DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Keap1 and KLHL4

DIOPT Version :9

Sequence 1:	NP_732202.2	Gene:	Keap1 / 42062	FlyBaseID:	FBgn0038475	Length:	776	Species:	Drosophila melanogaster
Sequence 2:	NP_476503.1	Gene:	KLHL4 / 56062	HGNCID:	6355	Length:	720	Species:	Homo sapiens

Alignment Length:	621	Identity:	210/621 - (33%)
Similarity:	328/621 - (52%)	Gaps:	41/621 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 QMHSPMQYETHISDMPNHKGYP--------C--RPEEAEM---SNTSESCSISCGGRFGSAHSTL 55
            |.|:.:.:.....|.|  |..|        |  |.::.||   .|..:|.:     |..:.||
Human    92 QQHNLIVHFQANEDTP--KSVPEKNLFKEACEKRAQDLEMMADDNIEDSTA-----RLDTQHS-- 147

  Fly    56 DDHDATDDDMTFCMSNYAKEALKMMYMMRSHGMLTDVVLEVKKELFPAHKVVLSAASPYFKAMFT 120
            :|.:||..:..|.:.|:|::.|:.|........|.||:|.......|||::||||.|.||.||||
Human   148 EDMNATRSEEQFHVINHAEQTLRKMENYLKEKQLCDVLLIAGHLRIPAHRLVLSAVSDYFAAMFT 212

  Fly   121 GGLKESEMSRVQLQGVCPTAMSRILYFMYTGQIRVTEVTVCQLLPAATMFQVPNVIDACCAFLER 185
            ..:.|::...|:::||.|.|::.::.:.|||.:::.|.|:..||.||.:.|:..|||.|..||.:
Human   213 NDVLEAKQEEVRMEGVDPNALNSLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIK 277

  Fly   186 QLDPTNAIGIAHFAEQHGCVELQKKANVFIERNFTQVCQEEEFLQLSAYQLIALIRRDELNVQEE 250
            ||.|:|.:||..|.:..||.||...|:.:...:|.:|.:.:|||.|.|.::..|:..|::||.:|
Human   278 QLHPSNCLGIRSFGDAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDINVPDE 342

  Fly   251 REVYNAVLKWVKYDEDNRHCKMEHILGAVRCQFLTPNFLKEQMKNCDVLRKVPACREYLAKIFK- 314
            ..:::|:::||.:|..||..::..:|..:|...|.|..|.: ::...:......|::.|.:..|
Human   343 ETIFHALMQWVGHDVQNRQGELGMLLSYIRLPLLPPQLLAD-LETSSMFTGDLECQKLLMEAMKY 406

  Fly   315 -----DLTLHKCPGVKERTPNTTRMIFVAGGF-FRHSLDILEAYNVDDMTWTTLANLRIPRSGLG 373
                 ..::.:.|..|.| .:|...::..||. .......:|.|::...:|..:..:...|...|
Human   407 HLLPERRSMMQSPRTKPR-KSTVGALYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMNGRRLQFG 470

  Fly   374 AAFLKGKFYAVGGRNNNIGSSYDSDWVDRYSAVTETWRPCAPMSVPRHRVGVAVMDELMYAVGGS 438
            .|.:..|.|.||||:    .....:.|:.::.|.:.|....|||..||.:|||.::..||||||.
Human   471 VAVIDNKLYVVGGRD----GLKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVGGH 531

  Fly   439 AGMEYHNTVEYYDPDLDRWTLVQPMHAKRLGVGVVVVNRLLYAIGGFDGNERLASVECYHPENNE 503
            .|..|.||||.:||:..:|..|..|...|..||||.:|..||||||.||:..|.|:|.:.|..|:
Human   532 DGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDGSSCLKSMEYFDPHTNK 596

  Fly   504 WSFLPPLQTGRSGAGVAAINQYIYVVGGFDG------TRQLATVERYDTENDTWDMVAPIQIARS 562
            ||...|:...|.|.|||..|.::|||||.|.      :|....|||||.:.|:|..|||:.:.|.
Human   597 WSLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNHCSRLSDCVERYDPKGDSWSTVAPLSVPRD 661

  Fly   563 ALSLTPLDEKLYAIGGFDGNNFLSIVEVYDPRTNTW 598
            |:::.||.:|||.:||:||:.:|:.||.||.:.|.|
Human   662 AVAVCPLGDKLYVVGGYDGHTYLNTVESYDAQRNEW 697

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Keap1	NP_732202.2	BTB	80..183	CDD:279045	39/102 (38%)
		PHA03098	92..599	CDD:222983	185/520 (36%)
		BACK	192..294	CDD:285009	31/101 (31%)
		Kelch	335..379	CDD:128874	8/44 (18%)
		KELCH repeat	369..416	CDD:276965	12/46 (26%)
		Kelch	382..430	CDD:128874	16/47 (34%)
		KELCH repeat	420..463	CDD:276965	21/42 (50%)
		Kelch	433..476	CDD:128874	21/42 (50%)
		KELCH repeat	467..510	CDD:276965	21/42 (50%)
		Kelch	478..523	CDD:128874	21/44 (48%)
		KELCH repeat	514..558	CDD:276965	23/49 (47%)
		Kelch_1	514..556	CDD:279660	21/47 (45%)
		KELCH repeat	561..606	CDD:276965	18/38 (47%)
		Kelch	572..616	CDD:128874	14/27 (52%)
KLHL4	NP_476503.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	46..69
		BTB	172..276	CDD:279045	40/103 (39%)
		PHA03098	176..698	CDD:222983	187/528 (35%)
		BACK	284..373	CDD:285009	27/88 (31%)
		Kelch 1	430..476		8/45 (18%)
		Kelch	431..476	CDD:128874	8/44 (18%)
		Kelch_1	465..510	CDD:279660	13/48 (27%)
		KELCH repeat	466..509	CDD:276965	12/46 (26%)
		Kelch 2	477..523		17/49 (35%)
		KELCH repeat	513..557	CDD:276965	21/43 (49%)
		Kelch 3	525..570		22/44 (50%)
		Kelch	526..570	CDD:128874	21/43 (49%)
		KELCH repeat	560..603	CDD:276965	21/42 (50%)
		Kelch	571..617	CDD:128874	21/45 (47%)
		Kelch 4	571..617		21/45 (47%)
		KELCH repeat	607..658	CDD:276965	23/50 (46%)
		Kelch	619..670	CDD:128874	21/50 (42%)
		Kelch 5	619..670		21/50 (42%)
		Kelch_1	659..702	CDD:279660	18/39 (46%)
		KELCH repeat	660..699	CDD:276965	18/38 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4441
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D312716at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820