800 DNEDIPK-----SPFIAQILPRTDFH---PELVKASG-PGLEKNGVTINQPTSFTVDPSKAGNAP 855
              ..|.|     :....:::.:|...   |.::|... |..:.:|..:::....||:
Human   645 --SSISKELRRLNKRWRKLVSKTQLEMNLPLMIKKQDQPTFDNSGNILSKEEKATVE-------- 699

  Fly   856 LDVVVQDVFGTKLPVELKNNPDGTKKVTYTPTSGVPHTVEVNYGGVSTPNSPHRVYVGVPVDAAK 920
                    |.|.:.|||..|.:...|      :|..|..|         |......:.|..|..|
Human   700 --------FSTDMSVELPENYNQNIK------AGEKHEKE---------NEEFTGQLKVAKDVEK 741

  Fly   921 VQAFGPWLQPGVRPNAATHFNVDAREAGDAELKVKIIHEETKIEVPCRIIDNEDNTYSVE----- 980
            :                    :...|..:||.|              .::|.:|...|:|
Human   742 L--------------------IGQVEIWEAEAK--------------SVLDQDDVDTSMEESLKH 772

  Fly   981 VIPPSKGAYTTTMTYGGQRVPLGEKVVVEQTVDVSKIKVDGLEPTAPLNSLQQFR-IITHGLPKA 1044
            :|  :||:....:              :.::.|:.::.:..      ::|.:.|: ::|.|| :|
Human   773 LI--AKGSMFDEL--------------MARSEDMLQMDIQN------ISSQESFQHVLTTGL-QA 814

  Fly  1045 DLAVTITSPSGNRIKAHIIPTAEGF--LVNFTP------------TQLGEYLLSICFGGTPITPR 1095
            .:     ..:..:::.:::......  |.:.:|            .:|..|::
Human   815 KI-----QEAKEKVQINVVKLIAALKNLTDVSPDLDIRLKMEESQKELESYMM------------ 862

  Fly  1096 PFRLQCLTGSDSNKVQAFGPGLERGIVGQPAEFMI--DTRGAGQGGLGVTVEGPCEAAINCRDNG 1158
              |.|.|.|      |...||   .::.:..|.:|  :|:...:         ..:|....::|
Human   863 --RAQQLLG------QRESPG---ELISKHKEALIISNTKSLAK---------YLKAVEELKNN- 906

  Fly  1159 DGTCNVAYLPTEAGDYTVNITFNERHITG---SPFQPLIVPVPNLKNTRVSGIGIQPHGVIMNAA 1220
                     .||  |..:::....|.:..   |....|.:.|..||
Human   907 ---------VTE--DIKMSLEEKSRDVCAKWESLHHELSLYVQQLK------------------- 941

  Fly  1221 TDFMVDMSKVGSNIDSGKLSCAIFDPMGHVLPSK--IVQGPTDDIFRIMYTPF-EAG-----RHT 1277
                :|       |:.||||..|......:...|  |.:|.|..:.:.....| |.|     .|.
Human   942 ----ID-------IEKGKLSDNILKLEKQINKEKKLIRRGRTKGLIKEHEACFSEEGCLYQLNHH 995

  Fly  1278 IEL---MYDNIPVPGSPFVVNVKSGCDPAR-CKAYGPGLEKGLT---------------NQKNKF 1323
            :|:   :.:.:|        :.||..:..| .|.|...:|:.|.               ..||:.
Human   996 MEVLRELCEELP--------SQKSQQEVKRLLKDYEQKIERLLKCASEIHMTLQPTAGGTSKNEG 1052

  Fly  1324 TVETKGAGNGGLSLAIEGPSEAKMTCTDNRDGSCDVDYLATDPGEYDITIRFADKHIPGSPFRVL 1388
            |: |.....||     :..|||....:||:..:    ..|.:|     |::|:    ..|..|.|
Human  1053 TI-TTSENRGG-----DPHSEAPFAKSDNQPST----EKAMEP-----TMKFS----LASVLRPL 1098

  Fly  1389 VEETVDPSKVKVYGPGIEHGQVRESVPTFFNVDVGEAGPGRIAVKLTNSE-GIPVDNLRVEDK-G 1451
            .||::   ..|.|...|  ..:.|...|:.::         :...|.|:: .|..|....||: .
Human  1099 QEESI---MEKDYSASI--NSLLERYDTYRDI---------LEHHLQNNKFRITSDFSSEEDRSS 1149

  Fly  1452 NCIYAVHYVPPKAGSVLTCQVKFSEVEVPCSPFVMTVFPKSEPTKVKVKGVNEKKKTPASLPAEF 1516
            :|:                |.|.::::|                        .|.:|.|.. .||
Human  1150 SCL----------------QAKLTDLQV------------------------IKNETDARW-KEF 1173

  Fly  1517 EIDTKQAGQADINVAIKNPKGKAMQPRLEEVSTGTYVVSFVPDECGTYQCSIKYGDKEIEGS-PF 1580
            ||         |::.::|......:|             ||..|..|    :|..::|::.: ..
Human  1174 EI---------ISLKLENHVNDIKKP-------------FVIKERDT----LKERERELQMTLNT 1212

