DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Keap1 and Keap1

DIOPT Version :9

Sequence 1:	NP_732202.2	Gene:	Keap1 / 42062	FlyBaseID:	FBgn0038475	Length:	776	Species:	Drosophila melanogaster
Sequence 2:	NP_001103775.1	Gene:	Keap1 / 50868	MGIID:	1858732	Length:	624	Species:	Mus musculus

Alignment Length:	629	Identity:	293/629 - (46%)
Similarity:	392/629 - (62%)	Gaps:	35/629 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 MQYETHISDMPNHKGY-----PCRPEEA--EMSNTSESCSISC-----GGRFGSAHSTLDDHDAT 61
            ||.|..:|..|....:     .| ||.|  .:...|..|....     |.|..|  .||:||
Mouse     1 MQPEPKLSGAPRSSQFLPLWSKC-PEGAGDAVMYASTECKAEVTPSQDGNRTFS--YTLEDH--- 59

  Fly    62 DDDMTFCMSNYAKEALKMMYMMRSHGMLTDVVLEVKKELFP-----AHKVVLSAASPYFKAMFTG 121
                       .|:|..:|..:|....|.||.|:||.|..|     ||||||:::||.||||||.
Mouse    60 -----------TKQAFGVMNELRLSQQLCDVTLQVKYEDIPAAQFMAHKVVLASSSPVFKAMFTN 113

  Fly   122 GLKESEMSRVQLQGVCPTAMSRILYFMYTGQIRVTEVTVCQLLPAATMFQVPNVIDACCAFLERQ 186
            ||:|..|..|.::|:.|..|.|::.|.||..|.|.|..|..::..|.|:|:.:|:.||..||.:|
Mouse   114 GLREQGMEVVSIEGIHPKVMERLIEFAYTASISVGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQ 178

  Fly   187 LDPTNAIGIAHFAEQHGCVELQKKANVFIERNFTQVCQEEEFLQLSAYQLIALIRRDELNVQEER 251
            |||:||||||:||||.||.||.::|..:|..:|.:|.::|||..||..||..||.||:|||:.|.
Mouse   179 LDPSNAIGIANFAEQIGCTELHQRAREYIYMHFGEVAKQEEFFNLSHCQLATLISRDDLNVRCES 243

  Fly   252 EVYNAVLKWVKYDEDNRHCKMEHILGAVRCQFLTPNFLKEQMKNCDVLRKVPACREYLAKIFKDL 316
            ||::|.:.|||||...|...::.:|.||||..|||.||:.|::.|::|:....|::||.:||::|
Mouse   244 EVFHACIDWVKYDCPQRRFYVQALLRAVRCHALTPRFLQTQLQKCEILQADARCKDYLVQIFQEL 308

  Fly   317 TLHK-CPGVKERTPNTTRMIFVAGGFFRHSLDILEAYNVDDMTWTTLANLRIPRSGLGAAFLKGK 380
            |||| ...|..|.|...|:|:.|||:||.||..|||||..:.:|..||:|::|||||....:.|.
Mouse   309 TLHKPTQAVPCRAPKVGRLIYTAGGYFRQSLSYLEAYNPSNGSWLRLADLQVPRSGLAGCVVGGL 373

  Fly   381 FYAVGGRNNNIGSSYDSDWVDRYSAVTETWRPCAPMSVPRHRVGVAVMDELMYAVGGSAGMEYHN 445
            .||||||||:...:.||..:|.|:.:|..|.|||.|||||:|:||.|:|..:||||||.|..:|:
Mouse   374 LYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCASMSVPRNRIGVGVIDGHIYAVGGSHGCIHHS 438

  Fly   446 TVEYYDPDLDRWTLVQPMHAKRLGVGVVVVNRLLYAIGGFDGNERLASVECYHPENNEWSFLPPL 510
            :||.|:|:.|.|.||.||..:|:||||.|:||||||:|||||..||.|.|||:||.|||..:.|:
Mouse   439 SVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITPM 503

  Fly   511 QTGRSGAGVAAINQYIYVVGGFDGTRQLATVERYDTENDTWDMVAPIQIARSALSLTPLDEKLYA 575
            .|.||||||..::..||..||:||..||.:|||||.|.:||..|||::..||||.:|....|:|.
Mouse   504 NTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVETETWTFVAPMRHHRSALGITVHQGKIYV 568

  Fly   576 IGGFDGNNFLSIVEVYDPRTNTWTTGTPLKSGRSGHASAVIYQP 619
            :||:||:.||..||.|||.::||:..|.:.|||||...||..:|
Mouse   569 LGGYDGHTFLDSVECYDPDSDTWSEVTRMTSGRSGVGVAVTMEP 612

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Keap1	NP_732202.2	BTB	80..183	CDD:279045	46/107 (43%)
		PHA03098	92..599	CDD:222983	259/512 (51%)
		BACK	192..294	CDD:285009	52/101 (51%)
		Kelch	335..379	CDD:128874	22/43 (51%)
		KELCH repeat	369..416	CDD:276965	22/46 (48%)
		Kelch	382..430	CDD:128874	26/47 (55%)
		KELCH repeat	420..463	CDD:276965	22/42 (52%)
		Kelch	433..476	CDD:128874	24/42 (57%)
		KELCH repeat	467..510	CDD:276965	28/42 (67%)
		Kelch	478..523	CDD:128874	28/44 (64%)
		KELCH repeat	514..558	CDD:276965	25/43 (58%)
		Kelch_1	514..556	CDD:279660	23/41 (56%)
		KELCH repeat	561..606	CDD:276965	21/44 (48%)
		Kelch	572..616	CDD:128874	22/43 (51%)
Keap1	NP_001103775.1	BTB	67..176	CDD:279045	48/113 (42%)
		PHA03098	95..596	CDD:222983	255/501 (51%)
		BACK	184..286	CDD:285009	52/101 (51%)
		Kelch	327..372	CDD:128874	22/44 (50%)
		Kelch 1	327..372		22/44 (50%)
		KELCH repeat	362..409	CDD:276965	21/46 (46%)
		Kelch	373..423	CDD:128874	27/49 (55%)
		Kelch 2	373..423		27/49 (55%)
		KELCH repeat	413..456	CDD:276965	22/42 (52%)
		Kelch 3	424..470		25/45 (56%)
		Kelch	424..469	CDD:128874	24/44 (55%)
		KELCH repeat	460..503	CDD:276965	28/42 (67%)
		Kelch	471..517	CDD:128874	27/45 (60%)
		Kelch 4	471..517		27/45 (60%)
		KELCH repeat	507..551	CDD:276965	24/43 (56%)
		Kelch	518..564	CDD:128874	24/45 (53%)
		Kelch 5	519..564		23/44 (52%)
		KELCH repeat	554..597	CDD:276965	20/42 (48%)
		Kelch	565..611	CDD:128874	22/45 (49%)
		Kelch 6	565..611		22/45 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	101	1.000	Domainoid score	I6943
eggNOG	1	0.900	-	-		E1_KOG4441
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8184
Inparanoid	1	1.050	550	1.000	Inparanoid score	I1131
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46913
OrthoDB	1	1.010	-	-		D312716at33208
OrthoFinder	1	1.000	-	-		FOG0007175
OrthoInspector	1	1.000	-	-		oto94791
orthoMCL	1	0.900	-	-		OOG6_107392
Panther	1	1.100	-	-	LDO	PTHR24412
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5397
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.870