DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment cher and flnb

DIOPT Version :9

Sequence 1:NP_001262659.2 Gene:cher / 42066 FlyBaseID:FBgn0014141 Length:2577 Species:Drosophila melanogaster
Sequence 2:XP_017213862.2 Gene:flnb / 100534866 -ID:- Length:2592 Species:Danio rerio


Alignment Length:2635 Identity:1181/2635 - (44%)
Similarity:1582/2635 - (60%) Gaps:282/2635 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly   177 ERDLAEDAQWKKIQQNTFTRWANEHLKTIDRSINNLETDLSDGLRLIALIEVLSQKRM-PKYNKR 240
            |:|||:||.||||||||||||.|||||:.::.:.:|:.|||||||||||:||||||:| .||:.|
Zfish     5 EKDLADDAPWKKIQQNTFTRWCNEHLKSANKRVADLQQDLSDGLRLIALLEVLSQKKMFRKYHSR 69

  Fly   241 PTFRSQKLENVSVALKFLQDEGIKIVNIDSSDIVDCKLKLILGLIWTLILHYSISMPMWDGEDDK 305
            ||||..|||||||||:||..|.||:|:|||..|||..|||||||:||||||||||||:|:.|||.
Zfish    70 PTFRQMKLENVSVALEFLDRENIKLVSIDSKAIVDGNLKLILGLVWTLILHYSISMPVWEDEDDD 134

  Fly   306 QLNGSGHTPKQRLLNWIHAKIPDLPINNFTNDWTTGKAVGALVDACAPGLCPDWELWDPKDAVQN 370
            :  ....|||||||.||..|:|||||.||:.||..|:|:|||||:||||||||||:||.:..|.|
Zfish   135 E--AKKQTPKQRLLGWIQNKVPDLPITNFSQDWRNGRALGALVDSCAPGLCPDWEIWDSEKPVDN 197

  Fly   371 ASEAMGLADDWLNVRQLIKPEELVNPNVDEQSMMTYLSQYPNSKLKTGAPLRPKTNPNSIPPPRV 435
            |:|||.||||||.:.|:|.|||:::|:|||||:||||||:|.:|||.||||:||.||.     :.
Zfish   198 ATEAMQLADDWLGIPQVIAPEEIIDPSVDEQSVMTYLSQFPKAKLKPGAPLKPKLNPK-----KA 257

  Fly   436 RAYGPGIEPIGPVVGAPANFTVETFSAGKGSVDVDIQGPNGEIEKADVRFNNDKNLTYTVSYIPK 500
            |||||||||.|..|..||.|||:|||||:|.|.|.::.|.|..|:.....|..|. ||:|:|:|:
Zfish   258 RAYGPGIEPTGNRVMRPAVFTVDTFSAGQGQVMVYVEDPEGRREEVKPVLNEGKK-TYSVTYVPQ 321

  Fly   501 SEGSHKVAVKFSGRDIPKSPFPVKVEGHAGDASKVKVTGPGIQPNGVTIKKPTFFDILAKDAGRG 565
            ..|:|||.|.|:|:.||||||.|.|:...||.:||...|||::|.|....|||||||....||.|
Zfish   322 VMGTHKVTVLFAGQQIPKSPFEVNVDKAQGDPTKVTAKGPGLEPLGNIANKPTFFDIYTAGAGVG 386

  Fly   566 VPEVIIIDPANHKTSVAAKVRQLENDTWRCEYVTALQGLHSVNVFYAGTPIPNSPFPVKVAPLSD 630
            ....:|.||..:|.:|.|.:.....:.:||.|.....|.|:||:.:.|..||.|||.|.:.|.|.
Zfish   387 DVTAVIKDPLGNKNTVEAVMEDKGENVFRCTYKPVQAGPHTVNITFGGIAIPKSPFAVNIGPASV 451

  Fly   631 ARKVRASGRGLQATGVRVGDDADFKIYTEGAGEGEPEVRVIGPGGMNQNVMQSKVDGNTYECHYY 695
            ....||:|||||..||||...||||:.|..||.|:.:|.|.||.|:.:.|.|.......|...||
Zfish   452 PGACRATGRGLQPRGVRVRQVADFKVDTRNAGSGDLKVTVKGPKGLEEPVKQKDASDGVYSYEYY 516

  Fly   696 PTKEGRYVIMVTFAGQEVAKSPFEVKV----GPKKESSIVAYGPGLSSGVIGYPAAFVVETNG-E 755
            |...|:|.:.:|:|||.:.||||||.|    ||:|   |.|:||||..|::|..|.||.|:.| :
Zfish   517 PHATGKYSVSITWAGQHIPKSPFEVHVGSEAGPQK---IRAWGPGLEGGIVGKSADFVAESIGTD 578

