DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment cher and Macf1

DIOPT Version :10

Sequence 1:NP_001262659.2 Gene:cher / 42066 FlyBaseID:FBgn0014141 Length:2577 Species:Drosophila melanogaster
Sequence 2:XP_036019483.1 Gene:Macf1 / 11426 MGIID:108559 Length:7616 Species:Mus musculus


Alignment Length:2765 Identity:491/2765 - (17%)
Similarity:841/2765 - (30%) Gaps:1017/2765 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly   206 DRSINNLETDL--------SDGLRLIALIEVLSQKRMPKYNKRPTFRSQKLENVSVALKFLQDEG 262
            |.|::.:...:        ||||||..:                  |.:..|....:..|.:::|
Mouse   281 DLSVSGITVSILPSSSGYGSDGLRLHGI------------------RPEDTEPEKTSTPFSEEDG 327

  Fly   263 IKIVNIDSSDIVDCKLKLILGLIWTLILHYSISMPMWDGEDDKQLNGSGH-TPKQRLLNW---IH 323
              .::::.|||.                   ||     ||       ||. :.|::||.|   :.
Mouse   328 --TLSLEISDIY-------------------IS-----GE-------SGDMSAKEKLLLWTQKVT 359

  Fly   324 AKIPDLPINNFTNDWTTGKAVGALVDACAPGLCPDWELWDPKDAVQNASEAMGLADDWLNVRQLI 388
            |....:...||::.|:.||...||:....|.|. |.|....:...:|..:|..:|:. |.|.:|:
Mouse   360 AGYTGVKCTNFSSCWSDGKMFNALIHRYRPDLV-DMERVQVQSNRENLEQAFEVAER-LGVTRLL 422

  Fly   389 KPEELVNPNVDEQSMMTYLSQYPNSKLKTGAPLRPKTNPNSIPPPRVRAYGPGIEPIGPVVGAPA 453
            ..|::..|:.||:|::||:|...::.                  |:|...|.||           
Mouse   423 DAEDVDVPSPDEKSVITYVSSIYDAF------------------PKVPEGGEGI----------- 458

  Fly   454 NFTVETFSAGKGSVDVDIQGPNGEIEKADVRFNNDKNLTYTVSYIPKSEGSHKVAVKFSGRDIPK 518
                       .:.:||.:....: .:.|             |.||... .|.:.:  |.:..|:
Mouse   459 -----------SATEVDSRWQEYQ-SRVD-------------SLIPWIR-QHTILM--SDKSFPQ 495

  Fly   519 SPFPVKV----------------EGHAG-------------DASKVKVTGPGIQPNGVTIKKPTF 554
            :|..:|.                |...|             :..::|:. .|..||.|       
Mouse   496 NPVELKALYNQYIHFKETEILAKEREKGRIKELYKLLEVWIEFGRIKLP-QGYHPNHV------- 552

  Fly   555 FDILAKDAGRGVPEVI----IIDPANHKTSVAAKV-RQLENDTWRCEYVTALQGLHSVNVFYAGT 614
                .::.|:.:.|::    .:.||..:..:..:: .:::|....||....|    :.|...|  
Mouse   553 ----EEEWGKLIVEMLEREKSLRPAVERLELLLQIANKIQNGALNCEEKLTL----AKNTLQA-- 607

  Fly   615 PIPNSPFPVKVAPLSDARKVRASGRGLQATGVRVGDDADFKIYTEGAGEGEPEVRVIGPGGMNQN 679
                           ||..:. ||:.:|.       ::|..:|.:   |.|..:|          
Mouse   608 ---------------DAAHLE-SGQPVQC-------ESDVIMYIQ---ECEGLIR---------- 636

  Fly   680 VMQSKVDGNTY-ECHYYPTKEGRYVIM------VT-------------FAGQEVAK----SPFEV 720
              |.:||.... :..||..:|..:.:|      ||             |:..|:..    :...:
Mouse   637 --QLQVDLQILRDEKYYQLEELAFRVMRLQDELVTLRLECTNLYRKGHFSSLELVPPSTLTTTHL 699

  Fly   721 KVGPKKE---SSIVAY--GPGLSSGVIGYPAAFVVETNGETGALGFTV-----AGPSQAEIECHD 775
            |..|..:   ||..::  .|...:.::.      :.::.:.|.|.|..     ....|.::|..:
Mouse   700 KAEPLNKTTHSSSTSWFRKPMTRTELVS------ISSSEDEGNLRFVYELLSWVEEMQMKLERAE 758

