DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Keap1 and Klhl5

DIOPT Version :9

Sequence 1:NP_732202.2 Gene:Keap1 / 42062 FlyBaseID:FBgn0038475 Length:776 Species:Drosophila melanogaster
Sequence 2:NP_780383.2 Gene:Klhl5 / 71778 MGIID:1919028 Length:708 Species:Mus musculus


Alignment Length:619 Identity:219/619 - (35%)
Similarity:328/619 - (52%) Gaps:41/619 - (6%)


- Green bases have known domain annotations that are detailed below.


  Fly    27 RPEEAEMSNTSESCSISCGGRFGSAHSTLDDHDATD---DDMTFCMSNYAKEALKMMYMMRSHGM 88
            |||..:.::..|:.|.|...|..::..||....|.:   .|..|...|:|::..|.|.....|..
Mouse   107 RPEVDDGTSEEENESDSSSSRTSNSSQTLSSCQAMEPCSSDEFFQALNHAEQTFKKMENYLRHKQ 171

  Fly    89 LTDVVLEVKKELFPAHKVVLSAASPYFKAMFTGGLKESEMSRVQLQGVCPTAMSRILYFMYTGQI 153
            |.||:|.......|||::|||:.|.||.||||..::|:....::::||.|.::..::.:.|||::
Mouse   172 LCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRL 236

  Fly   154 RVTEVTVCQLLPAATMFQVPNVIDACCAFLERQLDPTNAIGIAHFAEQHGCVELQKKANVFIERN 218
            .:.|..:..||..|.:.|:..|::|||.||.:||.|:|.:||..||:..||.:|.|.|:.:...:
Mouse   237 ELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEH 301

  Fly   219 FTQVCQEEEFLQLSAYQLIALIRRDELNVQEEREVYNAVLKWVKYDEDNRHCKMEHILGAVRCQF 283
            |.:|.:.:||:.|.|.::..|:..|::|:..|..:.||:|.||::|.:.|...:..:|..:|...
Mouse   302 FMEVIRNQEFVLLPANEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDLSRLLAYIRLPL 366

  Fly   284 LTPNFLKEQMKNCDVLRKVPACREYLAKIFKDLTLHKCPGVKERTP-----------NTTRMIFV 337
            |.|.||.: |:|..:.|....|::.:.:..|   .|..|   ||.|           :|...:|.
Mouse   367 LAPQFLAD-MENNALFRDDIECQKLIMEAMK---YHLLP---ERRPMLQSPRTKPRKSTVGTLFA 424

  Fly   338 AGGF-FRHSLDILEAYNVDDMTWTTLANLRIPRSGLGAAFLKGKFYAVGGRNNNIGSSYDSDWVD 401
            .||. .......:|.|::....||.:||:...|...|.|.|..|.|.||||:    .....:.|:
Mouse   425 VGGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRD----GLKTLNTVE 485

  Fly   402 RYSAVTETWRPCAPMSVPRHRVGVAVMDELMYAVGGSAGMEYHNTVEYYDPDLDRWTLVQPMHAK 466
            .|:..|:||....|||..||.:||||::..||||||..|..|.||||.:||...:|..|..|...
Mouse   486 CYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQWNFVATMSTP 550

  Fly   467 RLGVGVVVVNRLLYAIGGFDGNERLASVECYHPENNEWSFLPPLQTGRSGAGVAAINQYIYVVGG 531
            |..|||.|::..|||:||.||:..|.||||:.|..|:|:....:...|.|.||...|..:|.:||
Mouse   551 RSTVGVAVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGG 615

  Fly   532 FDG-----TRQLA-TVERYDTENDTWDMVAPIQIARSALSLTPLDEKLYAIGGFDGNNFLSIVEV 590
            .|.     |.:|: .|||||.:.|.|..||.:.::|.|:.:..|.:||||:||:||..:|:|||.
Mouse   616 HDAPTSNLTSRLSDCVERYDPKTDVWTAVASMSVSRDAVGVCLLGDKLYAVGGYDGQTYLNIVEA 680

  Fly   591 YDPRTNTWTTGTPLKSGRSGHASAVIYQPACSTT 624
            |||:||.||...||..||:|         ||..|
Mouse   681 YDPQTNEWTQVAPLCLGRAG---------ACVVT 705

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Keap1NP_732202.2 BTB 80..183 CDD:279045 35/102 (34%)
PHA03098 92..599 CDD:222983 190/524 (36%)
BACK 192..294 CDD:285009 32/101 (32%)
Kelch 335..379 CDD:128874 13/44 (30%)
KELCH repeat 369..416 CDD:276965 15/46 (33%)
Kelch 382..430 CDD:128874 19/47 (40%)
KELCH repeat 420..463 CDD:276965 22/42 (52%)
Kelch 433..476 CDD:128874 21/42 (50%)
KELCH repeat 467..510 CDD:276965 20/42 (48%)
Kelch 478..523 CDD:128874 19/44 (43%)
KELCH repeat 514..558 CDD:276965 20/49 (41%)
Kelch_1 514..556 CDD:279660 19/47 (40%)
KELCH repeat 561..606 CDD:276965 24/44 (55%)
Kelch 572..616 CDD:128874 24/43 (56%)
Klhl5NP_780383.2 BTB 163..266 CDD:279045 35/102 (34%)
PHA03098 173..695 CDD:222983 194/532 (36%)
BACK 275..374 CDD:285009 32/98 (33%)
Kelch 422..467 CDD:128874 13/44 (30%)
Kelch_1 456..501 CDD:279660 16/48 (33%)
KELCH repeat 457..500 CDD:276965 15/46 (33%)
KELCH repeat 504..548 CDD:276965 22/43 (51%)
Kelch 517..561 CDD:128874 21/43 (49%)
KELCH repeat 551..594 CDD:276965 20/42 (48%)
Kelch 562..608 CDD:128874 19/45 (42%)
Kelch_1 597..648 CDD:279660 20/50 (40%)
KELCH repeat 598..648 CDD:276965 20/49 (41%)
Kelch_1 651..694 CDD:279660 22/42 (52%)
KELCH repeat 651..694 CDD:276965 22/42 (52%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4441
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D312716at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X9
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
43.820

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