  Fly   756 TGALGFTVAGPSQAEIECHDNGDGSALVKYHPTAVGEYAVHILCDNEDIPKSPFIAQILPRTDF- 819
            .|.|||.:.|||||.|||.|..|||..|:|.||..||||||::||:|||..|||:|.|:|.... 
Zfish   579 VGILGFAIEGPSQARIECEDQNDGSCDVRYWPTEAGEYAVHVMCDDEDIEDSPFMAIIVPDNKAN 643

  Fly   820 HPELVKASGPGLEKNGVTINQPTSFTVDPSKAGNAPLDVVVQDVFGTKLPVELKNNPDGTKKVTY 884
            :|.||||.||||||:|..||:|..|||:.:.||..||.:..||..|..:.|::|:..|.....:|
Zfish   644 NPGLVKAYGPGLEKSGCIINKPAEFTVEATDAGAGPLKITAQDAAGVPVEVKVKSRGDQVYSCSY 708

  Fly   885 TPTSGVPHTVEVNYGGVSTPNSPHRVYVGVPVDAAKVQAFGPWLQ-PGVRPNAATHFNVDAREAG 948
            |||:.:.||:.|::.|.|.||||.||.||......||:.|||.:: .|::.:..|||.||..|||
Zfish   709 TPTAAIKHTLAVSWAGASVPNSPFRVNVGKGSHPHKVKVFGPGVEKTGLKAHEPTHFTVDCTEAG 773

  Fly   949 DAE------------------------------------------LKVKIIHEETKIEV-PCR-- 968
            :.:                                          |.:|::..:.:|.| |.|  
Zfish   774 EGDVSVGIKCEANVISGQEEDVDFDIIPNANDTITVKYIPPGAGRLVIKVLFTDQEIPVSPFRVK 838

  Fly   969 -----------------------------------------------------------IIDNED 974
                                                                       ||||.|
Zfish   839 VDPSHDASKVKAEGPGIARAGVESGKPTHFTVYTKGAGKALLDVQFSGPNKAQPVQDFEIIDNYD 903

  Fly   975 NTYSVEVIPPSKGAYTTTMTYGGQRVPLGEK---VVVEQTVDVSKIKVDGLEPTAPLNSLQQFRI 1036
            .:|:|:..|..:|....|::|||.  |:.:.   |.|...:|:|||:|||||....:...|:|.:
Zfish   904 YSYTVKYTPVQQGEMVITVSYGGD--PIAKSPFAVGVAAPLDLSKIQVDGLENRVQVGEDQEFAV 966

  Fly  1037 ITHGL-PKADLAVTITSPSGNRIKAHIIPTAEGFLVNFTPTQLGEYLLSICFGGTPITPRPFRLQ 1100
            .|.|. .:..|.|.:|||||..:...:.|...|.||.:.|.:.|.|::.:.:.|..:...||.::
Zfish   967 GTRGAGGQGKLEVKVTSPSGKSVPCLVEPGKAGSLVKYIPKEEGVYMVELLYDGHLVPGSPFPVE 1031

  Fly  1101 CLTGSDSNKVQAFGPGLERGIVGQPAEFMIDTRGAGQGGLGVTVEGPCEAAINCRDNGDGTCNVA 1165
            .:...|.:||:||||||:.|:|..||||.|||:|||.||||:|||||.||.|.|.|||||||:|:
Zfish  1032 AMLPPDPSKVKAFGPGLKGGLVSSPAEFTIDTKGAGTGGLGLTVEGPTEAKIECSDNGDGTCSVS 1096

  Fly  1166 YLPTEAGDYTVNITFNERHITGSPFQ--------------------------------------- 1191
            |||||.|:|.|||.|...||.||||.                                       
Zfish  1097 YLPTEPGEYLVNILFENVHIPGSPFHADVQYPFDPTKVLASGSGLKRGKVGEVSVLNVDCTTAGP 1161

  Fly  1192 --------------------------------PL------------------------IVPVPNL 1200
                                            ||                        :.|..:.
Zfish  1162 GLLTLDAESDSGVKAKTEVLDNKDGTYTVTYIPLTAGMYTLQLKYGGKSVPSFPAKVKVDPAVDT 1226

  Fly  1201 KNTRVSGIGIQPHGVIMNAATDFMVD---MSKVGSNIDSGKLSCAIFDPMGHVLPSKIVQGPTDD 1262
            ...:|.|.|:...||...|.|.|.||   :||||..    .:...:.:|.| .....|:|..:|.
Zfish  1227 SRVKVFGPGVAGEGVFREATTSFTVDARALSKVGGE----HIKADVKNPSG-ATTDCIIQDNSDG 1286

