DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment cher and fln-1

DIOPT Version :9

Sequence 1:NP_001262659.2 Gene:cher / 42066 FlyBaseID:FBgn0014141 Length:2577 Species:Drosophila melanogaster
Sequence 2:NP_001294364.1 Gene:fln-1 / 176855 WormBaseID:WBGene00022048 Length:2259 Species:Caenorhabditis elegans


Alignment Length:2560 Identity:879/2560 - (34%)
Similarity:1284/2560 - (50%) Gaps:441/2560 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly   154 QPARQEGQQADQYEENFDEDMEAERDLAEDAQWKKIQQNTFTRWANEHLKTIDRSINNLETDLSD 218
            ||.|     .||.|    |.:.|.|.  :||:||.|||||||||...||:....:|.:||||.||
 Worm     3 QPKR-----LDQEE----EVVPAIRH--DDAEWKIIQQNTFTRWVKNHLQKAGETIESLETDFSD 56

  Fly   219 GLRLIALIEVLSQKRMPKYNKRPTFRSQKLENVSVALKFLQ-DEGIKIVNIDSSDIVDCKLKLIL 282
            ||:||||.:|||.|.:.|:||:..||||||||||:||.|.| :|.|||:||||:.|||...||||
 Worm    57 GLKLIALAQVLSHKNVGKFNKKVAFRSQKLENVSLALNFFQNEENIKIINIDSTHIVDHNKKLIL 121

  Fly   283 GLIWTLILHYSISMPMWDGEDDKQLNGSGHTPKQRLLNWIHAKIP--DLPINNFTNDWTTGKAVG 345
            ||:|||||||||||. |..|..:..:....||||:|||||..::|  .:||:|||:||..|.|:|
 Worm   122 GLVWTLILHYSISMG-WIQEKREDGDNKEETPKQKLLNWIRNRLPVSGMPISNFTSDWNDGVALG 185

  Fly   346 ALVDACAPGLCPDWELWDPKDAVQNASEAMGLADDWLNVRQLIKPEELVNPNVDEQSMMTYLSQY 410
            |||::.|||...|||.|.|.||::|..:||..|.|.|.|..||.|.|:::|.:||.|:||||||:
 Worm   186 ALVNSMAPGALEDWENWSPNDALENTEKAMKSAQDLLKVAPLIAPAEMIHPEIDEMSVMTYLSQF 250

  Fly   411 PNSKLKTGAPLRPKTNPNSIPPPRVRAYGPGIEPIGPVVGAPANFTVETFSAG---KGSV-DVDI 471
            |.:|     |:        |..|:|:|....::.| ..|..|..|.::....|   |.|: |.|.
 Worm   251 PATK-----PI--------IMKPKVQATISNLDKI-LQVNDPREFDLKLSRDGFKPKVSIRDEDG 301

  Fly   472 QGPNGEIEKADVRFNNDKNLTYTVSYIPKSEGSHKVAV------KFSGRDIPKSPFPVKVEGHAG 530
            |..:..::|.:     ||...|.|.:.|...|...|.|      .|..:.||::....:|...|.
 Worm   302 QDIHLSLKKVE-----DKENAYKVKFTPTKIGFIHVDVAANDVHTFETQTIPEASVICQVVPIAR 361

  Fly   531 --DASKVKVTGPGIQPNGVTIKKPTFFDILAKDAGRGVPEVIIIDPA--NHKTSVAAKVRQLEND 591
              |.:|....|..::           |.::  ||..|..|.|::||.  .|:..:.......|:.
 Worm   362 LLDYNKTAKVGDDVK-----------FAVV--DAIEGPVEAIVVDPTGKEHRMVILDGTSPGEHS 413

  Fly   592 TWRCEYVTALQGLHSVNVFYAGTPIPNSPFPVKVAPLSDARKVRASGRGLQATGVRVGDDADFKI 656
               .||.....||||||||:...|:..||||::..|   ....:..|||:...|:|..|.....:
 Worm   414 ---FEYKIPCIGLHSVNVFHKKLPLTGSPFPLRGKP---KNSFKVWGRGIAPEGIRKNDVVGVHV 472

  Fly   657 YT----EGAGEGEPEVRVIGPG---------GMNQNVMQSKVDGNTYECHYYPTK-EGRYVIMVT 707
            .:    |........:.|:.|.         |.|.       :..:.:..|.|.: .....::|.
 Worm   473 ESLDPEENIANANISLEVLKPSDGSHLPVSVGYND-------ESQSMDFEYSPKQAPDDLEVLVK 530

