Protein Alignment Keap1 and KLHL25

DIOPT Version :10

• Sequence 1: NP_732202.2
• Gene: Keap1 / 42062
• FlyBaseID: FBgn0038475
• Length: 776
• Species: Drosophila melanogaster
• Sequence 2: XP_054234589.1
• Gene: KLHL25 / 64410
• HGNCID: 25732
• Length: 619
• Species: Homo sapiens
• Alignment Length: 577
• Identity: 168/577 - (29%)
• Similarity: 257/577 - (44%)
• Gaps: 43/577 - (7%)

  Fly    50 SAHSTLDDHDATDD-DMT-FCMSNYAKEALKMMYMMRSHGMLTDVVLEVKKELFPAHKVVLSAAS 112
            |.|.|.....:|.. ::| |..:::....|..:..:|.|.|.|||.|......||.|:.||:|:|
Human    34 SVHETRKSRSSTGSMNVTLFHKASHPDCVLAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASS 98

  Fly   113 PYFKAMFTGGLKESEMSRVQLQ-GVCPTAMSRILYFMYTGQIRVTEVTVCQLLPAATMFQVPNVI 176
            .||:|||:.||:||....|..| .:.|..:..:|.|.|:.:|.:.|.....||.|..|.|..:|.
Human    99 RYFEAMFSHGLRESRDDTVNFQDNLHPEVLELLLDFAYSSRIAINEENAESLLEAGDMLQFHDVR 163

  Fly   177 DACCAFLERQLDPTNAIGIAHFAEQHGCVELQKKANVFIERNFTQVCQEEEFLQLSAYQLIALIR 241
            ||...|||:.|.|:|.:|:...::.|.|..|.:.:......:|..|.|.|:|..||...|:.||.
Human   164 DAAAEFLEKNLFPSNCLGMMLLSDAHQCRRLYEFSWRMCLVHFETVRQSEDFNSLSKDTLLDLIS 228

  Fly   242 RDELNVQEEREVYNAVLKWVKYDEDNRHCKMEHILGAVRCQFLTPNFLKEQMKNCDVLRKVPACR 306
            .|||..::||.|:.|:|:|||:|.:.|...:..:|.:||...|..:.|:|.:.:..:|     ..
Human   229 SDELETEDERVVFEAILQWVKHDLEPRKVHLPELLRSVRLALLPSDCLQEAVSSEALL-----MA 288

  Fly   307 EYLAKIFKDLTLHKC-------------PGVKERTPNTTRMIFVAGGFFRHSLDILEAYNVDDMT 358
            :...|:..|..| :|             |..:.|....|.:|.....|....:     |.||...
Human   289 DERTKLIMDEAL-RCKTRILQNDGVVTSPCARPRKAGHTLLILGGQTFMCDKI-----YQVDHKA 347

  Fly   359 WTTL--ANLRIPRSGLGAAFLKGKFYAVGGRNNNIGSSYDSDWVDRYSAVTETWRPCAPMSVPRH 421
            ...:  |:|..||....|:.:..|.|..|||.:..|.|.|. ||  |..|.|.|...|||.:.|.
Human   348 KEIIPKADLPSPRKEFSASAIGCKVYVTGGRGSENGVSKDV-WV--YDTVHEEWSKAAPMLIARF 409

  Fly   422 RVGVAVMDELMYAVGGSAGME---------YHNTVEYYDPDLDRWTLVQPMHAKRLGVGVVVVNR 477
            ..|.|.::..:|.|||...:.         ....||.|||..::|.:|.|:........||....
Human   410 GHGSAELENCLYVVGGHTSLAGVFPASPSVSLKQVEKYDPGANKWMMVAPLRDGVSNAAVVSAKL 474

  Fly   478 LLYAIGGFD-GNERLASVECYHPENNEWSFLPPLQTGRSGAGVAAINQYIYVVGGFDGTRQLATV 541
            .|:..||.. ..:.::.|:||.|..|.|:..............|.:...|:::|| |.....|:.
Human   475 KLFVFGGTSIHRDMVSKVQCYDPSENRWTIKAECPQPWRYTAAAVLGSQIFIMGG-DTEFTAASA 538

  Fly   542 ERYDTENDTWDMVAPIQIARSALSLTPLDEKLYAIGGFDGNNFLSIVEVYDPRTNTW 598
            .|:|.|.:.|..:..:...|.:........|||.:||:.|......::.|||.::||
Human   539 YRFDCETNQWTRIGDMTAKRMSCHALASGNKLYVVGGYFGTQRCKTLDCYDPTSDTW 595

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Keap1	NP_732202.2	PHA03098	92..599	CDD:222983	156/533 (29%)
		KELCH repeat	369..416	CDD:276965	17/46 (37%)
		KELCH repeat	420..463	CDD:276965	14/51 (27%)
		KELCH repeat	467..510	CDD:276965	11/43 (26%)
		KELCH repeat	514..558	CDD:276965	10/43 (23%)
		KELCH repeat	561..606	CDD:276965	12/38 (32%)
KLHL25	XP_054234589.1	BTB_POZ_KLHL25	54..181	CDD:349563	46/126 (37%)
		PHA03098	69..596	CDD:222983	161/542 (30%)
		BACK_KLHL25_ENC2	174..272	CDD:350589	33/97 (34%)
		KELCH repeat	360..404	CDD:276965	17/46 (37%)
		KELCH repeat	408..461	CDD:276965	15/52 (29%)
		KELCH repeat	464..510	CDD:276965	11/45 (24%)
		KELCH repeat	512..554	CDD:276965	10/42 (24%)