  Fly   776 NGDGSALVKYHPTAVGEYAVHILCDNEDIPKSPFIAQILP---RTDFHPELVKASGPGLEKNGVT 837
            .|:....|:...    |...||....|::..|...|::..   ..:||...|:..|. ||.....
Mouse   759 WGNDLPSVELQL----ETQQHIHTSVEELGSSVKEARLYEGKMSQNFHTSYVETLGK-LETQYCK 818

  Fly   838 INQPTSFTVDPSKAGNAPLDVVVQDVFGTKLPVEL----------------KNNPDGTKKVTYTP 886
            :.:.:||.:...::.:.         |.::...||                .:||:.:.|.||..
Mouse   819 LKETSSFRMRHLQSLHK---------FVSRATAELIWLNGKEEEELACDWSDSNPNISAKKTYFS 874

  Fly   887 T------------SGVPHTVEVNYGGVSTPNSPHRVYVGVPVDAAKVQAFGPWL-------QPGV 932
            .            ..:..|.||    :|..|.|.:  ..|...:|.||:...|:       :..|
Mouse   875 ELTMELEGKQDVFRSLQDTAEV----LSLENHPAK--QTVEAYSAAVQSQLQWMKQLCLCVEQHV 933

  Fly   933 RPNAA-THFNVDAREAGDAELKVKIIHEETKIEVPCRIIDNEDNTYSVEVIPPSKGAYTTTMTYG 996
            :.||| ..|..|||   |.|..::.:.:..|.:..|      |.:.|:..:   :.....:|...
Mouse   934 KENAAYFQFFSDAR---DLESFLRNLQDSIKRKYTC------DRSTSLSRL---EDLLQDSMAQD 986

  Fly   997 GQRVPLGEKVVVEQTVDVSKIKVDGLEPTAP---------LNSLQQFRIITHGLPKADLAV---- 1048
            .:...:..|..|...|..||..|. |:|..|         :.::..:|.|...:.|.|..|    
Mouse   987 EKEQLIQSKSSVASLVGRSKTIVQ-LKPRNPDHVLKSTLSVKAICDYRQIEITICKNDECVLEDN 1050

  Fly  1049 ------TITSPSGNRIKAHIIPTAEGFLVNFTPTQLGEYLLSICFGGTPITPRPFRLQCLTGSDS 1107
                  .:.||:||..   ::|                   |:||...|.......:........
Mouse  1051 SQRTKWKVISPTGNEA---MVP-------------------SVCFLIPPPNKEAIEMASRVEQSY 1093

  Fly  1108 NKVQAFGPGLERGIVGQPAEFMIDTRGAGQGGLGVTVEGPCEAAINCRDNGDGTCNVAYLPTEAG 1172
            .||.|....|.           |:|:.                                      
Mouse  1094 QKVMALWHQLH-----------INTKS-------------------------------------- 1109

  Fly  1173 DYTVNITFNERHITGSPFQPLIVPVPNLKNTRVSGIGIQPHGVIMNAAT---DFMVDMSKVGSNI 1234
              .::..:..:.:.       .|...:|:..|....| :.|.|:.|...   ||:.|      :.
Mouse  1110 --LISWNYLRKDLD-------TVQTWSLEKLRSLAPG-ECHQVMKNLQAHYEDFLQD------SH 1158

  Fly  1235 DSGKLSCAIFDPMGHVLPSKIVQGPTDDIFRIMYTPFEAGRHTIELMYDNIPVPGSPFVVNVKSG 1299
            ||...|.|                   |..||        ...:|                    
Mouse  1159 DSALFSVA-------------------DRLRI--------EEEVE-------------------- 1176

  Fly  1300 CDPARCKAYGPGLEKGLTNQKNKFTV------ETKGAGNGGLSL---------AIEGPSEAKMTC 1349
                .|||:...|.|.|.|:..:.|:      |.|   |..|.|         .|:.|:.:|   
Mouse  1177 ----ACKAHFQHLMKSLENEDKEETLAKVYISELK---NIRLLLEECEQRLLKQIQSPASSK--- 1231