  Fly   708 FAGQEVAKSPFEVKVGPKKESSIVAYGPGLSSGVIGYPAAFVVETNGETGALGFTVAGPSQAEIE 772
            .|| ||.:| .::.|.|:..|.|.|:|.||..|::..|..|.||.|||:..|.|.|.|||:|||.
 Worm   531 VAG-EVIES-HKIHVAPESSSKIRAFGAGLEGGIVNEPCVFDVEMNGESKDLSFAVEGPSKAEIG 593

  Fly   773 CHDNGDGSALVKYHPTAVGEYAVHILCDNEDIPKSPFIAQIL-PRTDFHPELVKASGPGLEKNGV 836
            |.:..||||::.|.||..|.|.|.:|.|.:.|..|||:.::. |.....|...:.:  |::::.|
 Worm   594 CQERPDGSAILSYTPTVAGVYKVGVLADGKHIQDSPFVLRVTEPIEGLKPSATRVT--GIDESKV 656

  Fly   837 -TINQPTSFTVDPSKAGNAPLDVVVQDVFGTKLPVELKNNPDGTKKVT-----YT--PTSGVPHT 893
             .:.:...|.||....|   :|:|.:...   |..||.....|.:::|     ||  |.:.:.|.
 Worm   657 YNVGEKIPFRVDTRLCG---VDLVPKVEI---LDPELNPISYGAREITPGLFEYTLIPDAPIKHK 715

  Fly   894 VEVNYGGVSTPNSPHRVYVGVPVDAAKVQAFGPWLQPGVRPNAATHFNVDAREAGDAELKVKIIH 958
            ::|:..|||.|.:|..|.|..|.||:|::.|||.:...|.....|.|.:||.:||...::|.:..
 Worm   716 IDVSVAGVSVPGAPFSVKVKEPTDASKLKIFGPGVDGPVYSKEPTRFTIDATQAGPGAVEVALRD 780

  Fly   959 EETKIEVPCRIIDNEDNTYSVEVIPPSKGAYTTTMTYGGQRV-PLGEKVVVEQTVDVSKIKVDGL 1022
            ::.: .|...::||:|.:::|:......|||...:.:.|:.: |:  ::.|:..||||.|:|:||
 Worm   781 DQGE-NVDLDVLDNQDGSFTVKYTAQRPGAYQLNVVFAGEEISPI--EINVKPNVDVSGIRVEGL 842

  Fly  1023 EPTAPLNSLQQFRIITHGLPKADLAVTITSPSGNRIKAHIIPTAEGFLVNFTPTQLGEYLLSICF 1087
            |....|                             |.:|:.||     :|.              
 Worm   843 ENENLL-----------------------------IGSHLRPT-----INI-------------- 859

  Fly  1088 GGTPITPRPFRLQCLTGSDSNKVQAFGPGLERGIVGQPAEFMIDTRGAGQGGLGVTVEGPCEAAI 1152
                                .|::....||:          :||                     
 Worm   860 --------------------GKLEPKSKGLQ----------LID--------------------- 873

  Fly  1153 NCRDNGDGTCNVAYLPTEAGDYTVNITFNERHITGSPFQPLIVPVPNLKNTRVSGIGIQPHGVIM 1217
                                           .:.|..:.   ||:.           |.|.|.. 
 Worm   874 -------------------------------EVNGKRYN---VPMK-----------INPDGTY- 892

  Fly  1218 NAATDFMVDMSKVGSNIDSGKLSCAIFDPMGHVLPSKIVQGPTDDIFRIMYTP-FEAGRHTIELM 1281
              :||                                              || .|.|.|.::|:
 Worm   893 --STD----------------------------------------------TPLMEVGEHKLQLL 909

  Fly  1282 YDNIPVPGSPFVVNVKSGCDPARCKAYGPGLEKGLTNQKNKFTVETKGAGNGGLSLAIEGPSEAK 1346
            :|.|||..:  ||.|..|.|..:|||||||||:.:..:|..|.::..|||.|.||:.:.||::|:
 Worm   910 FDEIPVKEA--VVEVIKGTDVNKCKAYGPGLEQAVVGEKAVFELDLDGAGEGALSMEMRGPAKAE 972

