Protein Alignment Keap1 and klhl3

DIOPT Version :10

• Sequence 1: NP_732202.2
• Gene: Keap1 / 42062
• FlyBaseID: FBgn0038475
• Length: 776
• Species: Drosophila melanogaster
• Sequence 2: XP_009289334.1
• Gene: klhl3 / 568556
• ZFINID: ZDB-GENE-120203-4
• Length: 593
• Species: Danio rerio
• Alignment Length: 588
• Identity: 203/588 - (34%)
• Similarity: 326/588 - (55%)
• Gaps: 27/588 - (4%)

  Fly    54 TLDDH-DATDDDMTFCMSNYAKEALKMMYMMRSHGMLTDVVLEVKKELFPAHKVVLSAASPYFKA 117
            :||.. ||.|..:......:.::|..:|..:||..||.||:|...:...|||:|||::.||||.|
Zfish    14 SLDSQDDAKDPGLHTFSHTHMRKAFLLMNDLRSRKMLCDVLLVAGEVEIPAHRVVLASCSPYFCA 78

  Fly   118 MFTGGLKESEMSRVQLQGVCPTAMSRILYFMYTGQIRVTEVTVCQLLPAATMFQVPNVIDACCAF 182
            ||||.:.||:.:.|:::.|....:.:::.::|:.:|.|:|..|..|||||::.|:.:|...||.|
Zfish    79 MFTGDMSESKANHVEIRDVDGQTLLKLVDYIYSAEIEVSEENVQVLLPAASLLQLMDVRQVCCDF 143

  Fly   183 LERQLDPTNAIGIAHFAEQHGCVELQKKANVFIERNFTQVCQEEEFLQLSAYQLIALIRRDELNV 247
            |:.||.|||.:||..||:.|.|..|..:|:.:.|::||.|...|||:.||..|:.:||..|:|.|
Zfish   144 LQTQLHPTNCLGIRAFADLHACTVLLSQAHAYAEQHFTDVMVGEEFMALSLQQVCSLISSDKLTV 208

  Fly   248 QEEREVYNAVLKWVKYDEDNRHCKMEHILGAVRCQFLTPNFLKEQMKNCDVLRKVPACREYLAKI 312
            ..|.:|:.|::.|:|:|::.|...|..::..||...|:.::|.:.::...:::....|:::|.:.
Zfish   209 STEEKVFEAMVAWIKHDKEARLEHMPKLMEHVRLPLLSRDYLVQIVEEEPLIKNNNTCKDFLIEA 273

  Fly   313 FKDLTLHKCPG----------VKERTP-NTTRMIFVAGGFFRHSLDILEAYNVDDMTWTTLANLR 366
            .|   .|..|.          .:.||| :..:::.|.||....::..:|.|:..:..|..:|:|.
Zfish   274 MK---YHLLPADQRHLIKTDRTRPRTPISLPKVMMVVGGQAPKAIRSVECYDFQEDRWYQVADLP 335

  Fly   367 IPRSGLGAAFLKGKFYAVGGRNNNIGSSYDSDWVDRYSAVTETWRPCAPMSVPRHRVGVAVMDEL 431
            ..|...|..::.||.|||||.|.::...    .||.|..:.:.|.....|...|..:|.||:.:|
Zfish   336 SRRCRAGVVYMAGKVYAVGGFNGSLRVR----TVDVYDGLKDQWSSIPSMQERRSTLGAAVLGDL 396

  Fly   432 MYAVGGSAGMEYHNTVEYYDPDLDRWTLVQPMHAKRLGVGVVVVNRLLYAIGGFDGNER--LASV 494
            :|||||..|....::||.|:|..:.|..|.||:.:|..|||.||:..|||:||:||..|  |::|
Zfish   397 LYAVGGFDGSTGLSSVEAYNPKANEWMFVAPMNTRRSSVGVGVVDGKLYAVGGYDGASRQCLSTV 461

  Fly   495 ECYHPENNEWSFLPPLQTGRSGAGVAAINQYIYVVGGFDGTRQLATVERYDTENDTWDMVAPIQI 559
            |.::|.:|:|.::..:.|.||||||..::..:|..||.||.....:||.||...:||..|..:.:
Zfish   462 EEFNPVSNKWCYVSDMSTRRSGAGVGVLSGQLYAAGGHDGPLVRKSVEVYDPTTNTWRQVCDMNM 526

  Fly   560 ARSALSLTPLDEKLYAIGGFDGNNFLSIVEVYDPRTNTWT-TGTPLKSGRSGHA----SAVIYQP 619
            .|....:..::..||.|||.||:..||.||.|||..:.|: ..|.:.:||| :|    |..:|.|
Zfish   527 CRRNAGVCAINGLLYVIGGDDGSCNLSSVEYYDPAADKWSLIPTNMSNGRS-YAGLFPSHNLYAP 590

  Fly   620 ACS 622
            ..|
Zfish   591 PIS 593

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Keap1	NP_732202.2	PHA03098	92..599	CDD:222983	181/519 (35%)
		KELCH repeat	369..416	CDD:276965	14/46 (30%)
		KELCH repeat	420..463	CDD:276965	17/42 (40%)
		KELCH repeat	467..510	CDD:276965	20/44 (45%)
		KELCH repeat	514..558	CDD:276965	18/43 (42%)
		KELCH repeat	561..606	CDD:276965	17/45 (38%)
klhl3	XP_009289334.1	BTB_POZ_KLHL2-like	31..150	CDD:349544	46/118 (39%)
		PHA03098	51..567	CDD:222983	183/522 (35%)
		BACK_KLHL3	148..277	CDD:350588	42/131 (32%)
		KELCH repeat	338..381	CDD:276965	14/46 (30%)
		KELCH repeat	385..428	CDD:276965	17/42 (40%)
		KELCH repeat	432..478	CDD:276965	20/45 (44%)
		KELCH repeat	481..526	CDD:276965	18/44 (41%)
		KELCH repeat	528..569	CDD:276965	16/40 (40%)