  Fly  1263 IFRIMYTPFEAGRHTIELMYDNIPVPGSPFVVNVKSGCDPARCKAYGPGLEKGLTNQKNKFTVET 1327
            .:.:.|||||.|.|::|::||..|||.|||.|.|..||||:|.:|.|||||:.||.:.|||::.|
Zfish  1287 TYNVEYTPFENGVHSVEVLYDESPVPKSPFQVGVGEGCDPSRVQARGPGLEEALTEKPNKFSIVT 1351

  Fly  1328 KGAGNGGLSLAIEGPSEAKMTCTDNRDGSCDVDYLATDPGEYDITIRFADKHIPGSPFRVLVEET 1392
            :|||.|||.:.:|||||:||:|.||:||||:|:|....||.||:.|.:..:|||||||:|.|::.
Zfish  1352 RGAGIGGLGITVEGPSESKMSCKDNKDGSCNVEYTPYVPGLYDVNITYGGQHIPGSPFKVPVKDV 1416

  Fly  1393 VDPSKVKVYGPGIEHGQVRESVPTFFNVDVGEAGPGRIAVKLTNSEGI--PVDNLRVEDKGNCIY 1455
            ||.||||:.|.|:..| ||..:|..|.||..:||...::|.:|..:|:  ||:   |.|.|:..:
Zfish  1417 VDSSKVKISGAGVGSG-VRAKIPQSFTVDCSKAGVAPLSVAVTGPKGLAEPVE---VSDNGDGTH 1477

  Fly  1456 AVHYVPPKAGSVLTCQVKFSEVEVPCSPFVMTVFPKSEPTKVKVKGVNEKKKTPASLPAEFEIDT 1520
            .|.|.|...|. .:..||:::.|||.||..:.|.|..:.:||:..|........||.|.||.||.
Zfish  1478 TVSYTPSIEGP-YSVSVKYADEEVPRSPMKLRVLPTHDASKVRASGPGLTTGLSASFPVEFTIDA 1541

  Fly  1521 KQAGQADINVAIKNPKGKAMQPRLEEVSTGTYVVSFVPDECGTYQCSIKYGDKEIEGSPFKLEAF 1585
            |.||:..::|.|.:..||..:..:::...|||.||:|||:.|.|...||||..||..||:::.|.
Zfish  1542 KDAGEGQLSVHITDQDGKLKKANIQDNRDGTYRVSYVPDKVGRYTIVIKYGGDEIPTSPYRVRAT 1606

  Fly  1586 PTGEAKKCKLVEQAPKIQTS---GSQSHLKVDAREAGDGAVTCKITNKAGSEIVDIDVIE-KDGF 1646
            .:|:|.||.:  ..|.|..:   |.:....|:.:.||.|.:.|.:....||| |:.|||: :||.
Zfish  1607 TSGDASKCTV--SGPGIGPTIGIGQEVGFMVNTKGAGKGNLCCVVLTPDGSE-VEADVIQNEDGT 1668

  Fly  1647 FDILYALNDPGDYDINVKFGGKDIPNGSFSIKAVES---IEQYSHSEYIEEHTTKVVQQTTQSEL 1708
            |||.|..:.||.|.|.|:|||::||...|.:.|.:.   ::|.|    :::..:.......|..:
Zfish  1669 FDIFYTAHKPGTYVIYVRFGGENIPKSPFKVMATDEAPMMQQQS----VQQQQSAAPAMGFQPWV 1729

  Fly  1709 VNGKSEITYRSV------AFEK-LPLPTTGGNVTAEVRMPSGKVDKPVIQDNRDGTVSVKYDPRE 1766
            .:| |.:...||      .|:. :|...:.|.:|.||.|||||..:|.|.||:||||:|||.|.|
Zfish  1730 TDG-SYVPANSVNGTGYRPFDMVIPFTFSKGEITGEVHMPSGKSAQPEIIDNKDGTVTVKYSPTE 1793

  Fly  1767 EGSHELVVKYNGEPVQGSPFKFHVDSITSGYVTAYGPGLTHGVTGEPANFTISTKGASAGGLTMA 1831
            .|.||:.:||||..:..||.:|.|::..|..||||||||.:|...:.|.|||.|:.||.|||.:|
Zfish  1794 AGLHEMHIKYNGTHIPESPLQFFVNNANSPNVTAYGPGLVYGTANKTAMFTIYTEDASEGGLDLA 1858