  Fly  1347 MTCTDNRDGSCDVDYLATDPGEYDITIRFA----DKHIPGSPFRVLVEETVDPSKVKVYGPGIEH 1407
            ....|..:|.|.|:|:|..||:|::.|:|.    .:|:.||||:.:|:...|||::.:  .|::.
 Worm   973 SRIQDRGNGKCSVEYVAKAPGDYEMAIKFGKDEQKEHVKGSPFKAVVDYKKDPSQITI--SGLDQ 1035

  Fly  1408 GQVRESVPTFFNVDVGEAGPGRIAVKLTNSEGIPVDNLRVE------DKGNCIYAVHYVPP-KAG 1465
            ...|.:.|..|.:|..:...  :.||.|    :|.|..:::      ......:.|.:||. |..
 Worm  1036 PNYRLNQPINFVIDTSKTKD--LPVKAT----VPSDFAQLQPVVSRSPSNPRHHNVRFVPSGKPN 1094

  Fly  1466 SVLTCQVKFSEVEVPCSPFVMTVFPKSEPTKVKVKGVNEKKK-----TPASLPAEFE----IDTK 1521
            ..:..::.:..:::  ...::.|.|:.||..:|:  :::|||     ||.:..|..|    .|.:
 Worm  1095 VSIPIEIIYDGLKI--DEKLVKVLPEVEPQLIKI--LHDKKKDSLTTTPITTNASHEGHVPFDVR 1155

  Fly  1522 QAGQA-DINVAIKNPKGKAMQPRLEEV----STGTYVVSFVPDECGTYQCSIKYGDKEIEGSPFK 1581
            ..|.. .|...:..|.||   .||..|    ..|.|.|||..|..|.| |.:.|.:.:...:...
 Worm  1156 DCGNVKKIESRVFGPDGK---ERLNHVRSTEQNGIYDVSFPTDMAGEY-CVVFYINGQEVAARVP 1216

  Fly  1582 LEAFPTGEAKKC---------KLVEQAPKIQT-------SGSQSHLKVDAREAGDGAVTCK---- 1626
            :.|...|..:..         ::.|.:|.:.|       ...::|..:....|...||..:    
 Worm  1217 VMAEKIGRKEDVIKEEIVFHPEIAEHSPTVLTYNHPIDAKKKKAHPAIQVLAAKPDAVRLEHIQE 1281

  Fly  1627 -ITNKAGSEIVDIDVIEKDGFFDILYALNDPGDYDINVKFGGKDIPNGSFSIKAVESIEQYSHSE 1690
             :.|  |..:.|          .|::.....|...::|.:||:.:.:..:  :|:..:|.    |
 Worm  1282 LVDN--GHRVAD----------RIVFTATKLGTNTLDVFYGGEHVDHVEY--EAIGKLEY----E 1328

  Fly  1691 YIEEHTTKVVQQ----------------------------------TTQSELVNGKSEITYRSVA 1721
            .|:....|||.:                                  |.|....||..:....|..
 Worm  1329 RIQAERAKVVVEKEDDVDKYEKQYKDEPSSAPADPRVAPTNGKEPTTAQESKKNGNQQKLAPSAE 1393

  Fly  1722 FEKLPLP---TTGGNV----------TAEVRMPSGKVDKPVIQDNRDGTVSVKYDPREEGSHELV 1773
            .|..||.   |...||          .|.|..|:.|.:...|.||.|||:.|||.|:..|||||.
 Worm  1394 IEHKPLEKYFTFQFNVRDLGYQPKDLEAIVMPPTQKKEVAEIIDNLDGTILVKYTPKVHGSHELS 1458

  Fly  1774 VKYNGEPVQGSPFKFHVDSITSGYVTAYGPGLTHGVTGEPANFTISTKGASAGGLTMAVEGPSKA 1838
            :..||..:||:|.||:||:...|:.|.|||||.:.|.||||.||:..||:.|..|::::|||:|:
 Worm  1459 ILQNGAQLQGTPIKFYVDAYGDGWATVYGPGLQNAVVGEPATFTVCAKGSQAKELSVSIEGPAKS 1523

  Fly  1839 DINYHDNKDGTVSVQYLPTAPGEYQVSVRFGDKHIKGSPYFAKITGEGRKRNQISVGSCSEVTMP 1903
            .|..|||||||.|..::|..||||:|.|:.|.|.:|.||:...:.|||:||:.:||||.|||.:|
 Worm  1524 QIKIHDNKDGTCSAAWVPPVPGEYKVHVKLGGKAVKDSPFRVLVMGEGQKRSHLSVGSTSEVALP 1588

