Protein Alignment cher and Plec

DIOPT Version :10

• Sequence 1: NP_001262659.2
• Gene: cher / 42066
• FlyBaseID: FBgn0014141
• Length: 2577
• Species: Drosophila melanogaster
• Sequence 2: NP_001157012.1
• Gene: Plec / 18810
• MGIID: 1277961
• Length: 4691
• Species: Mus musculus
• Alignment Length: 286
• Identity: 96/286 - (33%)
• Similarity: 142/286 - (49%)
• Gaps: 51/286 - (17%)

  Fly   155 PARQEGQ--QADQYEENFDE--------------------DMEAERDLAEDAQWKKIQQNTFTRW 197
            |||:|.|  :..:.||...|                    ....|||        ::|:.|||:|
Mouse   138 PAREERQVYRRKEREEGAPETPVVSATTVGTLARPGPEPAPATDERD--------RVQKKTFTKW 194

  Fly   198 ANEHL-----KTIDRSINNLETDLSDGLRLIALIEVLSQKRMPKYNKRPTFRSQKLENVSVALKF 257
            .|:||     ....|.|::|..||.||..||:|:||||...:|:...|  .|..||:||.:||.:
Mouse   195 VNKHLIKHWRAEAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGR--MRFHKLQNVQIALDY 257

  Fly   258 LQDEGIKIVNIDSSDIVDCKLKLILGLIWTLILHYSISMPMWDGEDDKQLNGSGH--TPKQRLLN 320
            |:...:|:|||.:.||.|...||.||||||:|||:.||        |.|::|...  |.|::||.
Mouse   258 LRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQIS--------DIQVSGQSEDMTAKEKLLL 314

  Fly   321 WIHAKI---PDLPINNFTNDWTTGKAVGALVDACAPGLCPDWELWDPKDAVQNASEAMGLADDWL 382
            |....:   ..|..:|||..|..|:...|::....|.|. |......:..::|..:|..:|:..|
Mouse   315 WSQRMVEGYQGLRCDNFTTSWRDGRLFNAIIHRHKPMLI-DMNKVYRQTNLENLDQAFSVAERDL 378

  Fly   383 NVRQLIKPEELVNPNVDEQSMMTYLS 408
            .|.:|:.||::..|..||:|::||:|
Mouse   379 GVTRLLDPEDVDVPQPDEKSIITYVS 404

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cher	NP_001262659.2	CH_dFLNA-like_rpt1	175..297	CDD:409160	55/126 (44%)
		CH_dFLNA-like_rpt2	298..415	CDD:409164	33/116 (28%)
		IG_FLMN	432..527	CDD:214720
		IG_FLMN	532..627	CDD:214720
		IG_FLMN	631..724	CDD:214720
		IG_FLMN	728..815	CDD:214720
		IG_FLMN	821..913	CDD:214720
		IG_FLMN	918..1001	CDD:214720
		Filamin	1012..1098	CDD:395505
		IG_FLMN	1109..1196	CDD:214720
		Filamin	1197..1293	CDD:395505
		IG_FLMN	1302..1392	CDD:214720
		IG_FLMN	1395..1490	CDD:214720
		IG_FLMN	1494..1587	CDD:214720
		IG_FLMN	1606..1682	CDD:214720
		IG_FLMN	<1731..1791	CDD:214720
		IG_FLMN	1797..1884	CDD:214720
		IG_FLMN	1978..2067	CDD:214720
		Filamin	<2111..2159	CDD:395505
		IG_FLMN	2172..2260	CDD:214720
		IG_FLMN	2265..2354	CDD:214720
		IG_FLMN	2360..2448	CDD:214720
		IG_FLMN	2488..2577	CDD:214720
Plec	NP_001157012.1	Globular 1. /evidence=ECO:0000250	1..1478		96/286 (34%)
		S10_plectin	7..99	CDD:427337
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	113..161		8/22 (36%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	167..186		3/26 (12%)
		Actin-binding	181..411		88/243 (36%)
		CH_PLEC-like_rpt1	184..293	CDD:409037	51/118 (43%)
		CH_PLEC_rpt2	306..411	CDD:409087	30/100 (30%)
		SPEC	667..761	CDD:197544
		SPEC	763..941	CDD:238103
		SH3_10	938..1004	CDD:407754
		Required for interaction with intermediate filament proteins. /evidence=ECO:0000250|UniProtKB:Q15149	963..4572
		Spectrin_like	1039..1116	CDD:465730
		Smc	<1161..>1706	CDD:440809
		Central fibrous rod domain. /evidence=ECO:0000250	1479..2762
		Smc	1496..>2118	CDD:440809
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1626..1653
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1801..1835
		PTZ00121	<1867..2714	CDD:173412
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2100..2141
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2223..2317
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2675..2728
		Globular 2. /evidence=ECO:0000250	2763..4691
		Plectin	2835..2873	CDD:459901
		Plectin	2873..2911	CDD:459901
		PLEC	2910..2946	CDD:197605
		Plectin	2949..2987	CDD:459901
		PLEC	3161..3198	CDD:197605
		Plectin	3201..3239	CDD:459901
		PLEC	3238..3274	CDD:197605
		Plectin	3277..3315	CDD:459901
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	3312..3338
		Plectin	3494..3532	CDD:459901
		Plectin	3532..3570	CDD:459901
		PLEC	3569..3600	CDD:197605
		Plectin	3608..3646	CDD:459901
		PLEC	3828..3864	CDD:197605
		Plectin	3867..3905	CDD:459901
		PLEC	3904..3940	CDD:197605
		Plectin	3943..3981	CDD:459901
		Required for interaction with type2 keratins, DES and VIM. /evidence=ECO:0000269|PubMed:24940650	3954..4291
		PLEC	4070..4107	CDD:197605
		Plectin	4110..4148	CDD:459901
		Plectin	4186..4224	CDD:459901
		Binding to intermediate filaments. /evidence=ECO:0000250	4257..4307
		Plectin	<4287..4315	CDD:459901
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	4387..4420
		PLEC	4419..4452	CDD:197605
		Plectin	4455..4493	CDD:459901
		Required for efficient interaction with KRT5 and KRT14 heterodimers. /evidence=ECO:0000269|PubMed:24940650	4503..4572
		Plectin	4531..4569	CDD:459901
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	4618..4691
		4 X 4 AA tandem repeats of G-S-R-X	4632..4647