Protein Alignment Keap1 and klhl10b.2

DIOPT Version :10

• Sequence 1: NP_732202.2
• Gene: Keap1 / 42062
• FlyBaseID: FBgn0038475
• Length: 776
• Species: Drosophila melanogaster
• Sequence 2: XP_073784245.1
• Gene: klhl10b.2 / 560458
• ZFINID: ZDB-GENE-131127-61
• Length: 581
• Species: Danio rerio
• Alignment Length: 568
• Identity: 176/568 - (30%)
• Similarity: 288/568 - (50%)
• Gaps: 34/568 - (5%)

  Fly    69 MSNY-AKEALKMMYMMRSHGMLTDVVLEVKKELFPAHKVVLSAASPYFKAMFTGGLKESEMSRVQ 132
            |.|: :..||.:....|..|..||:::......|..||:::.|.||||:.:|:.....:......
Zfish     1 MENFNSPTALNVFDEARLLGEHTDLIIRANGTEFQVHKIIMCACSPYFRVLFSSKWTSTAEHTYD 65

  Fly   133 LQGVCPTAMSRILYFMYTGQIRVTEVTVCQLLPAATMFQVPNVIDACCAFLERQLDPTNAIGIAH 197
            :..:.|..:..|:.:.||....:|...|.:||..|....:..::.|||.||:..|.|.|.|||..
Zfish    66 IPEMSPDILYLIIQYAYTRSALITAENVLKLLVTADQLLISGLVAACCQFLDTHLGPENCIGIHM 130

  Fly   198 FAEQ-HGCVELQKKANVFIERNFTQVCQ-EEEFLQLSAYQLIALIRRDELNVQEEREVYNAVLKW 260
            ..:. |.|.:|..||..||.::|..|.| .||||:|...:|..:|..::|||:.|..|:.|:|.|
Zfish   131 ITKDFHSCSKLHHKAKRFILQHFENVLQVSEEFLELPLEELEEIIDDNKLNVRHEEVVFEAILHW 195

  Fly   261 VKYDEDNRHCKMEHILGAVRCQFLTPNFLKEQMKNCDVLRKVPACREYLAKIFKDL--------- 316
            :.::.::|...:..:|..||...:|..:..:.:|:..::.:..||:..:....|.|
Zfish   196 IDHEPESRRKHIATLLPKVRLGLMTLQYFMDNVKHNPLVMENEACKPVILSAMKALFDFQFDGPI 260

  Fly   317 ---TLHKCPGVKERTPNTTRMIFVAGGFFRHSLDILEAYNVDDMTWTTLANLRIPRSG--LGAAF 376
               .||:.  .:.|.|:.  ::...||:.....:.:||:::....|..: |....||.  ||.|.
Zfish   261 SSELLHRL--TRPRLPSA--ILLAIGGWSNGPTNEIEAFDMRAEQWVNV-NEVDERSTAYLGTAV 320

  Fly   377 LKGKFYAVGGRNNNIGSSYDS----DWVDRYSAVTETWRPCAPMSVPRHRVGVAVMDELMYAVGG 437
            |:...|.:||        |||    :.|.:::.:|:||...|||...|..|.|||:|.|:||:||
Zfish   321 LEEFVYCIGG--------YDSVEYFNNVRKFNLITQTWHEVAPMYERRCYVSVAVLDGLIYAIGG 377

  Fly   438 SAGMEYHNTVEYYDPDLDRWTLVQPMHAKRLGVGVVVVNRLLYAIGGFDGNERLASVECYHPENN 502
            ..|:|..|:.|.|:||.::|||...|:.:|.......:...:|..|||.|.|.|.|.||::|:.|
Zfish   378 FDGLERLNSAECYNPDTNQWTLTAQMNERRSDASASSLQGKVYICGGFTGTECLFSAECFNPQTN 442

  Fly   503 EWSFLPPLQTGRSGAGVAAINQYIYVVGGFDGTRQLATVERYDTENDTWDMVAPIQIARSALSLT 567
            :|:.:.|:::.|||.||.|.:..:|.||||||..:|.|.|.|:...:.|..||.:...||...:.
Zfish   443 QWTLIAPMRSRRSGLGVIAYDGLVYAVGGFDGASRLRTAEAYNPLTNIWRDVASMHKTRSNFGIE 507

  Fly   568 PLDEKLYAIGGFDGNNFLSIVEVYDPRTNTWTTGTPLKSGRSGHASAV 615
            .:|::|:|:|||||:..:|.|:.||...:.|.:.......||..:..|
Zfish   508 VVDDQLFAVGGFDGSGTISDVDCYDVEMDEWYSVNKASISRSALSCCV 555

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Keap1	NP_732202.2	PHA03098	92..599	CDD:222983	164/526 (31%)
		KELCH repeat	369..416	CDD:276965	17/52 (33%)
		KELCH repeat	420..463	CDD:276965	21/42 (50%)
		KELCH repeat	467..510	CDD:276965	14/42 (33%)
		KELCH repeat	514..558	CDD:276965	20/43 (47%)
		KELCH repeat	561..606	CDD:276965	15/44 (34%)
klhl10b.2	XP_073784245.1	None