  Fly  1904 GDITDDDLRALNASIQAPSGLEEPCFLKRMPTGNIGISFTPREIGEHLVSVKRLGKHINNSPFKV 1968
              ||..:|:.::|||::|.|:|||||::.:..|.:|:||||||.||||::|||.||.:..:|||:
 Worm  1589 --ITQQELKGISASIKSPGGIEEPCFVRLLDGGRLGVSFTPREAGEHLITVKRDGKLVPKAPFKI 1651

  Fly  1969 TVCEREVGDAKKVKVSGTGLKEGQTHADNIFSVDTRNAGFGGLSVSIEGPSKAEIQCTDKDDGTL 2033
            .|.:.:||||.||:|||:|..:|.|...|...|||..||:||||||::||||||:.|.:...|.:
 Worm  1652 KVDKTQVGDASKVEVSGSGKAKGITLQANELLVDTSKAGYGGLSVSVQGPSKAELTCKEVKSGLI 1716

  Fly  2034 NISYKPTEPGYYIVNLKFADHHVEGSPFTVKVAGEGSNRKREKIQRERDAVPITEIGSQCKLTFK 2098
            .:.|.|||||.|.:.:|||||||:.||.||:..|:.:.|..:.||::.:...|.....:..|..|
 Worm  1717 KVLYTPTEPGVYAIAIKFADHHVKDSPLTVQCTGKSAGRVIQTIQKDVEQHGICLPDQESHLFLK 1781

  Fly  2099 MPGITSFDLAACVTSPSNVTEDAEIQEVEDGLYAVHFVPKELGVHTVSVRYSEMHIPGSPFQFTV 2163
            :...:..|:.|.:..|...|:|.|::::....|.:.|.||..|:||:||.|.:.|:.||||||||
 Worm  1782 LLNTSPMDITARLMDPKGHTDDIEMRDLGQQYYQLKFTPKMEGIHTLSVMYKDAHVNGSPFQFTV 1846

  Fly  2164 GPLRDSGSHLVKAGGSGLERGVVGEAAEFNVWTREAGGGSLAISVEGPSKADIEFKDRKDGSCDV 2228
            |...:.|:|.|:|.|.|:.||..|....||::.||||.|::|:::||||||.:||||..||:|.|
 Worm  1847 GSFSEGGAHKVRAAGQGVVRGETGTFNAFNIYHREAGVGAVAVTIEGPSKATLEFKDHNDGNCHV 1911

  Fly  2229 SYKVTEPGEYRVGLKFNDRHIPDSPFKVYVSPDAGDAHKLEVQQFPQGNIQADAPYQFMVRKNGA 2293
            .|||..||||.|.:||||:||||||||||::|..|:..|||:.||....|.|...:.|.|..:.|
 Worm  1912 DYKVATPGEYVVAVKFNDQHIPDSPFKVYIAPATGEVRKLELAQFHGQGIPAGKAFTFTVLTHRA 1976

  Fly  2294 KGELDAKIVAPSGTDDDC-FIQVIDGEMYSVRFYPRENGIHAIHVKFNGVHIPDSPFRIKV-GKD 2356
            ||.|:||:|.|:...|.. .:.:.|||.|::||.|:|.|.|.|||..:|..:.:||||::| |||
 Worm  1977 KGHLEAKVVTPNNEVDTIDIVPIEDGESYAMRFVPKETGNHFIHVTLDGAPMRESPFRLRVGGKD 2041

  Fly  2357 VADPAAVHASGNGLDEVKTGHKADFIINTCNAGVGTLAVSIDGPSKVAMDCTEVEEGYKVRYTPL 2421
            :.||.|:.|||:||.:..||.|.:|:|||.|||.|.|.|.:|||||..:|..|:|:|||||||||
 Worm  2042 LCDPTAISASGDGLVKGTTGQKCEFVINTANAGAGILTVQMDGPSKATLDAYELEKGYKVRYTPL 2106

  Fly  2422 LPGEHYITVKYNNMHIVGSPFKVNATGDKLADEGAQETSTVIVETVQKVAKGGKNTGVHLPTFKS 2486
            .||.::.:||||.:|..|||||:...|.:|...|..|||.|.::.|.|.:||   |...:|.::.
 Worm  2107 APGSYFASVKYNGIHAPGSPFKIPVEGKELGGNGYNETSHVKIDAVAKTSKG---TVAVVPEYQG 2168

