DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Keap1 and KLHL8

DIOPT Version :9

Sequence 1:	NP_732202.2	Gene:	Keap1 / 42062	FlyBaseID:	FBgn0038475	Length:	776	Species:	Drosophila melanogaster
Sequence 2:	NP_001278932.1	Gene:	KLHL8 / 57563	HGNCID:	18644	Length:	620	Species:	Homo sapiens

Alignment Length:	610	Identity:	188/610 - (30%)
Similarity:	317/610 - (51%)	Gaps:	46/610 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 STLDDHDATDDDMTFCMSNYAKEALKMMY--MMR--SHGMLTDVVLEVKKELFPAHKVVLSAASP 113
            |::.|.|. :|...|    .|.||.|..:  ::|  .:|.|.||.|:|..:|...||:||:...|
Human    31 SSISDGDG-EDSFIF----EANEAWKDFHGSLLRFYENGELCDVTLKVGSKLISCHKLVLACVIP 90

  Fly   114 YFKAMFTGGLKESEMSRVQLQGVCPTAMSRILYFMYTGQIRVTEVTVCQLLPAATMFQVPNVIDA 178
            ||:|||...:.|::.:.::::.....|:..::.|:|:.::.:|...|..||.||.:.||..|..|
Human    91 YFRAMFLSEMAEAKQTLIEIRDFDGDAIEDLVKFVYSSRLTLTVDNVQPLLYAACILQVELVARA 155

  Fly   179 CCAFLERQLDPTNAIGIAHFAEQHGCVELQKKANVFIERNFTQVCQEEEFLQLSAYQLIALIRRD 243
            ||.:::....|:|.:.:..|||.|..::|...|:.:...:||:|.:.|:|:.:|...|..|:...
Human   156 CCEYMKLHFHPSNCLAVRAFAESHNRIDLMDMADQYACDHFTEVVECEDFVSVSPQHLHKLLSSS 220

  Fly   244 ELNVQEEREVYNAVLKWVKYDEDNRHCKMEHILGAVRCQFLTPNFLKEQMKNCDVLRKVPACREY 308
            :||::.|::||||.:||:..:..:....::..|..||...|..:||...:....::::...||:.
Human   221 DLNIENEKQVYNAAIKWLLANPQHHSKWLDETLAQVRLPLLPVDFLMGVVAKEQIVKQNLKCRDL 285

  Fly   309 LAKIFKDLTLH----KCPGVK---ERTP--NTTRMIFVAGGF------FRHSLDILEAYNVDDMT 358
            |.:. ::..||    ..|..:   ..||  :|..::|..||.      ||.    :|.|:::..:
Human   286 LDEA-RNYHLHLSSRAVPDFEYSIRTTPRKHTAGVLFCVGGRGGSGDPFRS----IECYSINKNS 345

  Fly   359 WTTLANLRIPRSGLGAAFLKGKFYAVGGR--NNNIGSSYDSDWVDRYSAVTETWRPCAPMSVPRH 421
            |.....:...|..:|...::||.|||||.  |.::||      ::.:..:|..|...|.|:..|.
Human   346 WFFGPEMNSRRRHVGVISVEGKVYAVGGHDGNEHLGS------MEMFDPLTNKWMMKASMNTKRR 404

  Fly   422 RVGVAVMDELMYAVGGSAGMEYHNTVEYYDPDLDRWTLVQPMHAKRLGVGVVVVNRLLYAIGGFD 486
            .:.:|.:...:||:||.......|.||.||.:.|:|:.|.||:..|.|||.|.:...:||:||.|
Human   405 GIALASLGGPIYAIGGLDDNTCFNDVERYDIESDQWSTVAPMNTPRGGVGSVALVNHVYAVGGND 469

  Fly   487 GNERLASVECYHPENNEWSFLPPLQTGRSGAGVAAINQYIYVVGGFDGTRQLATVERYDTENDTW 551
            |...|:|||.|.|..::|..:..:...|:|.||:.::..:|||||||....|::|||||..::.|
Human   470 GMASLSSVERYDPHLDKWIEVKEMGQRRAGNGVSKLHGCLYVVGGFDDNSPLSSVERYDPRSNKW 534

  Fly   552 DMVAPIQIARSALSLTPLDEKLYAIGGFDGNNFLSIVEVYDPRTNTWTTGTPLKSGRSGHASAVI 616
            |.||.:...|..:.:..:..|::|:||.:||.:|:.||.:||..|.|.....:...|:|...||.
Human   535 DYVAALTTPRGGVGIATVMGKIFAVGGHNGNAYLNTVEAFDPVLNRWELVGSVSHCRAGAGVAVC 599

  Fly   617 YQPACSTTFMDYEDSDAPHPDGSNN 641
               :|.|:    :..|..|  ||||
Human   600 ---SCLTS----QIRDVGH--GSNN 615

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Keap1	NP_732202.2	BTB	80..183	CDD:279045	34/106 (32%)
		PHA03098	92..599	CDD:222983	162/523 (31%)
		BACK	192..294	CDD:285009	29/101 (29%)
		Kelch	335..379	CDD:128874	10/49 (20%)
		KELCH repeat	369..416	CDD:276965	15/48 (31%)
		Kelch	382..430	CDD:128874	14/49 (29%)
		KELCH repeat	420..463	CDD:276965	14/42 (33%)
		Kelch	433..476	CDD:128874	19/42 (45%)
		KELCH repeat	467..510	CDD:276965	18/42 (43%)
		Kelch	478..523	CDD:128874	17/44 (39%)
		KELCH repeat	514..558	CDD:276965	21/43 (49%)
		Kelch_1	514..556	CDD:279660	20/41 (49%)
		KELCH repeat	561..606	CDD:276965	14/44 (32%)
		Kelch	572..616	CDD:128874	16/43 (37%)
KLHL8	NP_001278932.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..35		1/3 (33%)
		BTB	57..161	CDD:279045	34/103 (33%)
		PHA03098	60..535	CDD:222983	148/485 (31%)
		BACK	169..271	CDD:285009	29/101 (29%)
		Kelch	319..366	CDD:128874	10/50 (20%)
		Kelch 1	319..366		10/50 (20%)
		KELCH repeat	356..399	CDD:276965	15/48 (31%)
		Kelch	367..413	CDD:128874	15/51 (29%)
		Kelch 2	367..413		15/51 (29%)
		KELCH repeat	403..447	CDD:276965	15/43 (35%)
		Kelch 3	415..460		19/44 (43%)
		Kelch	415..458	CDD:128874	19/42 (45%)
		KELCH repeat	450..495	CDD:276965	18/44 (41%)
		Kelch	461..502	CDD:128874	15/40 (38%)
		Kelch 4	462..507		17/44 (39%)
		KELCH repeat	497..542	CDD:276965	21/44 (48%)
		Kelch	508..554	CDD:128874	18/45 (40%)
		Kelch 5	508..554		18/45 (40%)
		KELCH repeat	544..586	CDD:276965	14/41 (34%)
		Kelch	555..599	CDD:128874	16/43 (37%)
		Kelch 6	556..601		16/47 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4441
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D312716at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820