  Fly  1832 VEGPSKADINYHDNKDGTVSVQYLPTAPGEYQVSVRFGDKHIKGSPYFAKITGEGRKRNQISVGS 1896
            :||||||:|:..||||||.:|.||||.||:|.:.||:.||||.|||:.|:||.:.::::|:.:||
Zfish  1859 IEGPSKAEISCVDNKDGTCTVSYLPTLPGDYNILVRYNDKHIAGSPFTARITEDNKRKSQVKLGS 1923

  Fly  1897 CSEVTMPGDITDDDLRALNASIQAPSGLEEPCFLKRMPTGNIGISFTPREIGEHLVSVKRLGKHI 1961
            .::.::  ||.:.||..|.|||:||||.:|||.|||.|..:|||||.|||:||||||:::.|:|:
Zfish  1924 AADFSL--DIMETDLSLLTASIKAPSGRDEPCLLKRQPNNHIGISFIPREVGEHLVSIRKNGRHV 1986

  Fly  1962 NNSPFKVTVCEREVGDAKKVKVSGTGLKEGQTHADNIFSVDTRNAGFGGLSVSIEGPSKAEIQCT 2026
            .|||..:||.:.|:|||.:|||.||||:||||.....|:||||.||:|||::|||||||.:||..
Zfish  1987 PNSPISITVVQSEIGDAGRVKVFGTGLQEGQTFQMADFTVDTREAGYGGLALSIEGPSKVDIQTE 2051

  Fly  2027 DKDDGTLNISYKPTEPGYYIVNLKFADHHVEGSPFTVKVAGEGSNRKREKIQRERDAVPITEIGS 2091
            |.:|||..:||.|||||.|||:::||:.||.||||:|||.|||  |.||.|.|.:.|..::.:||
Zfish  2052 DMEDGTCGVSYCPTEPGTYIVSIRFAEEHVPGSPFSVKVTGEG--RIRESISRRQKAASVSSVGS 2114

  Fly  2092 QCKLTFKMPGITSFDLAACVTSPSNVTEDAEIQEVEDGLYAVHFVPKELGVHTVSVRYSEMHIPG 2156
            .|.|..|:|.:...|:.|.|.|||..||:|::..|.:..|.|.|||:|.|||.|:|||...|:||
Zfish  2115 VCDLNLKIPEVDISDVTAQVISPSGATEEADLVSVGNQTYCVRFVPQETGVHLVNVRYRGQHVPG 2179

  Fly  2157 SPFQFTVGPLRDSGSHLVKAGGSGLERGVVGEAAEFNVWTREAGGGSLAISVEGPSKADIEFKDR 2221
            ||||||||||.:.|:..|:|.|.|||:..|.|.|||.|||||||.|.|:|:|||||:|:|.|::|
Zfish  2180 SPFQFTVGPLGEGGAQKVRAAGPGLEKADVCEPAEFTVWTREAGAGGLSIAVEGPSRAEISFEER 2244

  Fly  2222 KDGSCDVSYKVTEPGEYRVGLKFNDRHIPDSPFKVYVSPDAGDAHKLEVQQFPQGNIQADAPYQF 2286
            |||||.|||...|||:|.|.:||||.|||:|||.|.|.....||.:|.|....:..::.:.|..|
Zfish  2245 KDGSCGVSYVAQEPGDYEVSIKFNDEHIPESPFLVPVFAPVDDARRLTVTSLQESGLKVNQPSSF 2309

  Fly  2287 MVRKNGAKGELDAKIVAPSGTDDDCFIQVIDGEMYSVRFYPRENGIHAIHVKFNGVHIPDSPFRI 2351
            .||.|||||.:.||:.:|||..::|.:..::.:.|::||.|||||||.|.||||..|||.|||:|
Zfish  2310 AVRLNGAKGSISAKVHSPSGALEECAVSELEQDKYAIRFIPRENGIHVIDVKFNDTHIPGSPFQI 2374

  Fly  2352 KVGK--DVADPAAVHASGNGLDEVKTGHKADFIINTCNAGVGTLAVSIDGPSKVAMDCTEVEEGY 2414
            :||:  ...|...|.|.|.||:...||::|:||||...||.|:|:::|:|||||.|:|.|..||:
Zfish  2375 RVGEPGQGGDAGLVTAYGPGLERGTTGNQAEFIINNTKAGPGSLSLTIEGPSKVKMECQECPEGF 2439