  Fly  2487 DASKVVSKGMGLKKAYIGKQNQFSISATDAGNNILYVGMYGPKGPCEEFHVKHAGHNNYNVQYLV 2551
            ||:||.:||.||.|.:.|:...|.|....||.|:|.||:...||||||..|:|.|..:|...|.:
 Worm  2169 DAAKVTAKGAGLNKFFPGRPAAFQIDTGLAGTNLLMVGVVTTKGPCEEVVVRHQGSGHYVCSYRI 2233

  Fly  2552 RDRGQYVLLIKWGEEHIPGSPFQID 2576
            .||.:..:.||:|::.||||||.|:
 Worm  2234 PDRVKGFVFIKYGDKEIPGSPFAIE 2258

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cherNP_001262659.2 CH_dFLNA-like_rpt1 175..297 CDD:409160 78/122 (64%)
CH_dFLNA-like_rpt2 298..415 CDD:409164 57/118 (48%)
IG_FLMN 432..527 CDD:214720 26/104 (25%)
IG_FLMN 532..627 CDD:214720 27/96 (28%)
IG_FLMN 631..724 CDD:214720 20/106 (19%)
IG_FLMN 728..815 CDD:214720 40/87 (46%)
IG_FLMN 821..913 CDD:214720 25/99 (25%)
IG_FLMN 918..1001 CDD:214720 22/83 (27%)
Filamin 1012..1098 CDD:395505 15/85 (18%)
IG_FLMN 1109..1196 CDD:214720 6/86 (7%)
Filamin 1197..1293 CDD:395505 15/96 (16%)
IG_FLMN 1302..1392 CDD:214720 37/93 (40%)
IG_FLMN 1395..1490 CDD:214720 17/101 (17%)
IG_FLMN 1494..1587 CDD:214720 29/106 (27%)
IG_FLMN 1606..1682 CDD:214720 13/80 (16%)
IG_FLMN <1731..1791 CDD:214720 28/69 (41%)
IG_FLMN 1797..1884 CDD:214720 42/86 (49%)
IG_FLMN 1978..2067 CDD:214720 47/88 (53%)
Filamin <2111..2159 CDD:395505 17/47 (36%)
IG_FLMN 2172..2260 CDD:214720 52/87 (60%)
IG_FLMN 2265..2354 CDD:214720 37/90 (41%)
IG_FLMN 2360..2448 CDD:214720 49/87 (56%)
IG_FLMN 2488..2577 CDD:214720 40/89 (45%)
fln-1NP_001294364.1 SAC6 23..>277 CDD:227401 140/268 (52%)
Filamin 261..358 CDD:391771 25/102 (25%)
Filamin 367..446 CDD:391771 27/94 (29%)
IG_FLMN 549..637 CDD:214720 40/87 (46%)
Filamin 643..737 CDD:391771 26/101 (26%)
IG_FLMN 740..830 CDD:214720 24/92 (26%)
IG_FLMN 930..1020 CDD:214720 36/89 (40%)
dapB <1093..1209 CDD:129147 31/123 (25%)
IG_FLMN <1406..1476 CDD:214720 28/69 (41%)
IG_FLMN 1484..1567 CDD:214720 42/82 (51%)
IG_FLMN 1661..1750 CDD:214720 47/88 (53%)
Filamin <1790..1841 CDD:366210 17/50 (34%)
IG_FLMN 1854..1944 CDD:214720 52/89 (58%)
IG_FLMN 1959..2039 CDD:214720 32/79 (41%)
IG_FLMN 2045..2133 CDD:214720 49/87 (56%)
IG_FLMN 2170..2258 CDD:214720 39/87 (45%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 137 1.000 Domainoid score I3035
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H1119
Inparanoid 1 1.050 1347 1.000 Inparanoid score I65
Isobase 1 0.950 - 0 Normalized mean entropy S4348
OMA 1 1.010 - - QHG48636
OrthoDB 1 1.010 - - D24684at33208
OrthoFinder 1 1.000 - - FOG0001288
OrthoInspector 1 1.000 - - oto20067
orthoMCL 1 0.900 - - OOG6_100805
Panther 1 1.100 - - LDO PTHR38537
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3976
SonicParanoid 1 1.000 - - X791
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
1413.960

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