  Fly  1581 KLEAFPTGEAKKCKLVEQAPKIQTSGSQSHLKVDAREAGDGAVTCKITNKAGSEIVDIDVIE--- 1642
            ::|:..|  |.:..|..:...:...||...|...|.:              |..::|.|.|.
Human  1213 RMESLET--ALRLVLPVEKASLLLCGSDLPLHKMAIQ--------------GFHLIDADRIYQHL 1261

  Fly  1643 ---KDGF---FDILYALNDPGDYDINVKFGGKDIPNGSFSIKAVESIEQYSHSEYIEEHTTKVVQ 1701
               :|..   .:|...|.:||::.:      |::  ..|.:.|:::|               :::
Human  1262 RNIQDSIAKQIEICNRLEEPGNFVL------KEL--HPFDLHAMQNI---------------ILK 1303

  Fly  1702 QTTQSELVN---GKSEITYRSVAFEKLPLPTTGGNVTAEVRMPSGKVDKPVIQDNRDGTVSVKYD 1763
            ..||.|.:|   .:||.|.:  |.|..........::||........|..|.|:|   |::||
Human  1304 YKTQFEGMNHRVQRSEDTLK--ALEDFLASLRTAKLSAEPVTDLSASDTQVAQEN---TLTVK-- 1361

  Fly  1764 PREEGSHELV---VKYNGEPVQGSPFKFH-----VDSITSGYVTAYGPGL--THGVTGEPANFTI 1818
             .:||...|:   .|:..:.::.....|.     .|:.....:.|:...|  |||. |....||.
Human  1362 -NKEGEIHLMKDKAKHLDKCLKMLDMSFKDAERGDDTSCENLLDAFSIKLSETHGY-GVQEEFTE 1424

  Fly  1819 STKGASA-----GGLTMAVEGPSKADINYHDNKDGTVSVQYLPTAPG----------------EY 1862
            ..|...|     ..|...::     |:....:|.|...    ||.|.                ||
Human  1425 ENKLLEACIFKNNELLKNIQ-----DVQSQISKIGLKD----PTVPAVKHRKKSLIRLDKVLDEY 1480

  Fly  1863 QVSVRFGDKHIKGSPYFAKITGEGRKR--NQISVGSCSEVTMPGDIT------------------ 1907
            :...|...:.....|:|.    :||::  ||    .|....:..:.|
Human  1481 EEEKRHLQEMANSLPHFK----DGREKTVNQ----QCQNTVVLWENTKALVTECLEQCGRVLELL 1537

  Fly  1908 ----------------DDDLRALNASIQAPSGLEEPCFLKRMPTGNIGISFTPREIGEHLVSVKR 1956
                            ::.:.:|.||......|:     ||:..    |.....|..|||..|.:
Human  1538 KQYQNFKSILTTLIQKEESVISLQASYMGKENLK-----KRIAE----IEIVKEEFNEHLEVVDK 1593

  Fly  1957 LGKHINNSPF---KVTVCEREVGDAKKVKVSGTGLKEGQTHADNIFSVDTR------NAG----- 2007
            :.:...|..|   |:...|....:           ||.....|....::.:      |.|
Human  1594 INQVCKNLQFYLNKMKTFEEPPFE-----------KEANIIVDRWLDINEKTEDYYENLGRALAL 1647

  Fly  2008 ----FGGLSVSIEGPSKA----EI-QCTDKDDGTLN-----ISYKPTEPGYYIVNLKFADHHVEG 2058
                |...:|..|...||    |: |.|::|...|.     ...|.:|....:..::|.....|
Human  1648 WDKLFNLKNVIDEWTEKALQKMELHQLTEEDRERLKEELQVHEQKTSEFSRRVAEIQFLLQSSE- 1711

  Fly  2059 SPFTVKVAGEGSNRKREKIQR----ERDAVPITEIGSQCKLTFKMP------GITSFDLAACVTS 2113
            .|..::|.......|.|.:|:    |.:...::  ||..:|...:.      |:|...|.|  .|
Human  1712 IPLELQVMESSILNKMEHVQKCLTGESNCHALS--GSTAELREDLDQAKTQIGMTESLLKA--LS 1772

  Fly  2114 PSNVTE-DAEIQEVEDGL----YAVHFVPKELGVHT--VSVRYSEMHIPGSPFQFTVGPLRDSGS 2171
            ||:..| ..:::|::..:    :::..:..::|..|  :|....:.......|......|:|..|
Human  1773 PSDSLEIFTKLEEIQQQILQQKHSMILLENQIGCLTPELSELKKQYESVSDLFNTKKSVLQDHFS 1837

  Fly  2172 HLVKAGGSGLERGVVGEAAEFNVWTREAGGGSLAISVE-----GPSKADIEFKDRKDGSCDVSYK 2231
            .|:.           .:...||.|.     .::.::::     ..:|..:|.|.:|     :|..
Human  1838 KLLN-----------DQCKNFNDWF-----SNIKVNLKECFESSETKKSVEQKLQK-----LSDF 1881

