Protein Alignment Keap1 and klhl24

DIOPT Version :10

• Sequence 1: NP_732202.2
• Gene: Keap1 / 42062
• FlyBaseID: FBgn0038475
• Length: 776
• Species: Drosophila melanogaster
• Sequence 2: NP_001072337.1
• Gene: klhl24 / 779790
• XenbaseID: XB-GENE-1000313
• Length: 600
• Species: Xenopus tropicalis
• Alignment Length: 565
• Identity: 169/565 - (29%)
• Similarity: 264/565 - (46%)
• Gaps: 34/565 - (6%)

  Fly    70 SNYAKEALKMMYMMRSHGMLTDVVLEVKKELFPAHKVVLSAASPYFKAMFTGGLKESEMSRVQLQ 134
            |::::..|::....|.:.:.|||::.|:...||.|:.:|||.|.||:|||....:||....|::.
 Frog    46 SSHSESILQVFNEFRENRLFTDVIICVEGREFPCHRAILSACSSYFRAMFCNDHRESREMLVEIN 110

  Fly   135 GVCPTAMSRILYFMYTGQIRVTEVTVCQLLPAATMFQVPNVIDACCAFLERQLDPTNAIGIAHFA 199
            |:...||...|.::|||::::|...|..|...:::||:..:.|||..|||.||||.|.:||.|||
 Frog   111 GIFAEAMDCFLQYVYTGRVKITTENVQYLFETSSLFQISVLRDACAKFLEEQLDPCNCLGIQHFA 175

  Fly   200 EQHGCVELQKKANVFIERNFTQVCQEEEFLQLSAYQLIALIRRDELNVQEEREVYNAVLKWVKYD 264
            :.|....|..|...|.::.|..|.|.||||:|...:||..:..|||.|.:|..|:.||::||.:.
 Frog   176 DTHSLKTLFTKCKSFAQQAFEDVVQHEEFLELGKAELIDYVSTDELVVSKEELVFEAVMRWVYHH 240

  Fly   265 EDNRHCKMEHILGAVRCQFLTPNFLKEQMKNCDVLRKVPACREYL--AKIFKDLTLHKCPGVKER 327
            .|.|...::.:|..||...|.||:..:.::...:::..|.|.:.|  |:.:..|      |.:..
 Frog   241 VDVRRPMLQELLTHVRLPLLHPNYFVQTVEVDQIIQNAPDCYQLLHEARRYHIL------GNEMM 299

  Fly   328 TPNT--------TRMIFVAGGFFR---HSLDILEAYNVDDMTWTTLANL-RIPRSGLGAAFLKGK 380
            :|.|        :.:|.|.||..|   .:|...|.|:.....|.:||.| ...:|......|:..
 Frog   300 SPRTRPRRSTGYSEVIVVVGGCERVGGFNLPYTECYDPVTGEWKSLAKLPEFTKSEYAVCALRND 364

  Fly   381 FYAVGGRNNNIGSSYDSDWVDRYSAVTETWRPCAPMSVPRHRVGVAVMDELMYAVGGSAGMEYHN 445
            ....|||.|    |.|. |:  |::....|...|.::..|.|..:||:...:|.|||..|....:
 Frog   365 ILVSGGRIN----SRDV-WI--YNSQLNIWIRVASLNKGRWRHKMAVLLGKVYVVGGYDGQNRLS 422

  Fly   446 TVEYYDPDLDRWTLVQPMHAKRLGVGVV-VVNRLLYAIGGFDGNERLASVECYHPENNEWSFLPP 509
            :||.||...:|||.|.|:........|. .|.:|....||.|.|.....|:||.|:||.|.....
 Frog   423 SVESYDSFSNRWTDVAPLKEAVSSPAVASCVGKLFVVGGGPDDNTCSDKVQCYDPDNNTWLLRAS 487

  Fly   510 LQTGRSGAGVAAINQYIYVVGGFDGTRQLATVERYDTENDTWDMVAPIQIARSALSLTPLDEKLY 574
            :...:......::|..|||.||.     ...:..||...|.|..|......:....::..:.|::
 Frog   488 IPIAKRCITAVSLNNLIYVAGGL-----TKAIYCYDPVEDYWIHVQNTFTRQENCGMSVCNGKIF 547

  Fly   575 AIGGFDGN-NFLSIVEVYDPRTNTWTTGTPLKSGRSGHASAVIYQ 618
            .:||...| .....:..|||.|:..|....:....|.|....|::
 Frog   548 ILGGRGENGEATDTILCYDPATSIITGVAAMPRPVSYHGCVTIHR 592

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Keap1	NP_732202.2	PHA03098	92..599	CDD:222983	160/522 (31%)
		KELCH repeat	369..416	CDD:276965	12/46 (26%)
		KELCH repeat	420..463	CDD:276965	17/42 (40%)
		KELCH repeat	467..510	CDD:276965	14/43 (33%)
		KELCH repeat	514..558	CDD:276965	11/43 (26%)
		KELCH repeat	561..606	CDD:276965	9/45 (20%)
klhl24	NP_001072337.1	BTB_POZ_KLHL24_KRIP6	48..168	CDD:349562	43/119 (36%)
		PHA03098	59..566	CDD:222983	159/524 (30%)
		KELCH repeat	354..393	CDD:276965	12/45 (27%)
		KELCH repeat	397..441	CDD:276965	18/43 (42%)
		KELCH repeat	444..489	CDD:276965	14/44 (32%)
		KELCH repeat	492..529	CDD:276965	11/41 (27%)
		KELCH repeat	536..578	CDD:276965	9/41 (22%)
		Kelch	545..591	CDD:128874	11/45 (24%)