DRSC/TRiP Functional Genomics Resources

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Protein Alignment Keap1 and KBTBD7

DIOPT Version :10

Sequence 1:NP_732202.2 Gene:Keap1 / 42062 FlyBaseID:FBgn0038475 Length:776 Species:Drosophila melanogaster
Sequence 2:NP_115514.2 Gene:KBTBD7 / 84078 HGNCID:25266 Length:684 Species:Homo sapiens


Alignment Length:576 Identity:148/576 - (25%)
Similarity:239/576 - (41%) Gaps:140/576 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    77 LKMMYMMRSHGMLTDVVLEV--------KKELFPAHKVVLSAASPYFKAMFTGGLKESEMSRVQL 133
            ||..|..|   :|.||.:||        ...||..::.||:||.||||:|||||:.||:.:.|.:
Human    53 LKSFYDAR---LLCDVTIEVVTPGSGPGTGRLFSCNRNVLAAACPYFKSMFTGGMYESQQASVTM 114

  Fly   134 QGVCPTAMSRILYFMYTGQIRVTEVTVCQLLPAATMFQVPNVIDACCAFLERQLDPTNAIGIAHF 198
            ..|...:...::.:.|||::.::|..|.:|..|:.|.|:..|.:||.:||.|:||.||...|..|
Human   115 HDVDAESFEVLVDYCYTGRVSLSEANVQRLYAASDMLQLEYVREACASFLARRLDLTNCTAILKF 179

  Fly   199 AEQHGCVELQKKANVFIERNFTQV-----CQEEEFLQLSAYQLIALIRRDELNVQEEREVYNAVL 258
            |:.....:|:.:|..:|..||.|:     .:||....|:..||:|::|.|.|:::.||.|.:..:
Human   180 ADAFDHHKLRSQAQSYIAHNFKQLSRMGSIREETLADLTLAQLLAVLRLDSLDIESERTVCHVAV 244

  Fly   259 KWVKYDEDNRHCKMEHILGAVRCQFLTPNFLKEQMKNCDVLRKVPACREYLAKIFKDLTLHKCPG 323
            :|::.....|......:...||..    :|.:|.....:.|...|..::|            |  
Human   245 QWLEAAAKERGPSAAEVFKCVRWM----HFTEEDQDYLEGLLTKPIVKKY------------C-- 291

  Fly   324 VKERTPNTTRMIFVAGGFFRHSLDILEA---YNVDDMTWTTLANLRIPRSGLGAAFLKGKFYAVG 385
                                  ||::|.   ....|:.:.:|  :.:|.|...::          
Human   292 ----------------------LDVIEGALQMRYGDLLYKSL--VPVPNSSSSSS---------- 322

  Fly   386 GRNNNIGSSYDSDWVDRYSAVTETWRPCAPMSVPRHRVGVAVMDELMYAVGGSAGMEYHNTVEY- 449
             .:|::.|:.::                     |..|:|:.. .|::...|       |....: 
Human   323 -SSNSLVSAAEN---------------------PPQRLGMCA-KEMVIFFG-------HPRDPFL 357

  Fly   450 -YDP-DLDRWTLVQPM----HAKRLGVGVVVVNRLLYAIGGFDGNERLAS-----VECYHPENNE 503
             ||| ..|.:|:..|:    |.|.:....|.|:.        |.:..||:     :..|.|..|.
Human   358 CYDPYSGDIYTMPSPLTSFAHTKTVTSSAVCVSP--------DHDIYLAAQPRKDLWVYKPAQNS 414

  Fly   504 WSFLPPLQTGRSGAGVAAINQYIYVVGGFD---GTRQLATVERYDTENDTWDMVAPIQIARSALS 565
            |..|......|.|..||.:|.|||::||.|   |.: |..||.|..:.:.|.:|||:..:..:..
Human   415 WQQLADRLLCREGMDVAYLNGYIYILGGRDPITGVK-LKEVECYSVQRNQWALVAPVPHSFYSFE 478

  Fly   566 LTPLDEKLYAIGGFDGNNFLSIVEVYDPRTNTWTTGTPLKSGRSGHASAVIYQPAC 621
            |..:...|||:   :....|    .|||..|.|.....||  ||.      :|.||
Human   479 LIVVQNYLYAV---NSKRML----CYDPSHNMWLNCASLK--RSD------FQEAC 519

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Keap1NP_732202.2 PHA03098 92..599 CDD:222983 134/537 (25%)
KELCH repeat 369..416 CDD:276965 3/46 (7%)
KELCH repeat 420..463 CDD:276965 10/45 (22%)
KELCH repeat 467..510 CDD:276965 10/47 (21%)
KELCH repeat 514..558 CDD:276965 20/46 (43%)
KELCH repeat 561..606 CDD:276965 11/44 (25%)
KBTBD7NP_115514.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..27
BTB_POZ_KBTBD6_7 37..178 CDD:349582 48/127 (38%)
PHA03098 55..544 CDD:222983 146/574 (25%)
BACK_KBTBD6_7 168..270 CDD:350557 29/105 (28%)
KELCH repeat 384..421 CDD:276965 10/44 (23%)
Kelch 1 386..435 14/56 (25%)
KELCH repeat 425..471 CDD:276965 20/46 (43%)
Kelch 2 436..484 16/48 (33%)
KELCH repeat 474..511 CDD:276965 10/43 (23%)
Kelch 3 486..523 16/49 (33%)
KELCH repeat 512..551 CDD:276965 5/14 (36%)
Kelch 4 524..564
Kelch 5 567..616
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 630..666
ATG8 interaction motif (AIM). /evidence=ECO:0000269|PubMed:25684205 668..671
Blue background indicates that the domain is not in the aligned region.

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