Protein Alignment GckIII and nak1

DIOPT Version :10

• Sequence 1: NP_650596.1
• Gene: GckIII / 42064
• FlyBaseID: FBgn0266465
• Length: 642
• Species: Drosophila melanogaster
• Sequence 2: NP_596023.1
• Gene: nak1 / 2539963
• PomBaseID: SPBC17F3.02
• Length: 652
• Species: Schizosaccharomyces pombe
• Alignment Length: 693
• Identity: 208/693 - (30%)
• Similarity: 329/693 - (47%)
• Gaps: 150/693 - (21%)

  Fly    13 FTKQERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIDDIQQEIMVLS---QCDSPYVTKY 74
            :||.|.:|:||:|.|::||.|.|::.|||||::|:..|||:.|||:|:.|||   |.|...:.||
pombe    10 YTKLELVGRGSYGAVYRGICNLTKETVAIKILNLDTDEDEVSDIQKEVAVLSELKQSDVENIIKY 74

  Fly    75 YGSFLKGTKLWIIMEYLGGGSALDLMKAGSFEEMHIGIILREVLKGLDYLHSERKLHRDIKAANV 139
            :||:|.||.|||||:|..|||...||:||...|..|.:||||.|:.|.::|....:||||||||:
pombe    75 HGSYLVGTNLWIIMDYCHGGSVRTLMEAGPISEPCISLILRETLQALKFIHHAGIIHRDIKAANI 139

  Fly   140 LLSEQGDVKLADFGVAGQLTNTTSKRNTFVGTPFWMAPEVIKQSQ-YDAKADIWSLGITAIELAK 203
            |:|..|:|||.|||||.:|.....||.||:|||:|||||||:..| |:..||||||||||.|:|.
pombe   140 LVSMSGNVKLCDFGVAAELNINRRKRITFIGTPYWMAPEVIRDGQEYNVMADIWSLGITAYEIAT 204

  Fly   204 GEPPNSELHPMRVLFLIPKNNPPQLTGSYTKSFKDFVEACLNKDPENRPTAKELLKYPFIKKAKK 268
            |.||:::..|.|.::||....||:|.|:::...|:|:.:||...|:.|..:.||||..|||:..:
pombe   205 GSPPHAKEDPFRAVYLIAHTAPPRLNGNFSALLKEFIASCLQDVPQRRLDSSELLKSKFIKQYSR 269

  Fly   269 NAY--LIDLIDRFKKWKVSKG------------DESETESENSDSDSDAKQGGSSQDEPWIMTVK 319
            .:.  |.:::.|:..|:.:.|            |.|:.:.|.||:        ::.|:.|
pombe   270 MSISELTNVVKRYDTWQAAGGIPQTLLLGEEADDGSDPDQETSDT--------AASDDGW----- 321

  Fly   320 GLHINSAPRAGVNSFQLQEHELTMQKLMQTTHSPAGGGGVQASPAANALSSSVSAVAASASSV-- 382
                                |....|..|:..|...|.....:.||.:.::....|...:|:|
pombe   322 --------------------EFGTIKQGQSNVSSITGTSTSTTTAATSSTTVTGTVIPKSSTVHE 366

  Fly   383 ----------------SVITANEGVSSASALPPQNSHVH-NHNHNNINNNNIRNLSNKHATT--- 427
                            |.|:.::..|:|.....::|... :::...:.:.:..|||:|.:|.
pombe   367 PPSSNDSHPLLQLFKDSKISDDDSPSNAEGASTEDSKGEVSYSQIELPSLDSSNLSSKKSTIQSK 431

  Fly   428 --------TMLNAAPPPSSVTSSSSASE------LQQKRSS----------SKPELR-------Q 461
                    .:.......:|.|||..:.:      :|::::|          .||.||       |
pombe   432 HTKQAEDYDLFVGRTRSNSKTSSDQSIKRPLPRVVQRQKTSLGKRGISMSPMKPGLRMPSSFDLQ 496

  Fly   462 SRS---------AAPLDQVEDRRASLGLPLQ----SSVPTPSTAEQQQQRRSSQRESFHANNAAL 513
            |||         :.||:....:.:::..||:    .|:|.|.:.......:.|...   |::...
pombe   497 SRSISMGAFEQLSTPLEAPAHKHSAVLQPLEVNRSISIPPPKSISPSILHKPSLES---ASSTPK 558

  Fly   514 VASCSSSSNNHSHEEHVATNHASHVKHSGAGQRLVQTNSACLNNFLFPVLSDIQRKYSGGGSAGS 578
            ::||||:....:      :...:|:.....|...||           |:.:|         :..|
pombe   559 ISSCSSTPKPFN------SKLRAHLPPLSIGSPAVQ-----------PLAND---------NYDS 597

  Fly   579 GGSGGRNIGVGSD----IGDLKSVFELAERSSPGVSDLFMKEL 617
            .|..|.|:.:.:|    :.::|||..|......|..|..:|.|
pombe   598 LGVRGLNMELFNDYPGNMHNIKSVLSLEIDIVLGEMDACLKSL 640

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GckIII	NP_650596.1	STKc_MST3_like	12..283	CDD:270786	133/275 (48%)
nak1	NP_596023.1	Protein Kinases, catalytic domain	8..282	CDD:473864	132/271 (49%)