Protein Alignment Keap1 and klhl40b

DIOPT Version :10

• Sequence 1: NP_732202.2
• Gene: Keap1 / 42062
• FlyBaseID: FBgn0038475
• Length: 776
• Species: Drosophila melanogaster
• Sequence 2: NP_001410734.2
• Gene: klhl40b / 795319
• ZFINID: ZDB-GENE-060227-1
• Length: 618
• Species: Danio rerio
• Alignment Length: 575
• Identity: 152/575 - (26%)
• Similarity: 258/575 - (44%)
• Gaps: 61/575 - (10%)

  Fly    80 MYMMRSHGMLTDVVLEVKKELFPAHKVVLSAASPYFKAMFTGGLKESEMSRVQLQGVCPTAMSRI 144
            :|.:....|:.|.||::|.:.||.|::||:|.|.||:|.|..|::||:...:.|:.|.|..|..|
Zfish    23 LYDLLESDMMVDCVLKIKDKEFPCHRLVLAACSSYFRAFFKSGVEESKQREIVLEDVEPGVMGII 87

  Fly   145 LYFMYTGQIRVTEVTVCQLLPAATMFQVPNVIDACCAFLERQLDPTNAIGIAHFAEQHGCVELQK 209
            |.::||..|.|||..|..:...:.|.|:|::...|.:||:::|..:|.:.|........|..|..
Zfish    88 LKYLYTSNINVTEQNVQDIFALSNMLQIPSIFTVCVSFLQKRLSLSNCLAIFRLGLMLDCPRLAI 152

  Fly   210 KANVFIERNFTQVCQEEEFLQLSAYQLIALIRRDELNVQEEREVYNAVLKWVKYDEDNRHCKMEH 274
            .|..|....|..:.::||||||:..:|.|::..|.|||:.|::|:.|::|||.:|::||...:..
Zfish   153 SARNFACERFQFITRDEEFLQLTPSELAAVLASDSLNVETEQDVFEALIKWVGHDQENRIGDLPD 217

  Fly   275 ILGAVRCQFLTPNFLKEQMKNCDVLRKVPACREYLAKIFKDLTLHKCPGVK-------------- 325
            :|..:|.:.:..::..:.::..:.|...|...:.| ::.||....|.|.:|
Zfish   218 LLDCIRLRLVPRDYFVKNVEKHEWLSSNPEITKKL-QLVKDAHAGKLPELKKTKNKKSPSEEGQK 281

  Fly   326 --------------ERTPNTTRMIFVAGGFFRHSLDILE-----AYN-VDDMTWTTLANLRIPRS 370
                          ||.|.........|.|.|..:.::.     ||: ..:..:....:.:||::
Zfish   282 KGDEEEVEEEEEQEERLPGILNDNLRFGMFLRELIFLINDSASVAYDPTGNDCYVASVSTQIPKN 346

  Fly   371 GLGAAFLKGKFYAVGG-------RNNNIGSSYDSDWVDRYSAVTETWRPCAPMSVPRHRVGVAVM 428
            .......:.:.:..||       ::..|.|     :..::...:..|....|:..||...|:...
Zfish   347 HCSLVTKENQIFVAGGLFFDEQSKDEQIYS-----YFLQFDPASSDWMGMPPIPSPRFLFGMGEA 406

  Fly   429 DELMYAVGG---SAGMEYHNTVEYYDPDLDRWTLVQPMHAKRLGVGVVVVNRLLYAIGGFDGNER 490
            :..::.:||   ..|....|||..||....:|....|:.....|.|||..|.::|.|||...|:.
Zfish   407 ENFIFVIGGREMKEGENILNTVMVYDRQFLKWAESDPLPYLVYGHGVVSHNEMIYVIGGKGENKE 471

  Fly   491 LASVEC-YHPENNEWSFLPPLQTGRSGAGVAAINQYIYVVGGFDGTRQLATVERYDTENDTWDMV 554
            ..:..| |..:.::|....||.|.||..||......||||.|...:....:.|.||.:.:.|...
Zfish   472 CLNRVCAYDIKTHQWKDFAPLNTARSLFGVTIHKNNIYVVAGVTDSGLTGSAEVYDIKTNKWSEF 536

  Fly   555 APIQIARSALSLTPLDEKLYAIGGF------DGNNFLSI----VEVYDPRTNTWT 599
            ......||:|||..:...|||:|||      |.::.:.:    :..||....||:
Zfish   537 VEFPQDRSSLSLVSVSGVLYAVGGFAMFPKEDSDDLMPLEMNDIWRYDESERTWS 591

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Keap1	NP_732202.2	PHA03098	92..599	CDD:222983	148/561 (26%)
		KELCH repeat	369..416	CDD:276965	5/53 (9%)
		KELCH repeat	420..463	CDD:276965	11/45 (24%)
		KELCH repeat	467..510	CDD:276965	13/43 (30%)
		KELCH repeat	514..558	CDD:276965	13/43 (30%)
		KELCH repeat	561..606	CDD:276965	16/49 (33%)
klhl40b	NP_001410734.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	264..297		2/32 (6%)
		Kelch 1	356..408		9/56 (16%)
		Kelch 2	409..458		14/48 (29%)
		Kelch 3	459..506		15/46 (33%)
		Kelch 4	508..553		14/44 (32%)
		Kelch 5	555..608		11/37 (30%)