  Fly  1350 TDNRDGSCDVDYLATDPGEYDITIRFAD--------KHIPG------------------------ 1382
            || ||            ...|||:|.|:        :|:..                        
Mouse  1232 TD-RD------------ARQDITLRIAEQEHTQEDLQHLRSDLDAISMKCNVFLQQSPSGSSATT 1283

  Fly  1383 --SPFRVLVEE--------TVDPSKVKVYGPGIEHGQVRESVPTFFNVDVGEAGPGRIAVKLTNS 1437
              |...::||:        ||..:|:|.....:...|..|.:...:.            :||:..
Mouse  1284 LRSELNLMVEKMDHVYGLSTVYLNKLKTIDVIVRSMQDAELLVKGYE------------IKLSQE 1336

  Fly  1438 EGIPVDNLRVEDKGNCIYAVHYVPPKAGSVLTCQVKFSEVEVPCSPFVMTVFPKSEPTKVKVKGV 1502
            |.:|.|...:|....                |.|...|:|:...|     ||...:....|.|.|
Mouse  1337 EAVPADLSALESHRT----------------TLQHWLSDVKDKNS-----VFSVLDEEITKAKKV 1380

  Fly  1503 NEKKKTPASLPAEFEIDTKQAGQADINVAIKNPKGKAMQPR----LEEVSTGTYVVSFVPDECGT 1563
            .|:.:.|||.|             ::::.....||..:|.|    :.::.|....|..:.:....
Mouse  1381 AEQLRHPASEP-------------NLDLERYQEKGSQLQERWHRVIAQLETRQSEVESIQEVLRD 1432

  Fly  1564 YQCSIKYGDKEIEGSPFKLEAFPTGEAKKCKLVEQAPKIQT----SGSQSHLKVDAREAGDGAVT 1624
            |:.......|.||.:..:.|....|:|:..:::.:....||    ...::..|:|         .
Mouse  1433 YRACHGTLIKWIEETTAQQEMMKPGQAEDSRVLSEQLSQQTELFAEIERNQTKLD---------Q 1488

  Fly  1625 CKITNKAGSEIVDIDVIEKDGFFDILYALNDPGDYDINVKFGGKDIPNGSFSIKAVESIEQ---- 1685
            |:..::..|.||      ||....::       .|...|:...|........|.:.::|.|    
Mouse  1489 CQKFSQQYSTIV------KDYELQLM-------TYKAFVESQQKSPGKRRRMISSSDAITQEFMD 1540

  Fly  1686 ----YS--------HSEYIE------EHTTKVVQQTTQSELVNGKSEITYRSVAFEKLPLPTTGG 1732
                |:        |.:||.      |...|||::..|..:...|..:.:.|....     .|.|
Mouse  1541 LRTRYTALVTLTTQHVKYISDALRRLEEEEKVVEEEKQEHVEKVKDLLGWVSTLAR-----NTQG 1600

  Fly  1733 NVTAEVRMPSGKVDKPVIQDNRDGTVSVKYDPREEGSHELVVKYN--GEPVQGSPFKFHVDSITS 1795
            ..|:.....|..::|.:::             ::..:.||..|..  .|.::.|..         
Mouse  1601 TTTSSHTSASADIEKAILE-------------QQVLAEELTTKKEQVSEAIKTSQI--------- 1643

  Fly  1796 GYVTAYGPGLTHGVTGEPANFTISTKGASAGGLTMAVEGPSKADIN---------YHDNKDGTVS 1851
             ::..:|..|:.|                           .|..|:         |||..||:.:
Mouse  1644 -FLAKHGHKLSEG---------------------------EKEQISEQLRVLNKTYHDLCDGSAN 1680

  Fly  1852 -VQYLPTAPGEYQVSVRFGDKHIKGSPYFAKITGEGRKRNQISVGSCSEVTMPGDITDDDLRALN 1915
             :|.|.:...:        ....||....|.:...|    .:.:.........|.|..|....|.
Mouse  1681 QLQQLQSELAQ--------QTEQKGCRAVAGVIDLG----TVEIFPIFRAMQKGLIDQDTGLVLL 1733

  Fly  1916 ASIQAPSGLEEPCFLKRMPTGNIGISFTPREIGEHLVSVKRLGKHINNSPFKVTVCEREVGDAKK 1980
            .|....|||.:|                  |..|.|...:.|.::..|.|....:          
Mouse  1734 ESQIIMSGLIDP------------------ENSEKLSLEEGLTRNFINLPIYQQL---------- 1770

