Protein Alignment Keap1 and dbo

DIOPT Version :10

• Sequence 1: NP_732202.2
• Gene: Keap1 / 42062
• FlyBaseID: FBgn0038475
• Length: 776
• Species: Drosophila melanogaster
• Sequence 2: NP_524989.2
• Gene: dbo / 53556
• FlyBaseID: FBgn0040230
• Length: 623
• Species: Drosophila melanogaster
• Alignment Length: 628
• Identity: 237/628 - (37%)
• Similarity: 340/628 - (54%)
• Gaps: 27/628 - (4%)

  Fly    15 ISDMPNHKGYPCRPEEAEMSNTSESCSISCGGRFGSAHSTLDDHDATDDDMTFCMSNYAKEALKM 79
            :.|:|. .|...:|.:|.::.|..:   |..|...|..||..|...:...::.....:.|..|..
  Fly     1 MGDLPG-SGSTAQPRDAAVTGTGGN---STAGGGSSVGSTAVDRPPSPARLSHTSEKHPKVTLTE 61

  Fly    80 MYMMRSHGMLTDVVLEVKKELFPAHKVVLSAASPYFKAMFTGGLKESEMSRVQLQGVCPTAMSRI 144
            :.|:|.|..|.||||.|......||:|:|||.|.||.|||||.|:||..:.|.::.:...||..:
  Fly    62 LNMLRRHRELCDVVLNVGGRKIFAHRVILSACSSYFCAMFTGELEESRQTEVTIRDIDENAMELL 126

  Fly   145 LYFMYTGQIRVTEVTVCQLLPAATMFQVPNVIDACCAFLERQLDPTNAIGIAHFAEQHGCVELQK 209
            :.|.||..|.|.|..|..|||||.:.|:..:.|.||.||:|||||||.:||..||:.|.|.||.:
  Fly   127 IDFCYTAHIIVEESNVQTLLPAACLLQLVEIQDICCEFLKRQLDPTNCLGIRAFADTHSCRELLR 191

  Fly   210 KANVFIERNFTQVCQEEEFLQLSAYQLIALIRRDELNVQEEREVYNAVLKWVKYDEDNRHCKMEH 274
            .|:.|.:.||.:|.:.||||.|...||:.:|..|||||:.|.:|:|||:.|:||:...|...:..
  Fly   192 IADKFTQHNFQEVMESEEFLLLPVGQLVDIICSDELNVRSEEQVFNAVMSWLKYNVAERRQHLAQ 256

  Fly   275 ILGAVRCQFLTPNFLKEQMKNCDVLRKVPACREYL--AKIF----KDLTLHKCPGVKERTPNTTR 333
            :|..||...|:|.||...:.:..::|...|||:.:  ||.:    ::..|.:.|..:.|.| |.|
  Fly   257 VLQHVRLPLLSPKFLVGTVGSDLLVRSDEACRDLVDEAKNYLLLPQERPLMQGPRTRPRKP-TRR 320

  Fly   334 --MIFVAGGFFR-HSLDILEAYNVDDMTWTTLANLRIPRSGLGAAFLKGKFYAVGGRNNNIGSSY 395
              ::|..||:.. .::..:|.::.....|..:|.:...|.|:|.|.|....|||||.:   |.||
  Fly   321 GEVLFAVGGWCSGDAIASVERFDPQTNDWKMVAPMSKRRCGVGVAVLNDLLYAVGGHD---GQSY 382

  Fly   396 DSDWVDRYSAVTETWRPC--APMSVPRHRVGVAVMDELMYAVGGSAGMEYHNTVEYYDPDLDRWT 458
            .:. ::||...|..| .|  ||.:..|..|||||:|..:|||||..|::..|.||.|||..::|:
  Fly   383 LNS-IERYDPQTNQW-SCDVAPTTSCRTSVGVAVLDGFLYAVGGQDGVQCLNHVERYDPKENKWS 445

  Fly   459 LVQPMHAKRLGVGVVVVNRLLYAIGGFDGNERLASVECYHPENNEWSFLPPLQTGRSGAGVAAIN 523
            .|.||..:||||.|.|:...||||||.||...|.:||.|.|.:|:|..:.|:.|.|...|.|..|
  Fly   446 KVAPMTTRRLGVAVAVLGGFLYAIGGSDGQCPLNTVERYDPRHNKWVAVSPMSTRRKHLGCAVFN 510

  Fly   524 QYIYVVGGFDGTRQLATVERYDTENDTWDMVAPIQIARSALSLTPLDEKLYAIGGFDGNNFLSIV 588
            .|||.|||.|...:|::.|||:...:||..:..:...||.:.|..::.:|||:|||||:.:|..:
  Fly   511 NYIYAVGGRDDCMELSSAERYNPLTNTWSPIVAMTSRRSGVGLAVVNGQLYAVGGFDGSAYLKTI 575

  Fly   589 EVYDPRTNTWTTGTPLKSGRSGHASAVIYQPA------CSTTF 625
            |||||.||.|.....:...|.|....|:..|.      |..:|
  Fly   576 EVYDPETNQWRLCGCMNYRRLGGGVGVMRAPQTENYMWCENSF 618

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Keap1	NP_732202.2	PHA03098	92..599	CDD:222983	211/517 (41%)
		KELCH repeat	369..416	CDD:276965	19/48 (40%)
		KELCH repeat	420..463	CDD:276965	21/42 (50%)
		KELCH repeat	467..510	CDD:276965	21/42 (50%)
		KELCH repeat	514..558	CDD:276965	17/43 (40%)
		KELCH repeat	561..606	CDD:276965	20/44 (45%)
dbo	NP_524989.2	BTB_POZ_KLHL20_KLEIP	49..176	CDD:349558	56/126 (44%)
		PHA03098	69..587	CDD:222983	214/523 (41%)
		KELCH repeat	359..403	CDD:276965	19/48 (40%)
		KELCH repeat	407..451	CDD:276965	22/43 (51%)
		KELCH repeat	454..497	CDD:276965	21/42 (50%)
		KELCH repeat	501..545	CDD:276965	17/43 (40%)
		KELCH repeat	548..593	CDD:276965	20/44 (45%)