Protein Alignment Keap1 and Klhl28

DIOPT Version :10

• Sequence 1: NP_732202.2
• Gene: Keap1 / 42062
• FlyBaseID: FBgn0038475
• Length: 776
• Species: Drosophila melanogaster
• Sequence 2: NP_079983.1
• Gene: Klhl28 / 66689
• MGIID: 1913939
• Length: 571
• Species: Mus musculus
• Alignment Length: 579
• Identity: 200/579 - (34%)
• Similarity: 292/579 - (50%)
• Gaps: 75/579 - (12%)

  Fly    57 DHDATDDDMTFCMSN----YAKEALKMMYMMRSHGMLTDVVLEVKKELFPAHKVVLSAASPYFKA 117
            ||.|.    |:.::|    ::::.|:.:.::|.|..|.|::|.|......||||||::.||||||
Mouse     2 DHTAP----TYMLANLTHLHSEQLLQGLNLLRQHHELCDIILRVGDVKIHAHKVVLASISPYFKA 62

  Fly   118 MFTGGLKESEMSRVQLQGVCPTAMSRILYFMYTGQIRVTEVTVCQLLPAATMFQVPNVIDACCAF 182
            ||||.|.|.|.|.|:.|.:...|:..|:.:.|||.:.:::.||..|||||.:.|:..|:..||||
Mouse    63 MFTGNLSEKENSEVEFQCIDEAALQAIVEYAYTGTVFISQDTVESLLPAANLLQIKLVLKECCAF 127

  Fly   183 LERQLDPTNAIGIAHFAEQHGCVELQKKANVFIERNFTQVCQEEEFLQLSAYQLIALIRRDELNV 247
            ||.||||.|.|||:.|||.:||.:|...|..||.:||..|||.|||.:|:...|..::..|.|||
Mouse   128 LESQLDPGNCIGISRFAETYGCHDLYLAATKFICQNFESVCQTEEFFELTHADLDEIVSNDCLNV 192

  Fly   248 QEEREVYNAVLKWVKYDEDNRHCKMEHILGAVRCQFLTPNFLKEQMKNCDVLRKVPACREYLAKI 312
            ..|..|:.|:..|:|||...|...:..:|.:||...|:..||....:...::|....|:..|.:.
Mouse   193 ATEETVFYALESWIKYDVQERQKYLAQLLNSVRLPLLSVKFLTRLYEANHLIRDDRTCKHLLNEA 257

  Fly   313 FKD--------------LTLHKC------------------PGVKERTPNT-------------- 331
            .|.              :|..:|                  ..|:...|..
Mouse   258 LKYHFMPEHRLSHQTVLMTRPRCAPKVLCAVGGKSGLFACLDSVEMYFPQNDSWIGLAPLNIPRY 322

  Fly   332 -------TRMIFVAGGF---------FRHSLDILEAYNVDDMTWTTLANLRIPRSGLGAAFLKGK 380
                   .:.:||.||.         .|...:.:|.:|.|..|||:|..:...||.||.|.|.|:
Mouse   323 EFGICVLDQKVFVIGGIETSVRPGMTVRKHENSVECWNPDTNTWTSLERMNESRSTLGVAVLAGE 387

  Fly   381 FYAVGGRNNNIGSSYDSDWVDRYSAVTETWRPCAPMSVPRHRVGVAVMDELMYAVGGSAGMEYHN 445
            .:|:||.:   |.||... |::|......|:|.|||:..|.....||:|.::||:|| .|..:.|
Mouse   388 VFALGGYD---GQSYLQS-VEKYIPKIRQWQPVAPMTTTRSCFAAAVLDGMLYAIGG-YGPAHMN 447

  Fly   446 TVEYYDPDLDRWTLVQPMHAKRLGVGVVVVNRLLYAIGGFDGNERLASVECYHPENNEWSFLPPL 510
            :||.|||..|.|.:|.||..||:..||.|:...::.:||.:|...|:|:|.|.|..|:|:...|:
Mouse   448 SVERYDPSKDSWEMVAPMADKRIHFGVGVMLGFIFVVGGHNGVSHLSSIERYDPHQNQWTVCRPM 512

  Fly   511 QTGRSGAGVAAINQYIYVVGGFDGTRQLATVERYDTENDTWDMVAPIQIARSALSLTPL 569
            :..|:|.|.|.|:.|:|||||..|:..|.||::||..:|||...|.:...|....||.|
Mouse   513 KEPRTGVGAAVIDNYLYVVGGHSGSSYLNTVQKYDPISDTWLDSAGMIYCRCNFGLTAL 571

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Keap1	NP_732202.2	PHA03098	92..599	CDD:222983	190/540 (35%)
		KELCH repeat	369..416	CDD:276965	18/46 (39%)
		KELCH repeat	420..463	CDD:276965	18/42 (43%)
		KELCH repeat	467..510	CDD:276965	14/42 (33%)
		KELCH repeat	514..558	CDD:276965	21/43 (49%)
		KELCH repeat	561..606	CDD:276965	4/9 (44%)
Klhl28	NP_079983.1	PHA03098	35..553	CDD:222983	184/522 (35%)
		Kelch 1	284..331		2/46 (4%)
		KELCH repeat	321..372	CDD:276965	12/50 (24%)
		Kelch 2	332..386		18/53 (34%)
		KELCH repeat	376..419	CDD:276965	18/46 (39%)
		Kelch 3	387..433		16/49 (33%)
		KELCH repeat	423..465	CDD:276965	18/42 (43%)
		Kelch 4	435..479		21/44 (48%)
		KELCH repeat	469..513	CDD:276965	15/43 (35%)
		Kelch 5	480..526		16/45 (36%)
		KELCH repeat	516..559	CDD:276965	21/42 (50%)
		Kelch 6	528..570		17/41 (41%)