Protein Alignment GckIII and STK25

DIOPT Version :9

• Sequence 1: NP_650596.1
• Gene: GckIII / 42064
• FlyBaseID: FBgn0266465
• Length: 642
• Species: Drosophila melanogaster
• Sequence 2: NP_001258906.1
• Gene: STK25 / 10494
• HGNCID: 11404
• Length: 426
• Species: Homo sapiens
• Alignment Length: 626
• Identity: 275/626 - (43%)
• Similarity: 325/626 - (51%)
• Gaps: 221/626 - (35%)

  Fly     6 KVDPELIFTKQERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIDDIQQEIMVLSQCDSPY 70
            :||||.:|||.:||||||||||:|||||.|::||||||||||||||||:||||||.|||||||||
Human    13 RVDPEELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPY 77

  Fly    71 VTKYYGSFLKGTKLWIIMEYLGGGSALDLMKAGSFEEMHIGIILREVLKGLDYLHSERKLHRDIK 135
            :|:|:||:||.||||||||||||||||||:|.|..||.:|..||||:||||||||||||:|||||
Human    78 ITRYFGSYLKSTKLWIIMEYLGGGSALDLLKPGPLEETYIATILREILKGLDYLHSERKIHRDIK 142

  Fly   136 AANVLLSEQGDVKLADFGVAGQLTNTTSKRNTFVGTPFWMAPEVIKQSQYDAKADIWSLGITAIE 200
            ||||||||||||||||||||||||:|..||||||||||||||||||||.||.|||||||||||||
Human   143 AANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDFKADIWSLGITAIE 207

  Fly   201 LAKGEPPNSELHPMRVLFLIPKNNPPQLTGSYTKSFKDFVEACLNKDPENRPTAKELLKYPFIKK 265
            |||||||||:|||||||||||||:||.|.|.::|.||:||||||||||..|||||||||:.||.:
Human   208 LAKGEPPNSDLHPMRVLFLIPKNSPPTLEGQHSKPFKEFVEACLNKDPRFRPTAKELLKHKFITR 272

  Fly   266 -AKKNAYLIDLIDRFKKWKVSKGDESETESENSDSDSDAKQGGSSQDEPWIMTVKGLHINSAPRA 329
             .||.::|.:||||:|:|| |:|...|:.||:||.|.:|:.|  .|...|
Human   273 YTKKTSFLTELIDRYKRWK-SEGHGEESSSEDSDIDGEAEDG--EQGPIW--------------- 319

  Fly   330 GVNSFQLQEHELTMQKLMQTTHSPAGGGGVQASPAANALSSSVSAVAASASSVSVITANEGVSSA 394
                                                                             
Human   320 ----------------------------------------------------------------- 319

  Fly   395 SALPPQNSHVHNHNHNNINNNNIRNLSNKHATTTMLNAAPPPSSVTSSSSASELQQKRSSSKPEL 459
             ..||                .||               |.|.|.....:|....||  .::|..
Human   320 -TFPP----------------TIR---------------PSPHSKLHKGTALHSSQK--PAEPVK 350

  Fly   460 RQSRSAAPLDQVEDRRASLGLPLQSSVPTPSTAEQQQQRRSSQRESFHANNAALVASCSSSSNNH 524
            ||.|
Human   351 RQPR------------------------------------------------------------- 354

  Fly   525 SHEEHVATNHASHVKHSGAGQRLVQTNSACLNNFLFPVLSDIQRKY-SGGGSAGSGGSGGRNIGV 588
                                       |.||:..:.||..:::.|: ..|||.|:
Human   355 ---------------------------SQCLSTLVRPVFGELKEKHKQSGGSVGA---------- 382

  Fly   589 GSDIGDLKSVFELAERSSPGVSDLFMKELIHMLVPGYSETR 629
               :.:|::.|.|||.|.||:||..|..|:.. |..:|..|
Human   383 ---LEELENAFSLAEESCPGISDKLMVHLVER-VQRFSHNR 419

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GckIII	NP_650596.1	STKc_MST3_like	12..283	CDD:270786	218/271 (80%)
		S_TKc	13..263	CDD:214567	208/249 (84%)
STK25	NP_001258906.1	STKc_STK25	15..291	CDD:270810	221/275 (80%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	291..355		27/268 (10%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143077
Domainoid	1	1.000	440	1.000	Domainoid score	I554
eggNOG	1	0.900	-	-		E1_KOG0201
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	516	1.000	Inparanoid score	I1299
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D418754at33208
OrthoFinder	1	1.000	-	-		FOG0000324
OrthoInspector	1	1.000	-	-		otm41047
orthoMCL	1	0.900	-	-		OOG6_100860
Panther	1	1.100	-	-	LDO	PTHR48012
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R966
SonicParanoid	1	1.000	-	-		X488
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.790