Protein Alignment Keap1 and Klhl10

DIOPT Version :10

• Sequence 1: NP_732202.2
• Gene: Keap1 / 42062
• FlyBaseID: FBgn0038475
• Length: 776
• Species: Drosophila melanogaster
• Sequence 2: NP_080003.1
• Gene: Klhl10 / 66720
• MGIID: 2181067
• Length: 608
• Species: Mus musculus
• Alignment Length: 550
• Identity: 186/550 - (33%)
• Similarity: 290/550 - (52%)
• Gaps: 25/550 - (4%)

  Fly    83 MRSHGMLTDVVLEVKKELFPAHKVVLSAASPYFKAMFTGGLKESEMSRVQLQGVCPTAMSRILYF 147
            :|..|.|.|||::|....|.|||.:|.:.|.||:|:||.|...:|.....:.|:.|..|..|:.:
Mouse    32 LRLEGKLCDVVIKVNGFEFNAHKNILCSCSSYFRALFTSGWNNTEKKVYNIPGISPDMMKLIIEY 96

  Fly   148 MYTGQIRVTEVTVCQLLPAATMFQVPNVIDACCAFLERQLDPTNAIGIAHFAEQHGCVELQKKAN 212
            .||..:.:|...|.:||.||..|.:..::..||.||:.:|...|.|||..|.:.:.|.||::||.
Mouse    97 AYTRTVPITPDNVEKLLAAADQFNIMGIVRGCCEFLKSELCLDNCIGICKFTDYYYCPELRQKAY 161

  Fly   213 VFIERNFTQVCQ-EEEFLQLSAYQLIALIRRDELNVQEEREVYNAVLKWVKYDEDNRHCKMEHIL 276
            :||..||.::.: ..|||:||..:|..:|.:|||||::|..|:.|:|||:.:|..||...:..:|
Mouse   162 MFILHNFEEMVKVSAEFLELSVTELKDIIEKDELNVKQEDAVFEAILKWISHDPQNRKQHISVLL 226

  Fly   277 GAVRCQFLTPNFLKEQMKNCDVLRKVPACREYLAKIFK---DLTLHKCPGVKERTPNTTR----- 333
            ..||...:...:....:|..|.::....|:..:....|   ||.::. |...:.|...||
Mouse   227 PKVRLALMHAEYFMNNVKMNDYVKDSEECKPVIINALKAMYDLNMNG-PSNSDFTNPLTRPRLPY 290

  Fly   334 -MIFVAGGFFRHS-LDILEAYNVDDMTWTTL-ANLRIPRSGLGAAFLKGKFYAVGGRNNNIGSSY 395
             ::|..||:...| .:.:|||:.....|..: .....||:..|||:|||..|.:||        :
Mouse   291 AILFAIGGWSGGSPTNAIEAYDARADRWVNVTCEEESPRAYHGAAYLKGYVYIIGG--------F 347

  Fly   396 DS-DW---VDRYSAVTETWRPCAPMSVPRHRVGVAVMDELMYAVGGSAGMEYHNTVEYYDPDLDR 456
            || |:   |.|:..|.:||...|||...|..|.|.|:...:||:||..|....||.|.|:|:.::
Mouse   348 DSVDYFNSVKRFDPVKKTWHQVAPMHSRRCYVSVTVLSNFIYAMGGFDGYVRLNTAERYEPETNQ 412

  Fly   457 WTLVQPMHAKRLGVGVVVVNRLLYAIGGFDGNERLASVECYHPENNEWSFLPPLQTGRSGAGVAA 521
            |||:.|||.:|.......:...:|..|||:|||.|.:.|.|:.|:|:|:.:.|:::.|||.||.|
Mouse   413 WTLIAPMHEQRSDASATTLYGKVYICGGFNGNECLFTAEVYNTESNQWTVIAPMRSRRSGIGVIA 477

  Fly   522 INQYIYVVGGFDGTRQLATVERYDTENDTWDMVAPIQIARSALSLTPLDEKLYAIGGFDGNNFLS 586
            ..:::|.||||||..:|.:.|.|....:||..:..:...||...:..:|:.|:.:|||:|.....
Mouse   478 YGEHVYAVGGFDGANRLRSAEAYSPVANTWRTIPTMFNPRSNFGIEVVDDLLFVVGGFNGFTTTF 542

  Fly   587 IVEVYDPRTNTWTTGTPLKSGRSGHASAVI 616
            .||.||.:|:.|.....:...||..:..|:
Mouse   543 NVECYDEKTDEWYDAHDMSIYRSALSCCVV 572

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Keap1	NP_732202.2	PHA03098	92..599	CDD:222983	178/522 (34%)
		KELCH repeat	369..416	CDD:276965	19/50 (38%)
		KELCH repeat	420..463	CDD:276965	17/42 (40%)
		KELCH repeat	467..510	CDD:276965	14/42 (33%)
		KELCH repeat	514..558	CDD:276965	18/43 (42%)
		KELCH repeat	561..606	CDD:276965	14/44 (32%)
Klhl10	NP_080003.1	PHA03098	36..572	CDD:222983	184/544 (34%)
		Kelch 1	292..339		14/46 (30%)
		KELCH repeat	329..372	CDD:276965	19/50 (38%)
		Kelch 2	340..386		18/53 (34%)
		KELCH repeat	376..420	CDD:276965	18/43 (42%)
		Kelch 3	388..433		17/44 (39%)
		KELCH repeat	423..466	CDD:276965	14/42 (33%)
		Kelch 4	434..480		20/45 (44%)
		KELCH repeat	470..513	CDD:276965	18/42 (43%)
		Kelch 5	481..527		14/45 (31%)
		KELCH repeat	517..560	CDD:276965	14/42 (33%)
		Kelch 6	529..574		14/43 (33%)