Protein Alignment Keap1 and KLHL6

DIOPT Version :10

• Sequence 1: NP_732202.2
• Gene: Keap1 / 42062
• FlyBaseID: FBgn0038475
• Length: 776
• Species: Drosophila melanogaster
• Sequence 2: NP_569713.2
• Gene: KLHL6 / 89857
• HGNCID: 18653
• Length: 621
• Species: Homo sapiens
• Alignment Length: 557
• Identity: 157/557 - (28%)
• Similarity: 260/557 - (46%)
• Gaps: 40/557 - (7%)

  Fly    83 MRSHGMLTDVVLEVKKELFPAHKVVLSAASPYFKAMFTGGLKESEMSRVQLQGVCPTAMSRILYF 147
            :|....||||:|.|..:.|..|:|||:|||.||:|||...|||....|:.::||....|..:|.:
Human    65 LRMENALTDVILCVDIQEFSCHRVVLAAASNYFRAMFCNDLKEKYEKRIIIKGVDAETMHTLLDY 129

  Fly   148 MYTGQIRVTEVTVCQLLPAATMFQVPNVIDACCAFLERQLDPTNAIGIAHFAEQHGCVELQKKAN 212
            .||.:..:|:..|.::|.||.:||...::|||.:||...|:|.|.:||...|:.|....|:|:..
Human   130 TYTSKALITKQNVQRVLEAANLFQFLRMVDACASFLTEALNPENCVGILRLADTHSLDSLKKQVQ 194

  Fly   213 VFIERNFTQVCQEEEFLQLSAYQLIALIRRDELNVQEEREVYNAVLKWVKYDEDNRHCKMEHILG 277
            .:|.:||.|:...||||.|....|..:::.|:|.|.||.:|:..|:.||::....|.|.:.::|.
Human   195 SYIIQNFVQILNSEEFLDLPVDTLHHILKSDDLYVTEEAQVFETVMSWVRHKPSERLCLLPYVLE 259

  Fly   278 AVRCQFLTPNFLKEQMKNCDVLRKVPACREYLAKIFKDLTLHKCPG---VKERT-PN----TTRM 334
            .||...|.|.:..|.::...::|:.|.    :..:.::..::...|   :.||| |.    .:.:
Human   260 NVRLPLLDPWYFVETVEADPLIRQCPE----VFPLLQEARMYHLSGNEIISERTKPRMHEFQSEV 320

  Fly   335 IFVAGGFFRHSLDILEAYNVDDMTWTTLANLRIPRS------------GLGAAFLKGKFYAVGGR 387
            ..:.||..:....:.|...:|.:..:.|...::|.:            ......||.:.|..||:
Human   321 FMIIGGCTKDERFVAEVTCLDPLRRSRLEVAKLPLTEHELESENKKWVEFACVTLKNEVYISGGK 385

  Fly   388 NNNIGSSYDSDWVDRYSAVTETWRPCAPMSVPRHRVGVAVMDELMYAVGGSAGMEYHNTVEYYDP 452
            .    :.:|   |.:|::....|.....:::.|.|..:.|:...:|.:||..|::..|.||.|||
Human   386 E----TQHD---VWKYNSSINKWIQIEYLNIGRWRHKMVVLGGKVYVIGGFDGLQRINNVETYDP 443

  Fly   453 DLDRWTLVQPMHAKRLGVGVVVVNRLLYAIGGFDGNERLAS--VECYHPENNEWSFLPPLQTGRS 515
            ..:.|:...|:.............:.||.||| ..|.:||:  .:||.|..|:||....:.....
Human   444 FHNCWSEAAPLLVHVSSFAATSHKKKLYVIGG-GPNGKLATDKTQCYDPSTNKWSLKAAMPVEAK 507

  Fly   516 GAGVAAINQYIYVVGGFDGTRQLATVERYDTENDTWDMVAPIQIARSALSLTPLDEKLYAIGGFD 580
            .....:....||||||     .:..:..|....|:|.:|..:...|::..:.|.:.:||..||.|
Human   508 CINAVSFRDRIYVVGG-----AMRALYAYSPLEDSWCLVTQLSHERASCGIAPCNNRLYITGGRD 567

  Fly   581 -GNNFLSIVEVYDPRTNTWTTGTPLKSGRSGHASAVI 616
             .|..::.|..:||.....|....|..|.|.|.|..|
Human   568 EKNEVIATVLCWDPEAQKLTEECVLPRGVSHHGSVTI 604

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Keap1	NP_732202.2	PHA03098	92..599	CDD:222983	146/529 (28%)
		KELCH repeat	369..416	CDD:276965	9/58 (16%)
		KELCH repeat	420..463	CDD:276965	14/42 (33%)
		KELCH repeat	467..510	CDD:276965	14/44 (32%)
		KELCH repeat	514..558	CDD:276965	10/43 (23%)
		KELCH repeat	561..606	CDD:276965	13/45 (29%)
KLHL6	NP_569713.2	BTB_POZ_KLHL6	48..176	CDD:349545	45/110 (41%)
		PHA03098	86..565	CDD:222983	135/495 (27%)
		BACK_KLHL6	169..276	CDD:350521	36/106 (34%)
		Kelch 1	320..367		6/46 (13%)
		KELCH repeat	370..407	CDD:276965	9/43 (21%)
		Kelch 2	378..421		10/49 (20%)
		KELCH repeat	411..455	CDD:276965	15/43 (35%)
		Kelch 3	422..468		12/45 (27%)
		KELCH repeat	458..504	CDD:276965	14/46 (30%)
		Kelch 4	470..516		14/46 (30%)
		KELCH repeat	506..546	CDD:276965	10/44 (23%)
		Kelch 5	517..558		12/45 (27%)
		KELCH repeat	548..593	CDD:276965	12/44 (27%)
		Kelch_1	548..585	CDD:396078	11/36 (31%)
		Kelch 6	560..606		16/45 (36%)