DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GckIII and STK4

DIOPT Version :9

Sequence 1:	NP_650596.1	Gene:	GckIII / 42064	FlyBaseID:	FBgn0266465	Length:	642	Species:	Drosophila melanogaster
Sequence 2:	XP_005260587.1	Gene:	STK4 / 6789	HGNCID:	11408	Length:	503	Species:	Homo sapiens

Alignment Length:	355	Identity:	163/355 - (45%)
Similarity:	232/355 - (65%)	Gaps:	27/355 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 PELIFTKQERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIDDIQQEIMVLSQCDSPYVTK 73
            ||.:|...|::|:||:|.|:|.|...|.|:||||.:.:   |.::.:|.:||.::.|||||:|.|
Human    42 PEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPV---ESDLQEIIKEISIMQQCDSPHVVK 103

  Fly    74 YYGSFLKGTKLWIIMEYLGGGSALDL--MKAGSFEEMHIGIILREVLKGLDYLHSERKLHRDIKA 136
            ||||:.|.|.|||:|||.|.||..|:  ::..:..|..|..||:..||||:|||..||:||||||
Human   104 YYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGLEYLHFMRKIHRDIKA 168

  Fly   137 ANVLLSEQGDVKLADFGVAGQLTNTTSKRNTFVGTPFWMAPEVIKQSQYDAKADIWSLGITAIEL 201
            .|:||:.:|..||||||||||||:|.:||||.:|||||||||||::..|:..||||||||||||:
Human   169 GNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITAIEM 233

  Fly   202 AKGEPPNSELHPMRVLFLIPKNNPPQLTGS--YTKSFKDFVEACLNKDPENRPTAKELLKYPFIK 264
            |:|:||.:::||||.:|:||.|.||.....  ::.:|.|||:.||.|.||.|.||.:||::||::
Human   234 AEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDNFTDFVKQCLVKSPEQRATATQLLQHPFVR 298

  Fly   265 KAKKNAYLIDLID-----RFKKW-----KVSKGDESETESENSDSDSDAKQGGSSQDEPWIMTVK 319
            .||..:.|.|||:     :.|:.     :|.:.||..:|.:..||.:..:..|   ||  :.||:
Human   299 SAKGVSILRDLINEAMDVKLKRQESQQREVDQDDEENSEEDEMDSGTMVRAVG---DE--MGTVR 358

  Fly   320 GLHINSAPRAGVNSFQLQEHELTMQKLMQT 349
               :.|....|.|:  :.||:.|:...:.|
Human   359 ---VASTMTDGANT--MIEHDDTLPSQLGT 383

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GckIII	NP_650596.1	STKc_MST3_like	12..283	CDD:270786	143/284 (50%)
GckIII	NP_650596.1	S_TKc	13..263	CDD:214567	135/253 (53%)
STK4	XP_005260587.1	STKc_MST1_2	42..297	CDD:132943	137/257 (53%)
		S_TKc	46..297	CDD:214567	135/253 (53%)
		Mst1_SARAH	449..496	CDD:288481
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D967913at2759
OrthoFinder	1	1.000	-	-		FOG0000324
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.920