  Fly  1981 VKVSGTGLKEGQTHADNIFSVDTRNAGFGGLSV--SIEGPSKAE---IQCTDKDDGTLNISYKPT 2040
                 .||:      |::..|.......|.|||  :||....:|   ::..:....|...|..|:
Mouse  1771 -----LGLR------DSLSLVSRLTGTLGSLSVVEAIEKKIISERLGLKVLEVHLATGGFSLPPS 1824

  Fly  2041 EPGYYIVNLKFADH--------------HVEGS-----PFTVKVAGEGSNRKREKIQRER--DAV 2084
            |   ..:||:.|.|              |:..|     |.|.:..|.....:|..|.:|.  ..:
Mouse  1825 E---NCINLEEAFHQGFIASSLHSELQSHLRSSKNLIDPNTAEKVGLLDLMQRCIIHQESGLKLL 1886

  Fly  2085 PITEIGSQCKLTFKMPGITSFDLAACVTSPSNVTE-----DAEIQEVEDGLYAVHFVPKELGVHT 2144
            |:.::..         |:.|......|:....|.|     ...::.:|..|:|...|....| |.
Mouse  1887 PVKQLAG---------GMVSLKSGRKVSIFRAVQEGLIDRQVTVRLLEAQLFAGGIVDPRTG-HR 1941

  Fly  2145 VSVRYSEMH------------------------------------------------IPGSPFQF 2161
            ::|..:..|                                                |..|.:.|
Mouse  1942 LTVEEAVRHNLIDQDMACAILIRQLQTGGIIDTVTGDRMTIDEAVTNNLVAAKIALVILESLWSF 2006

  Fly  2162 TVGPLRDSGSHLVKAGGSGLERGVVG-EAAEFNVWTREAGGGSLAISVEG---PSKADIEFKDRK 2222
            ....|.:||..|...  ..||:|:|. |.|...:..|:        .:|.   |:..:|...:  
Mouse  2007 MGLLLPESGEILPIT--DALEQGIVSTELAHKILHNRQ--------QIEALFLPTLTEIWSWE-- 2059

  Fly  2223 DGSCDVSYKVTEPGEYRVGLKFNDRH--IPDSPFKVYVSPDA--------------------GDA 2265
                    |.||.|.....|..|.|.  |||....:.::..|                    |.:
Mouse  2060 --------KATESGILDKDLVNNLRSVCIPDMMPHIQLADSAEQSKVGFAAGKPPVSGPREEGSS 2116

  Fly  2266 H--KLEVQQFPQGNIQADAPYQFMVRKNGAKGELDAKIVAPSGTDDDCFIQVIDGEMYSVRFYPR 2328
            |  ||..|......|.|....:.::        ||.::|....:.|||  |||..|::.:: :.|
Mouse  2117 HGEKLLFQLMTHSYIHAHTGQRLLL--------LDQELVEMLTSRDDC--QVILPEVFEIQ-HQR 2170

  Fly  2329 ENGIHAIHVKFNGVHIPDSPFRIKVGKDVADPAAVHASGNGLDEVKTGHKADFIINTCNAGVGTL 2393
            .|...|:...:.|     :..:|...|....|..........|....        ..|....|..
Mouse  2171 LNTSEALQELYTG-----TISQISSAKHPRKPCESQFLSQNKDYPSQ--------ENCTEAKGER 2222

  Fly  2394 AVSIDGPSKVAMDCTEVEEGYKVRY-------------------------TPLLPG---EHYITV 2430
            :|       |.::|:..|...:..:                         .|||..   |...|:
Mouse  2223 SV-------VGIECSPAESPERELFLKEQEAIIENVGSLKVINKVKLKLQRPLLGSRKEEQAETL 2280

  Fly  2431 KYNNMHIVGSPFKV----NATGDKLADEGAQ-ETSTVI--------VETVQKVAKGGKNTGVHLP 2482
            :..|  |.|.|..|    .:.|..|:.|.:: :|.|..        |:|::.:.   ..||..|.
Mouse  2281 REEN--ISGDPLLVECPEESEGKDLSTEKSKCQTPTKCSFTCHKEQVKTIKDIP---SETGTSLI 2340