  Fly  2415 KVRYTPLLPGEHYITVKYNN-MHIVGSPFKVNATGDKLAD-EGAQETSTVIVETVQKVAKGGKNT 2477
            ||.|||:.||.:.||.||.. .||.|||||...||.:|.: ....|.|.::|::|.:        
Zfish  2440 KVHYTPMAPGNYIITAKYGGPNHITGSPFKAKVTGPRLVNVSSVSEMSCLMVDSVTR-------- 2496

  Fly  2478 GVHLPTFKSDASKVVSKGMGLKKAYIGKQNQFSISATDAGNNILYVGMYGPKGPCEEFHVKHAGH 2542
                 :..|.||:|.|:|.||.||:|.::..|::..:.||.|:|.||::||:.||||..|||.|:
Zfish  2497 -----STSSSASRVSSRGPGLSKAFISQKASFTVDCSKAGKNMLLVGVHGPQTPCEEILVKHMGN 2556

  Fly  2543 NNYNVQYLVRDRGQYVLLIKWGEEHIPGSPFQIDV 2577
            ..|||.|::::||.|:|.:|||:||||||||.:.|
Zfish  2557 MQYNVSYVLKERGNYILAVKWGDEHIPGSPFTVTV 2591

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cherNP_001262659.2 CH_dFLNA-like_rpt1 175..297 CDD:409160 87/120 (73%)
CH_dFLNA-like_rpt2 298..415 CDD:409164 72/116 (62%)
IG_FLMN 432..527 CDD:214720 49/94 (52%)
IG_FLMN 532..627 CDD:214720 37/94 (39%)
IG_FLMN 631..724 CDD:214720 43/96 (45%)
IG_FLMN 728..815 CDD:214720 49/87 (56%)
IG_FLMN 821..913 CDD:214720 43/91 (47%)
IG_FLMN 918..1001 CDD:214720 33/187 (18%)
Filamin 1012..1098 CDD:395505 29/86 (34%)
IG_FLMN 1109..1196 CDD:214720 60/181 (33%)
Filamin 1197..1293 CDD:395505 34/98 (35%)
IG_FLMN 1302..1392 CDD:214720 50/89 (56%)
IG_FLMN 1395..1490 CDD:214720 35/96 (36%)
IG_FLMN 1494..1587 CDD:214720 36/92 (39%)
IG_FLMN 1606..1682 CDD:214720 31/76 (41%)
IG_FLMN <1731..1791 CDD:214720 32/59 (54%)
IG_FLMN 1797..1884 CDD:214720 52/86 (60%)
IG_FLMN 1978..2067 CDD:214720 56/88 (64%)
Filamin <2111..2159 CDD:395505 25/47 (53%)
IG_FLMN 2172..2260 CDD:214720 55/87 (63%)
IG_FLMN 2265..2354 CDD:214720 40/88 (45%)
IG_FLMN 2360..2448 CDD:214720 45/88 (51%)
IG_FLMN 2488..2577 CDD:214720 46/88 (52%)
flnbXP_017213862.2 SAC6 14..>240 CDD:227401 155/227 (68%)
IG_FLMN 254..349 CDD:214720 50/100 (50%)
IG_FLMN 353..449 CDD:214720 37/95 (39%)
IG_FLMN 452..544 CDD:214720 42/91 (46%)
IG_FLMN 549..632 CDD:214720 47/85 (55%)
IG_FLMN 645..737 CDD:214720 43/91 (47%)
IG_FLMN 742..842 CDD:214720 20/99 (20%)
IG_FLMN 845..941 CDD:214720 16/97 (16%)
IG_FLMN 945..1032 CDD:214720 29/86 (34%)
IG_FLMN 1038..1125 CDD:214720 58/86 (67%)
IG_FLMN 1131..1223 CDD:214720 2/91 (2%)
IG_FLMN 1227..1323 CDD:214720 37/100 (37%)
IG_FLMN 1326..1415 CDD:214720 50/88 (57%)
IG_FLMN 1420..1512 CDD:214720 35/96 (36%)
IG_FLMN 1515..1606 CDD:214720 35/90 (39%)
IG_FLMN 1611..1703 CDD:214720 36/94 (38%)
IG_FLMN <1758..1817 CDD:214720 32/58 (55%)
IG_FLMN 1824..1911 CDD:214720 52/86 (60%)
IG_FLMN 2003..2092 CDD:214720 56/88 (64%)
Filamin <2130..2182 CDD:306978 26/51 (51%)
IG_FLMN 2194..2284 CDD:214720 55/89 (62%)
Filamin 2287..2372 CDD:306978 38/84 (45%)
IG_FLMN 2385..2475 CDD:214720 46/89 (52%)
IG_FLMN 2509..2591 CDD:214720 42/81 (52%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 123 1.000 Domainoid score I5512
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D35998at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
22.010

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