Protein Alignment GckIII and hppy

DIOPT Version :10

• Sequence 1: NP_650596.1
• Gene: GckIII / 42064
• FlyBaseID: FBgn0266465
• Length: 642
• Species: Drosophila melanogaster
• Sequence 2: NP_725863.1
• Gene: hppy / 37203
• FlyBaseID: FBgn0263395
• Length: 1218
• Species: Drosophila melanogaster
• Alignment Length: 689
• Identity: 210/689 - (30%)
• Similarity: 327/689 - (47%)
• Gaps: 112/689 - (16%)

  Fly    10 ELIFTKQERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIDDIQQEIMVLSQCDSPYVTKY 74
            |||    ::||.|::|:|:|....::.::.|||:|.||.: |:|..|||||:::..|..|.:..|
  Fly    27 ELI----QKIGSGTYGDVYKAKRIQSNELAAIKVIKLEPS-DDIQIIQQEIIMMRDCRHPNIIAY 86

  Fly    75 YGSFLKGTKLWIIMEYLGGGSALDLMK-AGSFEEMHIGIILREVLKGLDYLHSERKLHRDIKAAN 138
            |||:|:..||||.||:.||||..|:.: .|...|:.|..:.||.||||:||||..|:|||||.||
  Fly    87 YGSYLRRDKLWICMEFCGGGSLQDIYQVTGPLTEVQIAYMCRETLKGLEYLHSMGKMHRDIKGAN 151

  Fly   139 VLLSEQGDVKLADFGVAGQLTNTTSKRNTFVGTPFWMAPEVI---KQSQYDAKADIWSLGITAIE 200
            :||:|.||||||||||:.|:|.|.:||.:|:|||:||||||.   ::..|:...|||:.||||||
  Fly   152 ILLTEYGDVKLADFGVSAQITATINKRKSFIGTPYWMAPEVAAVERKGGYNQLCDIWACGITAIE 216

  Fly   201 LAKGEPPNSELHPMRVLFLIPKN--NPPQLTG--SYTKSFKDFVEACLNKDPENRPTAKELLKYP 261
            ||:.:||..:|||||.|||:.|:  .||.|..  .::.:|.:|::..|.|:|:.||||:.||::|
  Fly   217 LAELQPPMFDLHPMRALFLMSKSGFKPPTLNNKDKWSPTFHNFIKTALTKNPKKRPTAERLLQHP 281

  Fly   262 FIKKAKKNAYLIDLIDRFKK-----WKVSKGDESETES--ENSDSDSDAKQGGSSQDEPWIMTVK 319
            |::.........:|:.:::.     :....|||.....  :...|...::..|.......:.|
  Fly   282 FVQCEMSLRVAKELLQKYQSPNPQFYYYLDGDEESVAGVPQRIASKMTSRTNGVPAQNHTLKT-- 344

  Fly   320 GLHIN-------SAPR---AGVNSFQLQEHELTMQ---KLMQTTHSPAG--------GGGVQASP 363
            |:..|       |:|.   :.::..|..:.||.::   .|...|..|.|        .||.....
  Fly   345 GMTTNSTWNERSSSPETLPSDMSLLQYIDEELKLRATLPLNNDTKDPLGAECSCSSHNGGAAGGG 409

  Fly   364 AANALSSSVSAVAASASSVSVITANEGVSSASALPPQNSHVHNHNHNNINNNNIRNL-------S 421
            ....:.......||:.||.|...|..|.:...   .|..|.|:|:.|:::.:....|       |
  Fly   410 GGGGVGVGAGGAAANGSSSSSGGATVGTTHHQ---HQQHHQHHHHPNHLHQHQSHQLPQQQQQQS 471

  Fly   422 NKHATTTMLNAAPPPSSVTS----------SSSASELQQKRSSSKPELR---------------- 460
            ::.|.....:..|..||::|          |||||.......|:...:|
  Fly   472 HQAAQQEHHHHHPMTSSISSGLVTANANNISSSASLASMPGLSAYLGMRSHVVGHMGMGFGMGLG 536

  Fly   461 -QSRSAAPLDQVEDRRASLGLPLQ---SSVPTP------------STAEQQQQRRSSQRESFHAN 509
             .:.....:|..:|...:..:.:.   ::||..            |.:.....|.||...|..|.
  Fly   537 MSNLRTTSIDADDDELVAADVAMNNAAAAVPGNGSGAGNGSGSGCSASAAHYLRYSSNYRSAAAA 601

  Fly   510 NAALVA-----SCSSSSNNHSHEEHVATNHASHVKHSGAGQRLVQTNSACLNNFLFPVLSDIQRK 569
            .|:..|     |.|:|:|.|.|....::..:|....|...:.|:..||:          .|....
  Fly   602 QASQAAHPHVNSNSNSNNGHGHAPITSSISSSASSASFYNRLLLLDNSS----------GDAVVG 656

  Fly   570 YSGGGSAGSGGSGGRNIGVGS--DIGDLKSVFELAERSS 606
            .:||||:....|||.:.|...  |..:|.::.:.|.:|:
  Fly   657 GNGGGSSNISSSGGASSGTNGLLDKHELDALPQAATKSA 695

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GckIII	NP_650596.1	STKc_MST3_like	12..283	CDD:270786	127/283 (45%)
hppy	NP_725863.1	STKc_MAP4K3_like	25..283	CDD:270788	127/260 (49%)
		CNH	864..1193	CDD:470577