  Fly  2483 TFKSDASKV-VSKGMGLKKAYIGKQNQFSISATDAGNNILYVGMYGPKGPCEEFHVKHAGHNNYN 2546
            ..::..|:. |...:||:..: ..::..::::.:             |...||..||. ||....
Mouse  2341 KSQNQMSQFQVDTSVGLRSEF-KSEHDMNVNSLE-------------KELKEELLVKD-GHKQSQ 2390

  Fly  2547 VQYLVRDRGQYVLLIKWGEEH-------IPGSPFQ 2574
            ....|.| ||.|.|.|...|.       :..|||:
Mouse  2391 EGQSVAD-GQTVALEKTDTEDNADEPALLHSSPFE 2424

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cherNP_001262659.2 CH_dFLNA-like_rpt1 175..297 CDD:409160 17/98 (17%)
CH_dFLNA-like_rpt2 298..415 CDD:409164 34/120 (28%)
IG_FLMN 432..527 CDD:214720 16/110 (15%)
IG_FLMN 532..627 CDD:214720 15/99 (15%)
IG_FLMN 631..724 CDD:214720 21/116 (18%)
IG_FLMN 728..815 CDD:214720 16/93 (17%)
IG_FLMN 821..913 CDD:214720 20/119 (17%)
IG_FLMN 918..1001 CDD:214720 19/90 (21%)
Filamin 1012..1098 CDD:395505 21/104 (20%)
IG_FLMN 1109..1196 CDD:214720 6/86 (7%)
Filamin 1197..1293 CDD:395505 17/98 (17%)
IG_FLMN 1302..1392 CDD:214720 29/146 (20%)
IG_FLMN 1395..1490 CDD:214720 16/94 (17%)
IG_FLMN 1494..1587 CDD:214720 19/96 (20%)
IG_FLMN 1606..1682 CDD:214720 12/75 (16%)
IG_FLMN <1731..1791 CDD:214720 9/61 (15%)
IG_FLMN 1797..1884 CDD:214720 15/96 (16%)
IG_FLMN 1978..2067 CDD:214720 23/112 (21%)
Filamin <2111..2159 CDD:395505 13/100 (13%)
IG_FLMN 2172..2260 CDD:214720 21/93 (23%)
IG_FLMN 2265..2354 CDD:214720 21/90 (23%)
IG_FLMN 2360..2448 CDD:214720 18/119 (15%)
IG_FLMN 2488..2577 CDD:214720 22/95 (23%)
Macf1XP_036019483.1 CH_MACF1_rpt2 343..449 CDD:409089 31/125 (25%)
SPEC 737..935 CDD:238103 40/217 (18%)
SH3_10 1010..1076 CDD:407754 16/88 (18%)
Spectrin_like 1111..1188 CDD:465730 22/141 (16%)
SPEC 1317..1496 CDD:413338 41/233 (18%)
Plectin 1732..1770 CDD:459901 12/55 (22%)
Plectin 1809..1847 CDD:459901 8/40 (20%)
Plectin 1923..1958 CDD:459901 8/35 (23%)
Plectin 1961..1999 CDD:459901 0/37 (0%)
Plectin <2008..2037 CDD:459901 10/30 (33%)
Plectin 2431..2468 CDD:459901
Plectin 2512..2544 CDD:459901
Plectin 2544..2582 CDD:459901
Plectin 2640..2678 CDD:459901
Plectin 2826..2864 CDD:459901
Plectin 2868..2899 CDD:459901
SMC_prok_B <3496..3868 CDD:274008
SMC_prok_B 3745..4500 CDD:274008
SPEC 3996..4224 CDD:238103
SPEC 4581..4800 CDD:238103
SPEC 4806..5020 CDD:238103
SMC_prok_B 4995..5925 CDD:274008
SPEC 5461..5674 CDD:238103
SPEC 5896..6109 CDD:238103
SPEC 6006..6225 CDD:238103
SPEC 6227..6444 CDD:238103
SPEC 6447..6663 CDD:238103
SPEC 6668..6882 CDD:238103
SPEC 6887..7099 CDD:238103
SPEC 7109..7233 CDD:197544
FRQ1 <7267..7337 CDD:444056
GAS2 7342..7420 CDD:128539
PHA03307 <7441..>7614 CDD:223039
Blue background indicates that the domain is not in the aligned region.

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