DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GckIII and hpo

DIOPT Version :9

Sequence 1:	NP_650596.1	Gene:	GckIII / 42064	FlyBaseID:	FBgn0266465	Length:	642	Species:	Drosophila melanogaster
Sequence 2:	NP_001261092.1	Gene:	hpo / 37247	FlyBaseID:	FBgn0261456	Length:	669	Species:	Drosophila melanogaster

Alignment Length:	591	Identity:	198/591 - (33%)
Similarity:	287/591 - (48%)	Gaps:	108/591 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 PELIFTKQERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIDDIQQEIMVLSQCDSPYVTK 73
            ||.:|....::|:||:|.|:|.:...:..:||||::.:   |.::.:|.:||.::.|||||||.:
  Fly    38 PEKVFDIMYKLGEGSYGSVYKAVHKESSSIVAIKLVPV---ESDLHEIIKEISIMQQCDSPYVVR 99

  Fly    74 YYGSFLKGTKLWIIMEYLGGGSALDLM--KAGSFEEMHIGIILREVLKGLDYLHSERKLHRDIKA 136
            ||||:.|...|||.|||.|.||..|:|  :..:..|..|..||.:.|:||.|||..||:||||||
  Fly   100 YYGSYFKQYDLWICMEYCGAGSVSDIMRLRKKTLTEDEIATILSDTLQGLVYLHLRRKIHRDIKA 164

  Fly   137 ANVLLSEQGDVKLADFGVAGQLTNTTSKRNTFVGTPFWMAPEVIKQSQYDAKADIWSLGITAIEL 201
            ||:||:.:|..||||||||||||:|.:||||.:|||||||||||::..||..||||||||||:|:
  Fly   165 ANILLNTEGYAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIEEIGYDCVADIWSLGITALEM 229

  Fly   202 AKGEPPNSELHPMRVLFLIPKNNPPQL--TGSYTKSFKDFVEACLNKDPENRPTAKELLKYPFIK 264
            |:|:||..|:||||.:|:||:..||..  ...::..|.|||..||.|:|::|.||.|||::.||:
  Fly   230 AEGKPPYGEIHPMRAIFMIPQKPPPSFREPDRWSTEFIDFVSKCLVKEPDDRATATELLEHEFIR 294

  Fly   265 KAKKNAYLIDLIDRFKKWKVSKGDESETESENSDSDSDAKQGG---SSQDEPWIMTVKGL--HIN 324
            .||..:.|..:::             ||.:......::...||   :||.:.......|:  ||.
  Fly   295 NAKHRSILKPMLE-------------ETCAIREQQRANRSFGGVLAASQAKSLATQENGMQQHIT 346

  Fly   325 SAPRAGVNSFQLQEHELTMQKLMQTTHSPAGGGGVQASPAANALSSSVSAVAASASSVSVITANE 389
            .      |:|......|..:|.          |..|.|.|::|              ..:..|.:
  Fly   347 D------NAFMEDPGTLVPEKF----------GEYQQSSASDA--------------TMIAHAEQ 381

  Fly   390 GVSSASALPPQNSHVHNHNHNNINNNNIRNLSNKHATTTMLNAAPP---PS-------------- 437
            ||...:..|                ..:||||...|.....:||.|   |:
  Fly   382 GVDEGTLGP----------------GGLRNLSKAAAPAAASSAASPLDMPAVDSGTMVELESNLG 430

  Fly   438 --SVTSSSSASELQQKRSSSKPELRQSRSAAPLDQVEDRRASLGLPLQSSVPT---PSTAEQQQQ 497
              .:.|.|..|...:.....||..|.....  |:..:.:.|..|...:..:.|   |:.||||||
  Fly   431 TMVINSDSDDSTTAKNNDDQKPRNRYRPQF--LEHFDRKNAGDGRGDEKPIATEYSPAAAEQQQQ 493

  Fly   498 RRSSQRESFHANNAALVASCSSSSNNHSHEEHVATNHASHVKHSGAGQR-----------LVQTN 551
            ::..|::  ...:...:||.::..||..|...:.....|.:...|..|.           |:...
  Fly   494 QQQQQQQ--QQQDEQHLASGANDLNNWEHNMEMQFQQISAINQYGLQQHQQQQQVLMAYPLMNEQ 556

  Fly   552 SACLNN 557
            ...|||
  Fly   557 LIALNN 562

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GckIII	NP_650596.1	STKc_MST3_like	12..283	CDD:270786	135/274 (49%)
GckIII	NP_650596.1	S_TKc	13..263	CDD:214567	130/253 (51%)
hpo	NP_001261092.1	STKc_MST1_2	38..293	CDD:132943	132/257 (51%)
		S_TKc	42..293	CDD:214567	130/253 (51%)
		Mst1_SARAH	608..655	CDD:288481
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45438547
Domainoid	1	1.000	259	1.000	Domainoid score	I315
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D52072at50557
OrthoFinder	1	1.000	-	-		FOG0000324
OrthoInspector	1	1.000	-	-		otm46741
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.850