DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Keap1 and KBTBD6

DIOPT Version :10

Sequence 1:NP_732202.2 Gene:Keap1 / 42062 FlyBaseID:FBgn0038475 Length:776 Species:Drosophila melanogaster
Sequence 2:NP_690867.3 Gene:KBTBD6 / 89890 HGNCID:25340 Length:674 Species:Homo sapiens


Alignment Length:576 Identity:142/576 - (24%)
Similarity:229/576 - (39%) Gaps:140/576 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    77 LKMMYMMRSHGMLTDVVLEV--------KKELFPAHKVVLSAASPYFKAMFTGGLKESEMSRVQL 133
            ||..|..|   :|.||.:||        ...|||.::.||:||.||||:|||||:.||:.:.|.:
Human    53 LKSFYDAR---LLCDVTIEVVTPGSGPGTGRLFPCNRNVLAAACPYFKSMFTGGMYESQQASVTM 114

  Fly   134 QGVCPTAMSRILYFMYTGQIRVTEVTVCQLLPAATMFQVPNVIDACCAFLERQLDPTNAIGIAHF 198
            ..|...:...::.:.|||::.::|..|.:|..|:.|.|:..|.:||.:||.|:||.||...|..|
Human   115 HDVDAESFEVLVDYCYTGRVSLSEANVERLYAASDMLQLEYVREACASFLARRLDLTNCTAILKF 179

  Fly   199 AEQHGCVELQKKANVFIERNFTQV-----CQEEEFLQLSAYQLIALIRRDELNVQEEREVYNAVL 258
            |:..|..:|:.:|..:|.:||.|:     .:||....|:..||:|::|.|.|:|:.|:.|.:..:
Human   180 ADAFGHRKLRSQAQSYIAQNFKQLSHMGSIREETLADLTLAQLLAVLRLDSLDVESEQTVCHVAV 244

  Fly   259 KWVKYDEDNRHCKMEHILGAVRCQFLTPNFLKEQMKNCDVLRKVPACREYLAKIFKDLTLHKCPG 323
            :|::.....|......:...||..    :|.:|.....:.|...|..::|            |  
Human   245 QWLEAAPKERGPSAAEVFKCVRWM----HFTEEDQDYLEGLLTKPIVKKY------------C-- 291

  Fly   324 VKERTPNTTRMIFVAGGFFRHSLDILEA---YNVDDMTWTTLANLRIPRSGLGAAFLKGKFYAVG 385
                                  ||::|.   ....|:.:.:|  :.:|.|...::.......|..
Human   292 ----------------------LDVIEGALQMRYGDLLYKSL--VPVPNSSSSSSSSNSLVSAAE 332

  Fly   386 GRNNNIGS---------SYDSD---WVDRYSAVTETWRPCAPMSVPRHRVGVAVMDELMYAVGGS 438
            .....:|.         .:..|   ..|.||.  :.::..:|::...|...|..:...:      
Human   333 NPPQRLGMCAKEMVIFFGHPRDPFLCCDPYSG--DLYKVPSPLTCLAHTRTVTTLAVCI------ 389

  Fly   439 AGMEYHNTVEYYDPDLDRWTLVQPMHAKRLGVGVVVVNRLLYAIGGFDGNERLASVECYHPENNE 503
                        .||.|.:...||    |..:.|                        |.|..|.
Human   390 ------------SPDHDIYLAAQP----RTDLWV------------------------YKPAQNS 414

  Fly   504 WSFLPPLQTGRSGAGVAAINQYIYVVGGFD---GTRQLATVERYDTENDTWDMVAPIQIARSALS 565
            |..|......|.|..||.:|.|||::||.|   |.: |..||.|:.:.:.|.:|||:..:..:..
Human   415 WQQLADRLLCREGMDVAYLNGYIYILGGRDPITGVK-LKEVECYNVKRNQWALVAPLPHSFLSFD 478

  Fly   566 LTPLDEKLYAIGGFDGNNFLSIVEVYDPRTNTWTTGTPLKSGRSGHASAVIYQPAC 621
            |..:.:.|||:..       ..:..|||..|.|.....||...        :|.||
Human   479 LMVIRDYLYALNS-------KRMFCYDPSHNMWLKCVSLKRND--------FQEAC 519

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Keap1NP_732202.2 PHA03098 92..599 CDD:222983 130/537 (24%)
KELCH repeat 369..416 CDD:276965 7/58 (12%)
KELCH repeat 420..463 CDD:276965 6/42 (14%)
KELCH repeat 467..510 CDD:276965 7/42 (17%)
KELCH repeat 514..558 CDD:276965 20/46 (43%)
KELCH repeat 561..606 CDD:276965 10/44 (23%)
KBTBD6NP_690867.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..28
BTB_POZ_KBTBD6_7 37..178 CDD:349582 49/127 (39%)
PHA03098 55..553 CDD:222983 140/574 (24%)
BACK_KBTBD6_7 168..270 CDD:350557 30/105 (29%)
Kelch 1 386..435 16/94 (17%)
KELCH repeat 425..471 CDD:276965 20/46 (43%)
Kelch 2 436..484 16/48 (33%)
Kelch 3 486..523 13/49 (27%)
KELCH repeat 512..551 CDD:276965 3/16 (19%)
Kelch 4 524..564
Kelch 5 567..616
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 631..674
ATG8 interaction motif (AIM). /evidence=ECO:0000269|PubMed:25684205 668..671
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.