Protein Alignment Keap1 and klhl30

DIOPT Version :10

• Sequence 1: NP_732202.2
• Gene: Keap1 / 42062
• FlyBaseID: FBgn0038475
• Length: 776
• Species: Drosophila melanogaster
• Sequence 2: XP_688150.5
• Gene: klhl30 / 559694
• ZFINID: ZDB-GENE-100913-2
• Length: 593
• Species: Danio rerio
• Alignment Length: 624
• Identity: 173/624 - (27%)
• Similarity: 274/624 - (43%)
• Gaps: 87/624 - (13%)

  Fly    63 DDMTFCMSNYAKEALKMMYMMRSHGMLTDVVLEVKKELFPAHKVVLSAASPYFKAMFTGGLKESE 127
            ||:.||:|::....|:.:..:.|.....||.|......||.|:.:|:..|.||.:||:|...||.
Zfish     6 DDLDFCLSSHPGSILEGLRSLCSQPKFVDVTLSAGGRDFPCHRGILALCSHYFHSMFSGDFIESI 70

  Fly   128 MSRVQLQGVCPTAMSRILYFMYTGQIRVTEVTVCQLLPAATMFQVPNVIDACCAFLERQLDPTNA 192
            .:||:|..|.|..:|.:|.|.|||::.:.:..|..|:..::..|...|...||.:|:.|:|.||.
Zfish    71 AARVELHDVDPDVLSSLLDFAYTGKLTINKNNVEGLICTSSQLQFHTVRSVCCRYLQHQIDATNC 135

  Fly   193 IGIAHFAEQHGCVELQKKANVFIERNFTQVCQEEEFLQLSAYQLIALIRRDELNVQEEREVYNAV 257
            :||..|.|.|||.|:..||..|:..||..|.|.||||||...:|:|.::.::|:::::|....||
Zfish   136 LGILEFGEIHGCPEVVAKAWSFLLENFEAVKQHEEFLQLEKDRLVACLKDEDLHLRDDRSCAEAV 200

  Fly   258 LKWVKYDEDNRHCKMEHILGAVRCQFLTPNFLKEQMKNCDVLRKVPACREYLAKIFKDLTLHKCP 322
            :.||::.:|:|.|.:..:|...:...|:.::|.|.:....:::.....||.:.:|.::.......
Zfish   201 VSWVRHSKDSRICDLRELLSLAKLSLLSESYLTENLLKEPLVQNSLESRELVERICREKRQLTGD 265

  Fly   323 GVKERTP-----NTTRMIFVAGGFFRHSLDIL------EAYNVDDMTWTTLANLRIPRSGLGAAF 376
            |..|:..     |...::||.||   .|||..      |..|.|............|:  ||..|
Zfish   266 GKTEQRATQDAFNQQEVLFVMGG---RSLDDSDDEDEDEDENRDGRLHPRNCGFYNPK--LGQWF 325

  Fly   377 LKGKF-------YAVGGRNNNI----GS--SYDSDWVDRYSAVTETWR---------PCAPMSVP 419
            ....|       |:|...|||:    ||  |..:.|     :.||||:         ..|||..|
Zfish   326 QLPDFPNYNKWGYSVISLNNNVYVTGGSRGSQSNTW-----STTETWKYITREGKWVTVAPMLRP 385

  Fly   420 RHRVGVAVMDELMYAVGGSAGMEYHNTVEYYDPDLDRWTLVQPMHAKRLGVGVVVVNRLLYAIGG 484
            |.....|.::..:|.:||:.    .:.||.|||..:.|||..|................||.||.
Zfish   386 RTNHSSATLNGEIYVIGGTT----TDFVERYDPFSNCWTLTSPALKYVTNFTATPCEGKLYLIGS 446

  Fly   485 FDGNERLASVECYHPENNEW-----SFLP-----PLQTGRSGAGVAAINQYIYVVGGFDGTRQLA 539
            ........:::||:|..:.|     .|:|     |......|.        ||::|  |.|::
Zfish   447 CAVKYNALTMQCYNPVIDSWCIIGSPFIPKYLSSPCSVSMDGV--------IYLIG--DNTKK-- 499

  Fly   540 TVERYDTENDTWDMVAPIQIARSALSLTPLDEKLYAIG----GFDGNNFLSIVEVYDPRTNTWTT 600
             |..||.:::.|:.:..:.:......|..|...|:..|    |.:|:..:. ||:|:..:|||..
Zfish   500 -VYSYDPDSNVWEKIQFLNMLHENGDLVVLGRYLFVTGGHWKGMEGDYGVE-VEMYNRASNTWKV 562

  Fly   601 G--TPLKSGRSGHASAVIYQPACSTTFMDYEDSDAPHPD 637
            .  .|.....||          |.:.|:|........||
Zfish   563 ECFLPRLWTYSG----------CCSVFLDTSQWTEIFPD 591

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Keap1	NP_732202.2	PHA03098	92..599	CDD:222983	156/553 (28%)
		KELCH repeat	369..416	CDD:276965	18/68 (26%)
		KELCH repeat	420..463	CDD:276965	13/42 (31%)
		KELCH repeat	467..510	CDD:276965	10/52 (19%)
		KELCH repeat	514..558	CDD:276965	10/43 (23%)
		KELCH repeat	561..606	CDD:276965	13/50 (26%)
klhl30	XP_688150.5	None