DRSC/TRiP Functional Genomics Resources

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Protein Alignment Keap1 and KLHL7

DIOPT Version :10

Sequence 1:NP_732202.2 Gene:Keap1 / 42062 FlyBaseID:FBgn0038475 Length:776 Species:Drosophila melanogaster
Sequence 2:NP_001026880.2 Gene:KLHL7 / 55975 HGNCID:15646 Length:586 Species:Homo sapiens


Alignment Length:573 Identity:174/573 - (30%)
Similarity:266/573 - (46%) Gaps:74/573 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly    73 AKEALKM-------MYMMRSHGMLTDVVLEVKKELFPAHKVVLSAASPYFKAMFTGGLKESEMSR 130
            |:|..|:       |..||....|.||:|.|::...|||:|||:|||.:|..|||..:.||:...
Human    20 AREEAKLLAGFMGVMNNMRKQKTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFE 84

  Fly   131 VQLQGVCPTAMSRILYFMYTGQIRVTEVTVCQLLPAATMFQVPNVIDACCAFLERQLDPTNAIGI 195
            |:|:...|..:.:::.|.||.:|.|....|..||.||..:|:..|...|..||:.|:|.:|.:||
Human    85 VELKDAEPDIIEQLVEFAYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVDASNCLGI 149

  Fly   196 AHFAEQHGCVELQKKANVFIERNFTQVCQEEEFLQLSAYQLIALIRRDELNVQEEREVYNAVLKW 260
            :..||...|.||:..|:.||.::||:|.:.:|||||...::..|:.:|.|.|:.|.:||:|.::|
Human   150 SVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRW 214

  Fly   261 VKYDEDNRHCKMEHILGAVRCQFLTPNFLKEQMKNCDVLRKVPAC-------------------- 305
            :||||.||...|..||..||...::.|||.:.::...:::..|.|                    
Human   215 LKYDEPNRQPFMVDILAKVRFPLISKNFLSKTVQAEPLIQDNPECLKMVISGMRYHLLSPEDREE 279

  Fly   306 -----------REYLAKIF-------------KDL--TLHKCPGVKERTPNTT---RMIFVAGGF 341
                       .:|...:|             ||.  |..:||..|.|.....   .::::.||.
Human   280 LVDGTRPRRKKHDYRIALFGGSQPQSCRYFNPKDYSWTDIRCPFEKRRDAACVFWDNVVYILGGS 344

  Fly   342 FRHSLDILEAYNVDDMTWTTLANLRIPRSGLGAAFLKGKFYAVGGRNNNIGSS--YDSDWVDRYS 404
            ....:..::.|||...:|.:......||..|.|...:||.|..||  :.:|:|  |   ..:.|.
Human   345 QLFPIKRMDCYNVVKDSWYSKLGPPTPRDSLAACAAEGKIYTSGG--SEVGNSALY---LFECYD 404

  Fly   405 AVTETWRPCAPMSVPRHRVGVAVMDELMYAVGGSAGMEYH----NTVEYYDPDLDRWTLVQPMHA 465
            ..||:|.....|...|...|:...:.|:|..|||.|....    |:.|.|||..:.||.:.||..
Human   405 TRTESWHTKPSMLTQRCSHGMVEANGLIYVCGGSLGNNVSGRVLNSCEVYDPATETWTELCPMIE 469

  Fly   466 KRLGVGVVVVNRLLYAIGGFDGNERLASVECYHPENNEWSFLPPLQTGRSGAGVAAINQYIYVVG 530
            .|...|:|.|...::|:||.:|...|.:||.|..:.|||..:.|:.........||:...:||:.
Human   470 ARKNHGLVFVKDKIFAVGGQNGLGGLDNVEYYDIKLNEWKMVSPMPWKGVTVKCAAVGSIVYVLA 534

  Fly   531 GFDGTRQLATVERYDTENDTWDMVAPIQIARSALSLTPLDEKLYAIGGFDGNN 583
            ||.|..:|..:..|:||.|.|       :|.|.:...|:...|..:....|.|
Human   535 GFQGVGRLGHILEYNTETDKW-------VANSKVRAFPVTSCLICVVDTCGAN 580

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Keap1NP_732202.2 PHA03098 92..599 CDD:222983 166/547 (30%)
KELCH repeat 369..416 CDD:276965 15/48 (31%)
KELCH repeat 420..463 CDD:276965 15/46 (33%)
KELCH repeat 467..510 CDD:276965 15/42 (36%)
KELCH repeat 514..558 CDD:276965 13/43 (30%)
KELCH repeat 561..606 CDD:276965 5/23 (22%)
KLHL7NP_001026880.2 BTB_POZ_KLHL7 23..148 CDD:349546 45/124 (36%)
PHA03098 37..555 CDD:222983 163/522 (31%)
BACK_KLHL7 140..237 CDD:350522 41/96 (43%)
Kelch 1 294..336 8/41 (20%)
Kelch 2 337..382 10/44 (23%)
KELCH repeat 372..416 CDD:276965 15/48 (31%)
Kelch 3 383..430 14/51 (27%)
KELCH repeat 420..468 CDD:276965 16/47 (34%)
Kelch 4 431..481 19/49 (39%)
KELCH repeat 471..515 CDD:276965 16/43 (37%)
Kelch 5 483..528 14/44 (32%)
Kelch 6 530..575 15/51 (29%)

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