Protein Alignment Keap1 and kbtbd12

DIOPT Version :10

• Sequence 1: NP_732202.2
• Gene: Keap1 / 42062
• FlyBaseID: FBgn0038475
• Length: 776
• Species: Drosophila melanogaster
• Sequence 2: NP_001029089.1
• Gene: kbtbd12 / 559380
• ZFINID: ZDB-GENE-050904-1
• Length: 623
• Species: Danio rerio
• Alignment Length: 599
• Identity: 157/599 - (26%)
• Similarity: 263/599 - (43%)
• Gaps: 104/599 - (17%)

  Fly    77 LKMMYMMRSHGMLTDVVLEVKKELFPAHKVVLSAASPYFKAMFTGGLKESEMSRVQLQGVCPTAM 141
            |:.:..||....||||||..:...||.|:.||||.||||:.|||.||:|....:|.|:.:...::
Zfish    12 LEQLNRMRDAEQLTDVVLVAEGVSFPCHRAVLSAFSPYFRVMFTCGLRECSNRQVVLRDMPAPSL 76

  Fly   142 SRILYFMYTGQIRVTEVTVCQLLPAATMFQVPNVIDACCAFLERQLDPTNAIGIAHFAEQHGCVE 206
            :.:|.:||:..:.:|...|..:..||.:.|:.:|...|..::...:|.||.:||.::|...|..|
Zfish    77 ALLLEYMYSSNLPLTADNVQGISVAAFLLQMDDVFSRCQIYMIDNMDTTNCLGIYYYARDLGAEE 141

  Fly   207 LQKKANVFIERNFTQVCQEEEFLQLSAYQLIALIRRDELNVQEEREVYNAVLKWVKY-------D 264
            |..:|..::.::||:||..||.|:|.|:||.||:..|:|||..|..:.:.|::||||       :
Zfish   142 LADQAQRYLRQHFTEVCYGEEVLELEAHQLGALLSSDDLNVSREESILDVVMRWVKYCPGDVGSE 206

  Fly   265 EDNRHCKMEHILGAVRCQFLTPNFLKEQMKNCDVLRKVPACREYLAKIFK--------------- 314
            |:||...:..:|..||...:..::||..||....|.....|.:.:.:..:
Zfish   207 EENRARHLPELLKKVRLPLVGVDYLKGTMKRNTALLVDAECLQIMEEAIEAASLDSDAPPRRLKL 271

  Fly   315 -------DLTL---HKCPGVKER-----------TPNTTRMIFVAGGFFRHSLDILEA------- 351
                   ||.|   ::..|::.|           .|.|.|.:|:....:..:|..:.|
Zfish   272 RYGMETTDLLLCIGNEGGGIRSRYGSYTERSFCYAPTTGRTLFITSPRYGEALGYVFAGVVTEKN 336

  Fly   352 -------------------------YNVDDM-TWTTLANLRIPRSGLGAAFLKGKFYAVGGRNNN 390
                                     ||.:.. :|..|::... |.....:.|....|.:||:...
Zfish   337 EIVVSGELGARKMARHKDKNVEIFMYNKEAQGSWKHLSSAEY-RDSYALSSLGENLYLIGGQMKL 400

  Fly   391 IGSSYDSDWVDRYSAVTETWRPCAPMSVPRHRVGVAVMDELMYAVGGSAGMEYH---------NT 446
            ....:.::.|:|:|.....||..||:.:|.....|..|...:|.:||.....:.         |.
Zfish   401 KNQYHITNSVERWSLQGGPWRSTAPLPMPLAYHSVVRMKGRLYVLGGRTPQSFRTDDEPDRMSNR 465

  Fly   447 VEYYDPDLDRWTLVQPMHAKRLGVGVVVVNRLLYAIGGF--DGNER------LASVECYHPENNE 503
            :..|||:.::|..:.||...:.....|.:|..:|.:||.  :|.:|      |..||.|:|:.:.
Zfish   466 LLEYDPETNKWNELGPMKFSKYRCSAVALNGEIYVLGGIGCEGVDRGQSRYCLNVVEIYNPDGDF 530

  Fly   504 WSFLPP-------LQTGRSGAGVAAINQYIYVVGGFDGTRQLATVERYDTENDTWDMVAPIQIAR 561
            |...||       |::..|.|||  ::..:||.|.:.|..:..|:.:...:.|.|:.|..: :|:
Zfish   531 WRDGPPLPWPLLTLRSNASNAGV--VDGKLYVCGYYKGADRHDTITKDILQLDPWENVWTV-VAK 592

  Fly   562 SALSLTPLDEKLYA 575
            .||.....|..|.|
Zfish   593 QALMHDSYDVCLVA 606

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Keap1	NP_732202.2	PHA03098	92..599	CDD:222983	151/584 (26%)
		KELCH repeat	369..416	CDD:276965	11/46 (24%)
		KELCH repeat	420..463	CDD:276965	10/51 (20%)
		KELCH repeat	467..510	CDD:276965	15/57 (26%)
		KELCH repeat	514..558	CDD:276965	12/43 (28%)
		KELCH repeat	561..606	CDD:276965	5/15 (33%)
kbtbd12	NP_001029089.1	BTB_POZ	4..130	CDD:453885	41/117 (35%)
		PHA03098	27..592	CDD:222983	145/568 (26%)
		BACK_KBTBD12	122..228	CDD:350560	39/105 (37%)
		KELCH repeat	379..426	CDD:276965	11/46 (24%)
		Kelch 1	390..440		13/49 (27%)
		KELCH repeat	430..483	CDD:276965	11/52 (21%)
		Kelch 2	441..496		11/54 (20%)
		KELCH repeat	486..532	CDD:276965	12/45 (27%)
		Kelch 3	498..551		15/52 (29%)
		KELCH repeat	545..591	CDD:276965	12/48 (25%)
		Kelch 4	557..607		14/51 (27%)