DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Keap1 and dbo

DIOPT Version :9

Sequence 1:	NP_732202.2	Gene:	Keap1 / 42062	FlyBaseID:	FBgn0038475	Length:	776	Species:	Drosophila melanogaster
Sequence 2:	NP_524989.2	Gene:	dbo / 53556	FlyBaseID:	FBgn0040230	Length:	623	Species:	Drosophila melanogaster

Alignment Length:	628	Identity:	237/628 - (37%)
Similarity:	340/628 - (54%)	Gaps:	27/628 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 ISDMPNHKGYPCRPEEAEMSNTSESCSISCGGRFGSAHSTLDDHDATDDDMTFCMSNYAKEALKM 79
            :.|:|. .|...:|.:|.::.|..:   |..|...|..||..|...:...::.....:.|..|..
  Fly     1 MGDLPG-SGSTAQPRDAAVTGTGGN---STAGGGSSVGSTAVDRPPSPARLSHTSEKHPKVTLTE 61

  Fly    80 MYMMRSHGMLTDVVLEVKKELFPAHKVVLSAASPYFKAMFTGGLKESEMSRVQLQGVCPTAMSRI 144
            :.|:|.|..|.||||.|......||:|:|||.|.||.|||||.|:||..:.|.::.:...||..:
  Fly    62 LNMLRRHRELCDVVLNVGGRKIFAHRVILSACSSYFCAMFTGELEESRQTEVTIRDIDENAMELL 126

  Fly   145 LYFMYTGQIRVTEVTVCQLLPAATMFQVPNVIDACCAFLERQLDPTNAIGIAHFAEQHGCVELQK 209
            :.|.||..|.|.|..|..|||||.:.|:..:.|.||.||:|||||||.:||..||:.|.|.||.:
  Fly   127 IDFCYTAHIIVEESNVQTLLPAACLLQLVEIQDICCEFLKRQLDPTNCLGIRAFADTHSCRELLR 191

  Fly   210 KANVFIERNFTQVCQEEEFLQLSAYQLIALIRRDELNVQEEREVYNAVLKWVKYDEDNRHCKMEH 274
            .|:.|.:.||.:|.:.||||.|...||:.:|..|||||:.|.:|:|||:.|:||:...|...:..
  Fly   192 IADKFTQHNFQEVMESEEFLLLPVGQLVDIICSDELNVRSEEQVFNAVMSWLKYNVAERRQHLAQ 256

  Fly   275 ILGAVRCQFLTPNFLKEQMKNCDVLRKVPACREYL--AKIF----KDLTLHKCPGVKERTPNTTR 333
            :|..||...|:|.||...:.:..::|...|||:.:  ||.:    ::..|.:.|..:.|.| |.|
  Fly   257 VLQHVRLPLLSPKFLVGTVGSDLLVRSDEACRDLVDEAKNYLLLPQERPLMQGPRTRPRKP-TRR 320

  Fly   334 --MIFVAGGFFR-HSLDILEAYNVDDMTWTTLANLRIPRSGLGAAFLKGKFYAVGGRNNNIGSSY 395
              ::|..||:.. .::..:|.::.....|..:|.:...|.|:|.|.|....|||||.:   |.||
  Fly   321 GEVLFAVGGWCSGDAIASVERFDPQTNDWKMVAPMSKRRCGVGVAVLNDLLYAVGGHD---GQSY 382

  Fly   396 DSDWVDRYSAVTETWRPC--APMSVPRHRVGVAVMDELMYAVGGSAGMEYHNTVEYYDPDLDRWT 458
            .:. ::||...|..| .|  ||.:..|..|||||:|..:|||||..|::..|.||.|||..::|:
  Fly   383 LNS-IERYDPQTNQW-SCDVAPTTSCRTSVGVAVLDGFLYAVGGQDGVQCLNHVERYDPKENKWS 445

  Fly   459 LVQPMHAKRLGVGVVVVNRLLYAIGGFDGNERLASVECYHPENNEWSFLPPLQTGRSGAGVAAIN 523
            .|.||..:||||.|.|:...||||||.||...|.:||.|.|.:|:|..:.|:.|.|...|.|..|
  Fly   446 KVAPMTTRRLGVAVAVLGGFLYAIGGSDGQCPLNTVERYDPRHNKWVAVSPMSTRRKHLGCAVFN 510

  Fly   524 QYIYVVGGFDGTRQLATVERYDTENDTWDMVAPIQIARSALSLTPLDEKLYAIGGFDGNNFLSIV 588
            .|||.|||.|...:|::.|||:...:||..:..:...||.:.|..::.:|||:|||||:.:|..:
  Fly   511 NYIYAVGGRDDCMELSSAERYNPLTNTWSPIVAMTSRRSGVGLAVVNGQLYAVGGFDGSAYLKTI 575

  Fly   589 EVYDPRTNTWTTGTPLKSGRSGHASAVIYQPA------CSTTF 625
            |||||.||.|.....:...|.|....|:..|.      |..:|
  Fly   576 EVYDPETNQWRLCGCMNYRRLGGGVGVMRAPQTENYMWCENSF 618

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Keap1	NP_732202.2	BTB	80..183	CDD:279045	45/102 (44%)
		PHA03098	92..599	CDD:222983	211/517 (41%)
		BACK	192..294	CDD:285009	42/101 (42%)
		Kelch	335..379	CDD:128874	11/44 (25%)
		KELCH repeat	369..416	CDD:276965	19/48 (40%)
		Kelch	382..430	CDD:128874	21/49 (43%)
		KELCH repeat	420..463	CDD:276965	21/42 (50%)
		Kelch	433..476	CDD:128874	22/42 (52%)
		KELCH repeat	467..510	CDD:276965	21/42 (50%)
		Kelch	478..523	CDD:128874	20/44 (45%)
		KELCH repeat	514..558	CDD:276965	17/43 (40%)
		Kelch_1	514..556	CDD:279660	17/41 (41%)
		KELCH repeat	561..606	CDD:276965	20/44 (45%)
		Kelch	572..616	CDD:128874	19/43 (44%)
dbo	NP_524989.2	BTB_POZ_KLHL20_KLEIP	49..176	CDD:349558	56/126 (44%)
		PHA03098	69..587	CDD:222983	214/523 (41%)
		KELCH repeat	359..403	CDD:276965	19/48 (40%)
		KELCH repeat	407..451	CDD:276965	22/43 (51%)
		KELCH repeat	454..497	CDD:276965	21/42 (50%)
		KELCH repeat	501..545	CDD:276965	17/43 (40%)
		KELCH repeat	548..593	CDD:276965	20/44 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45464360
Domainoid	1	1.000	52	1.000	Domainoid score	I4252
eggNOG	1	0.900	-	-		E1_KOG4441
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	57	1.000	Inparanoid score	I2576
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D26788at33392
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm2846
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24412
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X9
	9	8.900