  Fly  2232 VTEPG------EYRVGLKFNDRHIPDSPFKVYVSPDAGDAHKLE-VQQFPQGNIQ--ADAPYQFM 2287
            :|..|      :....||...:|:|.:..|..:|...|...:|| ::...|...:  .|:..|.:
Human  1882 LTLEGRNSKIKQVDSVLKHVKKHLPKAHVKELISWLVGQEFELEKMESICQARAKELEDSLQQLL 1946

  Fly  2288 --------VRKNGAKGELDAKIVAPSGTDDDCFIQVIDGEMYSVRFYPRENGIHAIHVKFNGVHI 2344
                    :||.....|...|.:...|...:.|.|.:..:        ||        :|.
Human  1947 RLQDDHRNLRKWLTNQEEKWKGMEEPGEKTELFCQALARK--------RE--------QFE---- 1991

  Fly  2345 PDSPFRIKVGKDVADPAAVHASGNGLDEVKTGHKADFIIN-TCNAGVGTLAVSIDGPSKVAMDCT 2408
                             :|....|.|.|.....:.:.|:. ||         .:|....:....:
Human  1992 -----------------SVAQLNNSLKEYGFTEEEEIIMEATC---------LMDRYQTLLRQLS 2030

  Fly  2409 EVEEGYKVRYTPLLPGE------------HYITVKYNNMHIVGSPFKVNATGDKLADEGAQETST 2461
            |:||..|     |||.|            |:|.....::.::.|     :.|....:|..|:...
Human  2031 EIEEEDK-----LLPTEDQSFNDLAHDVIHWIKEIKESLMVLNS-----SEGKMPLEERIQKIKE 2085

  Fly  2462 VI---------VETVQKVAKGGK----------------NTGVHL-PTFKSDASKVVSKG 2495
            :|         :||:.|.|:..:                || :|| .|:.|...|::.:|
Human  2086 IILLKPEGDARIETIMKQAESSEAPLVQKTLTDISNQWDNT-LHLASTYLSHQEKLLLEG 2144

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cher	NP_001262659.2	CH_dFLNA-like_rpt1	175..297	CDD:409160	49/134 (37%)
		CH_dFLNA-like_rpt2	298..415	CDD:409164	30/134 (22%)
		IG_FLMN	432..527	CDD:214720	23/179 (13%)
		IG_FLMN	532..627	CDD:214720	15/96 (16%)
		IG_FLMN	631..724	CDD:214720	21/113 (19%)
		IG_FLMN	728..815	CDD:214720	11/91 (12%)
		IG_FLMN	821..913	CDD:214720	17/92 (18%)
		IG_FLMN	918..1001	CDD:214720	12/87 (14%)
		Filamin	1012..1098	CDD:395505	11/100 (11%)
		IG_FLMN	1109..1196	CDD:214720	14/91 (15%)
		Filamin	1197..1293	CDD:395505	20/106 (19%)
		IG_FLMN	1302..1392	CDD:214720	24/105 (23%)
		IG_FLMN	1395..1490	CDD:214720	15/96 (16%)
		IG_FLMN	1494..1587	CDD:214720	17/93 (18%)
		IG_FLMN	1606..1682	CDD:214720	16/84 (19%)
		IG_FLMN	<1731..1791	CDD:214720	14/67 (21%)
		IG_FLMN	1797..1884	CDD:214720	22/109 (20%)
		IG_FLMN	1978..2067	CDD:214720	21/113 (19%)
		Filamin	<2111..2159	CDD:395505	8/54 (15%)
		IG_FLMN	2172..2260	CDD:214720	16/98 (16%)
		IG_FLMN	2265..2354	CDD:214720	15/99 (15%)
		IG_FLMN	2360..2448	CDD:214720	19/100 (19%)
		IG_FLMN	2488..2577	CDD:214720	2/8 (25%)
SYNE2	XP_011534876.1	CH_SYNE2_rpt1	28..138	CDD:409091	47/119 (39%)
		CH_SYNE2_rpt2	178..286	CDD:409093	28/110 (25%)
		PRK03918	<1418..2014	CDD:235175	120/695 (17%)
		PRK03918	<1868..>2369	CDD:235175	64/339 (19%)
		SMC_N	<2338..2712	CDD:481474
		CCDC158	2805..>3389	CDD:464943
		SMC_N	<3656..>3950	CDD:481474
		SMC_N	<3811..4113	CDD:481474
		SMC_prok_B	<4496..5321	CDD:274008
		SPEC	4945..5169	CDD:238103
		SPEC	5063..5276	CDD:238103
		SMC_prok_B	5123..>5875	CDD:274008
		SPEC	5178..5384	CDD:413338
		SPEC	5919..6133	CDD:238103
		SPEC	6137..6350	CDD:238103
		SPEC	6590..6813	CDD:238103
		KASH	<6905..6936	CDD:463142