DRSC/TRiP Functional Genomics Resources

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Protein Alignment Keap1 and klhl24a

DIOPT Version :10

Sequence 1:NP_732202.2 Gene:Keap1 / 42062 FlyBaseID:FBgn0038475 Length:776 Species:Drosophila melanogaster
Sequence 2:NP_001070808.1 Gene:klhl24a / 768198 ZFINID:ZDB-GENE-061013-572 Length:599 Species:Danio rerio


Alignment Length:624 Identity:178/624 - (28%)
Similarity:278/624 - (44%) Gaps:67/624 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly    20 NHK---GYPCRPE------EAEMSNTSESCSISCGGRFGSAHSTLDDHDATDDDMTFCMSNYAKE 75
            ||:   |.|..|.      |.|....|:..:.|.|                        |::::.
Zfish    10 NHENSGGVPESPAIKRKVFEMETKTLSDVFNFSSG------------------------SSHSES 50

  Fly    76 ALKMMYMMRSHGMLTDVVLEVKKELFPAHKVVLSAASPYFKAMFTGGLKESEMSRVQLQGVCPTA 140
            .|::....|...:.|||::.|:...||.|:.||||.|.||:|||....:||....|::.|:...|
Zfish    51 VLQVFNEFRDSRLFTDVIISVQGREFPCHRAVLSACSSYFRAMFCNDHRESREMVVEINGIQADA 115

  Fly   141 MSRILYFMYTGQIRVTEVTVCQLLPAATMFQVPNVIDACCAFLERQLDPTNAIGIAHFAEQHGCV 205
            |...|.::|||:..:|.:.|..|...:::||:..:.|||..|||.||||.|.:||..||:.|...
Zfish   116 MDTFLQYVYTGRACITTLNVQFLFETSSLFQITTLRDACAKFLEEQLDPCNCLGIQRFADAHSLK 180

  Fly   206 ELQKKANVFIERNFTQVCQEEEFLQLSAYQLIALIRRDELNVQEEREVYNAVLKWVKYDEDNRHC 270
            :|..:...|...||.:|.|.|||..|...:|...:..|||::..|..|:.||::||.:..:.|..
Zfish   181 QLASRCRTFALLNFPEVAQHEEFQDLRKDELEEYLASDELSICREEVVFEAVMRWVYHGVEYRRP 245

  Fly   271 KMEHILGAVRCQFLTPNFLKEQMKNCDVLRKVPACREYLAKIFKDLTLHKCPGVKERTPNT---- 331
            .::.:|..||...|.||:..:.::...:::..|.|.:.|.:..:...|    |.:..:|.|    
Zfish   246 MLKDLLQHVRLPLLHPNYFVQTVEGDKLIQNAPECYQLLHEARRYHVL----GNEMMSPRTRPRR 306

  Fly   332 ----TRMIFVAGGFFR---HSLDILEAYNVDDMTWTTLANLRIPRSGLGAAFLKGKFYAVGGRNN 389
                :.:|.|.||..|   .:|...|.|:.....||:||  :.|.      :.|.: |||....|
Zfish   307 STGFSEVIVVVGGCERMGGFNLPYTECYDPVTGEWTSLA--KHPE------YTKSE-YAVCALRN 362

  Fly   390 NI---GSSYDSDWVDRYSAVTETWRPCAPMSVPRHRVGVAVMDELMYAVGGSAGMEYHNTVEYYD 451
            :|   |...:|.:|..|::....|...|.::..|.|..:.|:...:|||||..|..|.|.||.||
Zfish   363 DIILSGGRINSSYVWMYNSQLNVWIRVASLNKGRWRHKMTVLLGKVYAVGGYDGQCYLNNVEVYD 427

  Fly   452 PDLDRWTLVQPMHAKRLGVGVVVVNRLLYAIGGF-DGNERLASVECYHPENNEWSFLPPLQTGRS 515
            ...:|||.|.|:........|......|:.|||. |.|.....|:||.||::.|.....|...:.
Zfish   428 SFSNRWTEVAPLKEAVCSPAVTSCAGKLFVIGGEPDENSCSNKVQCYDPESDSWQLKACLPFTKP 492

  Fly   516 GAGVAAINQYIYVVGGFDGTRQLATVERYDTENDTWDMVAPIQIARSALSLTPLDEKLYAIGGFD 580
            .....::|..|||.||.     ..::..||...|.|..|......:.:..::..:.|:|.:||..
Zfish   493 NISAVSLNHLIYVCGGL-----TKSIYCYDPSQDHWMHVGHTFSRQESCGVSVCNGKIYILGGRG 552

  Fly   581 GNNFLS-IVEVYDPRTNTWTTGTPLKSGRSGHASAVIYQ 618
            .|...| .|..|||.:...|:...:....|.|....:::
Zfish   553 ENGEASNNVVCYDPSSGIITSTAAMPRPVSYHGCVTVHR 591

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Keap1NP_732202.2 PHA03098 92..599 CDD:222983 160/522 (31%)
KELCH repeat 369..416 CDD:276965 12/49 (24%)
KELCH repeat 420..463 CDD:276965 19/42 (45%)
KELCH repeat 467..510 CDD:276965 13/43 (30%)
KELCH repeat 514..558 CDD:276965 11/43 (26%)
KELCH repeat 561..606 CDD:276965 11/45 (24%)
klhl24aNP_001070808.1 BTB_POZ_KLHL24_KRIP6 51..167 CDD:349562 44/115 (38%)
PHA03098 67..550 CDD:222983 152/500 (30%)
Kelch 1. /evidence=ECO:0000255 313..362 17/57 (30%)
KELCH repeat 353..392 CDD:276965 11/39 (28%)
Kelch 2. /evidence=ECO:0000255 364..406 10/41 (24%)
KELCH repeat 396..440 CDD:276965 20/43 (47%)
Kelch 3. /evidence=ECO:0000255 407..453 18/45 (40%)
KELCH repeat 443..488 CDD:276965 13/44 (30%)
Kelch 4. /evidence=ECO:0000255 455..501 13/45 (29%)
KELCH repeat 491..527 CDD:276965 10/40 (25%)
Kelch 5. /evidence=ECO:0000255 503..543 10/44 (23%)
KELCH repeat 535..577 CDD:276965 11/41 (27%)
Kelch 544..590 CDD:128874 13/45 (29%)
Kelch 6. /evidence=ECO:0000255 545..591 12/45 (27%)

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