DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Keap1 and KLHL5

DIOPT Version :9

Sequence 1:NP_732202.2 Gene:Keap1 / 42062 FlyBaseID:FBgn0038475 Length:776 Species:Drosophila melanogaster
Sequence 2:XP_011512001.1 Gene:KLHL5 / 51088 HGNCID:6356 Length:804 Species:Homo sapiens


Alignment Length:597 Identity:213/597 - (35%)
Similarity:319/597 - (53%) Gaps:38/597 - (6%)


- Green bases have known domain annotations that are detailed below.


  Fly    27 RPE------EAEMSNTSESCSISCGGRFGSAHSTLDDHDATDDDMTFCMSNYAKEALKMMYMMRS 85
            |||      |.|..:.|.||..|...:..|:..|::  ..|.|:. |...|:|::..|.|.....
Human   188 RPEVDDGTSEEENESDSSSCRTSNSSQTLSSCHTME--PCTSDEF-FQALNHAEQTFKKMENYLR 249

  Fly    86 HGMLTDVVLEVKKELFPAHKVVLSAASPYFKAMFTGGLKESEMSRVQLQGVCPTAMSRILYFMYT 150
            |..|.||:|.......|||::|||:.|.||.||||..::|:....::::||.|.::..::.:.||
Human   250 HKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYT 314

  Fly   151 GQIRVTEVTVCQLLPAATMFQVPNVIDACCAFLERQLDPTNAIGIAHFAEQHGCVELQKKANVFI 215
            |::.:.|..:..||..|.:.|:..|::|||.||.:||.|:|.:||..||:..||.:|.|.|:.:.
Human   315 GRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYT 379

  Fly   216 ERNFTQVCQEEEFLQLSAYQLIALIRRDELNVQEEREVYNAVLKWVKYDEDNRHCKMEHILGAVR 280
            ..:|.:|.:.:||:.|.|.::..|:..|::|:..|..:.||:|.||::|.:.|...:..:|..:|
Human   380 MEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDLSKLLAYIR 444

  Fly   281 CQFLTPNFLKEQMKNCDVLRKVPACREYLAKIFKDLTLHKCPGVKERTP-----------NTTRM 334
            ...|.|.||.: |:|..:.|....|::.:.:..|   .|..|   ||.|           :|...
Human   445 LPLLAPQFLAD-MENNVLFRDDIECQKLIMEAMK---YHLLP---ERRPMLQSPRTKPRKSTVGT 502

  Fly   335 IFVAGGF-FRHSLDILEAYNVDDMTWTTLANLRIPRSGLGAAFLKGKFYAVGGRNNNIGSSYDSD 398
            :|..||. .......:|.|::....||.:||:...|...|.|.|..|.|.||||:    .....:
Human   503 LFAVGGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRD----GLKTLN 563

  Fly   399 WVDRYSAVTETWRPCAPMSVPRHRVGVAVMDELMYAVGGSAGMEYHNTVEYYDPDLDRWTLVQPM 463
            .|:.|:..|:||....|||..||.:||||::..||||||..|..|.||||.:||...:|..|..|
Human   564 TVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQWNFVATM 628

  Fly   464 HAKRLGVGVVVVNRLLYAIGGFDGNERLASVECYHPENNEWSFLPPLQTGRSGAGVAAINQYIYV 528
            ...|..|||.|::..|||:||.||:..|.||||:.|..|:|:....:...|.|.||...|..:|.
Human   629 STPRSTVGVAVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYA 693

  Fly   529 VGGFDG-----TRQLA-TVERYDTENDTWDMVAPIQIARSALSLTPLDEKLYAIGGFDGNNFLSI 587
            :||.|.     |.:|: .|||||.:.|.|..||.:.|:|.|:.:..|.:||||:||:||..:|:.
Human   694 IGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAYLNT 758

  Fly   588 VEVYDPRTNTWT 599
            ||.|||:||.||
Human   759 VEAYDPQTNEWT 770

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Keap1NP_732202.2 BTB 80..183 CDD:279045 35/102 (34%)
PHA03098 92..599 CDD:222983 190/524 (36%)
BACK 192..294 CDD:285009 32/101 (32%)
Kelch 335..379 CDD:128874 13/44 (30%)
KELCH repeat 369..416 CDD:276965 15/46 (33%)
Kelch 382..430 CDD:128874 19/47 (40%)
KELCH repeat 420..463 CDD:276965 22/42 (52%)
Kelch 433..476 CDD:128874 21/42 (50%)
KELCH repeat 467..510 CDD:276965 20/42 (48%)
Kelch 478..523 CDD:128874 19/44 (43%)
KELCH repeat 514..558 CDD:276965 20/49 (41%)
Kelch_1 514..556 CDD:279660 19/47 (40%)
KELCH repeat 561..606 CDD:276965 21/39 (54%)
Kelch 572..616 CDD:128874 18/28 (64%)
KLHL5XP_011512001.1 BTB 244..347 CDD:279045 35/102 (34%)
PHA03098 254..775 CDD:222983 193/528 (37%)
BACK 356..455 CDD:285009 32/98 (33%)
Kelch 503..548 CDD:128874 13/44 (30%)
Kelch_1 537..582 CDD:279660 16/48 (33%)
KELCH repeat 538..581 CDD:276965 15/46 (33%)
KELCH repeat 585..629 CDD:276965 22/43 (51%)
Kelch 598..642 CDD:128874 21/43 (49%)
KELCH repeat 632..675 CDD:276965 20/42 (48%)
Kelch 643..689 CDD:128874 19/45 (42%)
Kelch_1 678..729 CDD:279660 20/50 (40%)
KELCH repeat 679..729 CDD:276965 20/49 (41%)
Kelch_1 732..772 CDD:279660 21/39 (54%)
KELCH repeat 732..772 CDD:276965 21/39 (54%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4441
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D312716at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X9
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.820

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