DRSC/TRiP Functional Genomics Resources

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Protein Alignment Keap1 and klhl8

DIOPT Version :10

Sequence 1:NP_732202.2 Gene:Keap1 / 42062 FlyBaseID:FBgn0038475 Length:776 Species:Drosophila melanogaster
Sequence 2:NP_001103950.1 Gene:klhl8 / 572347 ZFINID:ZDB-GENE-070209-226 Length:604 Species:Danio rerio


Alignment Length:609 Identity:185/609 - (30%)
Similarity:305/609 - (50%) Gaps:59/609 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly    62 DDDMTFCMSNYAKEA-------LKMMYMMRSHGMLTDVVLEVKKELFPAHKVVLSAASPYFKAMF 119
            |.|.:|...  |:||       |:..|   .:|.|.||.|:|...|.|.||:||:...|||:|||
Zfish    21 DADGSFVFE--AQEAWKDFHNSLRQFY---ENGELCDVTLKVGNRLIPCHKLVLACVVPYFRAMF 80

  Fly   120 TGGLKESEMSRVQLQGVCPTAMSRILYFMYTGQIRVTEVTVCQLLPAATMFQVPNVIDACCAFLE 184
            ...:.|::...::::.....|:..::.|.|:.::.:|...|..||.||.:.||..:..|||.:::
Zfish    81 LSDMAEAKQDLIEIRDFDADAIQDLVRFAYSSRLTLTVDNVQPLLYAACILQVELIARACCEYMK 145

  Fly   185 RQLDPTNAIGIAHFAEQHGCVELQKKANVFIERNFTQVCQEEEFLQLSAYQLIALIRRDELNVQE 249
            ....|:|.:.:..|||.|..|:|...|:.:...:|:||.:.|:|:.:|...|..|:...:||:|.
Zfish   146 AHFHPSNCLAVRTFAESHNRVDLMDMADRYACEHFSQVVECEDFVCVSPQHLKTLLASSDLNIQA 210

  Fly   250 EREVYNAVLKWVKYDEDNRHCKMEHILGAVR-----CQFLTPNFLKEQMKNCDVLRKVPACREYL 309
            |.:||||.:||::.::.:....::.|:..||     .:|||....||:|     ::...:||:.|
Zfish   211 ETQVYNAAVKWLRANQKHHAVWLDQIMAQVRLPLLPVEFLTATVAKEEM-----IKASLSCRDLL 270

  Fly   310 AKIFKDLTLH----KCPGVKERTPNTTR-----MIFVAGGF------FRHSLDILEAYNVDDMTW 359
            .:. ::..||    ..|..:.....|.|     ::|..||.      ||.    :|.|::...:|
Zfish   271 DEA-RNYHLHLSNKSVPDFQYSVRTTARKHTAGVLFCVGGRGGSGDPFRS----IECYSISKNSW 330

  Fly   360 TTLANLRIPRSGLGAAFLKGKFYAVGGR--NNNIGSSYDSDWVDRYSAVTETWRPCAPMSVPRHR 422
            .....:...|..:|...:.||.|||||.  |.::||      ::.:...|..|...|.|:..|..
Zfish   331 FFGPEMNSRRRHVGVISVAGKVYAVGGHDGNEHLGS------MEMFDPHTNKWMMRASMNTKRRG 389

  Fly   423 VGVAVMDELMYAVGGSAGMEYHNTVEYYDPDLDRWTLVQPMHAKRLGVGVVVVNRLLYAIGGFDG 487
            :.:|.:...:||:||.......:.||.||.:.|||:.|..|:..|.|||.|.:...:||:||.||
Zfish   390 IALAALGGPLYAIGGLDDNSCFSDVERYDIECDRWSAVAAMNTPRGGVGSVALGGFVYAVGGNDG 454

  Fly   488 NERLASVECYHPENNEWSFLPPLQTGRSGAGVAAINQYIYVVGGFDGTRQLATVERYDTENDTWD 552
            ...|:|||.:.|..|:|:.:..:...|:|.||:.::..:|||||||....|::|||:|...:.||
Zfish   455 VASLSSVERFDPHLNKWTEVREMGQRRAGNGVSELHGCLYVVGGFDDNSPLSSVERFDPRLNRWD 519

  Fly   553 MVAPIQIARSALSLTPLDEKLYAIGGFDGNNFLSIVEVYDPRTNTWTTGTPLKSGRSGHASAVIY 617
            .|..:...|..:.:..:..:::|:||.:||.:|:.||.::||.|.|.....:...|:|...||  
Zfish   520 YVCELTTPRGGVGVATVMGRVFAVGGHNGNIYLNTVEAFEPRMNRWELVGSVSHCRAGAGVAV-- 582

  Fly   618 QPACSTTFMDYEDSDAPHPDGSNN 641
               |||......|..    .||:|
Zfish   583 ---CSTLISQVRDVG----QGSSN 599

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Keap1NP_732202.2 PHA03098 92..599 CDD:222983 162/528 (31%)
KELCH repeat 369..416 CDD:276965 15/48 (31%)
KELCH repeat 420..463 CDD:276965 14/42 (33%)
KELCH repeat 467..510 CDD:276965 18/42 (43%)
KELCH repeat 514..558 CDD:276965 19/43 (44%)
KELCH repeat 561..606 CDD:276965 13/44 (30%)
klhl8NP_001103950.1 BTB_POZ_KLHL8 36..155 CDD:349547 37/121 (31%)
PHA03098 44..526 CDD:222983 154/500 (31%)
KELCH repeat 340..383 CDD:276965 15/48 (31%)
KELCH repeat 387..431 CDD:276965 14/43 (33%)
KELCH repeat 434..479 CDD:276965 18/44 (41%)
KELCH repeat 481..525 CDD:276965 19/43 (44%)
KELCH repeat 528..570 CDD:276965 13/41 (32%)
Kelch 539..583 CDD:128874 16/48 (33%)

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