Protein Alignment Keap1 and KLHL13

DIOPT Version :10

• Sequence 1: NP_732202.2
• Gene: Keap1 / 42062
• FlyBaseID: FBgn0038475
• Length: 776
• Species: Drosophila melanogaster
• Sequence 2: NP_001161771.1
• Gene: KLHL13 / 90293
• HGNCID: 22931
• Length: 658
• Species: Homo sapiens
• Alignment Length: 621
• Identity: 164/621 - (26%)
• Similarity: 277/621 - (44%)
• Gaps: 45/621 - (7%)

  Fly    42 ISCGGRFGSAHSTLDDHDATDDDMTFCMSNYAKEALKMMYMMRSHGMLTDVVLEV--KKELFPAH 104
            :|.||......|.|....| .....|..:.::...|:....:|..|:|.||.|..  ..:.||.|
Human    48 LSLGGSEMGLSSHLQSSKA-GPTRIFTSNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVH 111

  Fly   105 KVVLSAASPYFKAMFTGGLKESEMSRVQLQGVCPTAMSRILYFMYTGQIRVTEVTVCQLLPAATM 169
            :|::::||.|||||||||:||.::..::|.||....:.:|:.|:||.::.:....:...|.||:.
Human   112 RVMMASASDYFKAMFTGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASF 176

  Fly   170 FQVPNVIDACCAFLERQLDPTNAIGIAHFAEQHGCVELQKKANVFIERNFTQVCQEEEFLQLSAY 234
            .|:..|:|.|..||...:...|.:.:...|..:...|:.|..|.|:.:||..:....|||:|...
Human   177 LQILPVLDFCKVFLISGVTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFE 241

  Fly   235 QLIALIRRDELNVQEEREVYNAVLKWVKYDEDNRHCKME---HILGAVRCQFLTPNFLKEQMKNC 296
            :|..::..:.|....|.|::.|..:|::.:|.    :|:   .::..:|...:||..|...::..
Human   242 RLAFVLSSNSLKHCTELELFKATCRWLRLEEP----RMDFAAKLMKNIRFPLMTPQELINYVQTV 302

  Fly   297 DVLRKVPACREYL--AKIFKDLTLHKCPGVKERT---PNTTRMIFVAGGFFRHSLDI---LEAYN 353
            |.:|....|...|  |..::.:...:.....:||   .:||.:: ..||..|..|.:   |..|:
Human   303 DFMRTDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDTTHLV-TLGGVLRQQLVVSKELRMYD 366

  Fly   354 VDDMTWTTLANLRIPRSGLGAAFLKGKFYAVGGRNNNIGSSYDS------DWVDRYSAVTETWRP 412
            .....|.:||.:..||...|.|.:....|.|||::|     ||:      |.|.|:......|..
Human   367 EKAHEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSN-----YDTKGKTAVDTVFRFDPRYNKWMQ 426

  Fly   413 CAPMSVPRHRVGVAVMDELMYAVGGSAGMEYHNTVEYYDPDLDRWTLVQPMHAKRLGVGVVVVNR 477
            .|.::..|....::.:...:|||||........|||.|:|..:.||.|..|.....|....|...
Human   427 VASLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAGTVYGG 491

  Fly   478 LLYAIGGFDGNERLASVECYHPENNEWSFLPPLQTGRSGAGVAAINQYIYVVGG--FDGTR---Q 537
            ::|..||...:.....:.|:.|:.::|....|:.|.|....:..:.:.:||:||  |.||.   .
Human   492 VMYISGGITHDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGNHFRGTSDYDD 556

  Fly   538 LATVERYDTENDTWDMVAPIQIARSALSLTPLDEKLYAIGGFDGNN--FLSIVEVYDPRTNTWTT 600
            :.:.|.|....|.|..:|.:...:|.:.:...:.|:|.:||:..||  .:.||:.|||..:.|..
Human   557 VLSCEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPDKDEWHK 621

  Fly   601 GTPLKSGRSGHASAVIYQPACSTTFMDYEDSDAPHP 636
            ...|.....|..       ||:.|....|:: .|.|
Human   622 VFDLPESLGGIR-------ACTLTVFPPEET-TPSP 649

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Keap1	NP_732202.2	PHA03098	92..599	CDD:222983	143/532 (27%)
		KELCH repeat	369..416	CDD:276965	15/52 (29%)
		KELCH repeat	420..463	CDD:276965	14/42 (33%)
		KELCH repeat	467..510	CDD:276965	8/42 (19%)
		KELCH repeat	514..558	CDD:276965	13/48 (27%)
		KELCH repeat	561..606	CDD:276965	14/46 (30%)
KLHL13	NP_001161771.1	BTB_POZ_KLHL9_13	72..199	CDD:349548	41/126 (33%)
		PHA03098	95..638	CDD:222983	149/559 (27%)
		KELCH repeat	382..430	CDD:276965	15/52 (29%)
		KELCH repeat	434..478	CDD:276965	14/43 (33%)
		KELCH repeat	481..526	CDD:276965	9/44 (20%)
		KELCH repeat	528..577	CDD:276965	13/48 (27%)
		KELCH repeat	580..627	CDD:276965	14/46 (30%)