DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Keap1 and KLHL12

DIOPT Version :9

Sequence 1:	NP_732202.2	Gene:	Keap1 / 42062	FlyBaseID:	FBgn0038475	Length:	776	Species:	Drosophila melanogaster
Sequence 2:	XP_011508137.1	Gene:	KLHL12 / 59349	HGNCID:	19360	Length:	623	Species:	Homo sapiens

Alignment Length:	578	Identity:	210/578 - (36%)
Similarity:	314/578 - (54%)	Gaps:	35/578 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 SAHSTLDDHDATDDDMTFCMSNYAKEALKMMYMMRSHGMLTDVVLEVKKELFPAHKVVLSAASPY 114
            |.|..:....|..|.||   :.:||..|..|..:|....|.||.|.|:::.||||::||:|.|.|
Human    51 SPHCFMGGIMAPKDIMT---NTHAKSILNSMNSLRKSNTLCDVTLRVEQKDFPAHRIVLAACSDY 112

  Fly   115 FKAMFTGGLKESEMSRVQLQGVCPTAMSRILYFMYTGQIRVTEVTVCQLLPAATMFQVPNVIDAC 179
            |.||||..|.|.....|.:||:..:.|..:|.|:||..:.||...|.:|||||.:.|:..|..||
Human   113 FCAMFTSELSEKGKPYVDIQGLTASTMEILLDFVYTETVHVTVENVQELLPAACLLQLKGVKQAC 177

  Fly   180 CAFLERQLDPTNAIGIAHFAEQHGCVELQKKANVFIERNFTQVCQEEEFLQLSAYQLIALIRRDE 244
            |.|||.||||:|.:||..|||.|.||:|.:.|.||.:::|.:|.|.|||:.||..::..||:.||
Human   178 CEFLESQLDPSNCLGIRDFAETHNCVDLMQAAEVFSQKHFPEVVQHEEFILLSQGEVEKLIKCDE 242

  Fly   245 LNVQEEREVYNAVLKWVKYDEDNRHCKMEHILGAVRCQFLTPNFLKEQMKNCDVLRKVPACREYL 309
            :.|..|..|:.||:.|||:.:..|...:.::|..||...|||.::.:.:.....:|....||:.:
Human   243 IQVDSEEPVFEAVINWVKHAKKEREESLPNLLQYVRMPLLTPRYITDVIDAEPFIRCSLQCRDLV 307

  Fly   310 --AKIFKDLTLHKCPGVKERT--PNT------TRMIFVAGGF--FRHSLDILEAYNVDDMTWTTL 362
              ||.|     |..|.::.:.  |.|      ..::.|.|||  .:..:|::|.|:.....|:.|
Human   308 DEAKKF-----HLRPELRSQMQGPRTRARLGANEVLLVVGGFGSQQSPIDVVEKYDPKTQEWSFL 367

  Fly   363 ANLRIPRSGLGAAFLKGKFYAVGGRNNNIGSSYDS-------DWVDRYSAVTETWRPCAPMSVPR 420
            .::...|..:.:..|..:.|.:||        ||.       :.:|..:.....|...|||:|.|
Human   368 PSITRKRRYVASVSLHDRIYVIGG--------YDGRSRLSSVECLDYTADEDGVWYSVAPMNVRR 424

  Fly   421 HRVGVAVMDELMYAVGGSAGMEYHNTVEYYDPDLDRWTLVQPMHAKRLGVGVVVVNRLLYAIGGF 485
            ...|...:.:::|..||..|...|.::|.|||::|:|:::..|...|.|.|:||.:.::|.:||:
Human   425 GLAGATTLGDMIYVSGGFDGSRRHTSMERYDPNIDQWSMLGDMQTAREGAGLVVASGVIYCLGGY 489

  Fly   486 DGNERLASVECYHPENNEWSFLPPLQTGRSGAGVAAINQYIYVVGGFDGTRQLATVERYDTENDT 550
            ||...|.|||.|.|....|:.:.|:.|.|||||||.:|.:||||||||||..|::||.|:...|:
Human   490 DGLNILNSVEKYDPHTGHWTNVTPMATKRSGAGVALLNDHIYVVGGFDGTAHLSSVEAYNIRTDS 554

  Fly   551 WDMVAPIQIARSALSLTPLDEKLYAIGGFDGNNFLSIVEVYDPRTNTWTTGTPLKSGR 608
            |..|..:...|..:..|.|..:||||.|:|||:.||.:|.|||..::|...|.:.:.|
Human   555 WTTVTSMTTPRCYVGATVLRGRLYAIAGYDGNSLLSSIECYDPIIDSWEVVTSMGTQR 612

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Keap1	NP_732202.2	BTB	80..183	CDD:279045	44/102 (43%)
		PHA03098	92..599	CDD:222983	194/525 (37%)
		BACK	192..294	CDD:285009	39/101 (39%)
		Kelch	335..379	CDD:128874	11/45 (24%)
		KELCH repeat	369..416	CDD:276965	10/53 (19%)
		Kelch	382..430	CDD:128874	13/54 (24%)
		KELCH repeat	420..463	CDD:276965	13/42 (31%)
		Kelch	433..476	CDD:128874	17/42 (40%)
		KELCH repeat	467..510	CDD:276965	17/42 (40%)
		Kelch	478..523	CDD:128874	21/44 (48%)
		KELCH repeat	514..558	CDD:276965	25/43 (58%)
		Kelch_1	514..556	CDD:279660	25/41 (61%)
		KELCH repeat	561..606	CDD:276965	19/44 (43%)
		Kelch	572..616	CDD:128874	17/37 (46%)
KLHL12	XP_011508137.1	BTB	78..181	CDD:279045	44/102 (43%)
		PHA03098	101..556	CDD:222983	170/467 (36%)
		BACK	190..291	CDD:285009	39/100 (39%)
		KELCH repeat	329..370	CDD:276965	9/40 (23%)
		Kelch	337..384	CDD:128874	11/46 (24%)
		KELCH repeat	374..420	CDD:276965	10/53 (19%)
		Kelch	385..434	CDD:128874	13/56 (23%)
		KELCH repeat	424..467	CDD:276965	13/42 (31%)
		Kelch	436..481	CDD:128874	17/44 (39%)
		KELCH repeat	471..514	CDD:276965	17/42 (40%)
		Kelch	482..528	CDD:128874	21/45 (47%)
		KELCH repeat	518..562	CDD:276965	25/43 (58%)
		Kelch	529..575	CDD:128874	20/45 (44%)
		KELCH repeat	565..610	CDD:276965	19/44 (43%)
		Kelch	576..620	CDD:128874	17/37 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4441
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D312716at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820