Protein Alignment Keap1 and Kbtbd12

DIOPT Version :10

• Sequence 1: NP_732202.2
• Gene: Keap1 / 42062
• FlyBaseID: FBgn0038475
• Length: 776
• Species: Drosophila melanogaster
• Sequence 2: NP_001418799.1
• Gene: Kbtbd12 / 502859
• RGDID: 1585999
• Length: 627
• Species: Rattus norvegicus
• Alignment Length: 622
• Identity: 163/622 - (26%)
• Similarity: 276/622 - (44%)
• Gaps: 90/622 - (14%)

  Fly    89 LTDVVLEVKKELFPAHKVVLSAASPYFKAMFTGGLKESEMSRVQLQGVCPTAMSRILYFMYTGQI 153
            :.||||..::|.||.|::||:|.|||||||||.||.|.....|.|..:...::|.||.:||:..:
  Rat    30 MVDVVLIAEEEKFPCHRLVLAAFSPYFKAMFTCGLLECTQKEVILYDITAESVSVILNYMYSAVL 94

  Fly   154 RVTEVTVCQLLPAATMFQVPNVIDACCAFLERQLDPTNAIGIAHFAEQHGCVELQKKANVFIERN 218
            .:....|..:..||...|:..|...|..::...:|.:|.|||.:||:|.|..:|..::..::.::
  Rat    95 EINNANVQTVAMAAYFMQMEEVFSVCQNYMMDHMDASNCIGIYYFAKQIGAEDLSDQSKKYLYQH 159

  Fly   219 FTQVCQEEEFLQLSAYQLIALIRRDELNVQEEREVYNAVLKWVKYDEDNRHCKMEHILGAVRCQF 283
            |.:|....|.|.:.|:||:|||:.|:||:..|..:.:.||:||.:::..|...:..:|..||.:.
  Rat   160 FAEVSLHGEILDIEAHQLLALIKSDDLNISREESILDLVLRWVNHNQALRTEHLVELLKQVRLEL 224

  Fly   284 LTPNFLKEQMKNCDVLRKVPACREYLAKIFKDLTLHKCPGVKERTPN------TTRMIFVAGG-- 340
            :..:||::.::...:|....:|.:.:...||.:   |.|  ::.:.|      ||.::...|.
  Rat   225 INASFLRQALRRNTMLLCDGSCIDMIQNAFKAI---KTP--QQHSSNLRYGMETTSLLLCIGNNS 284

  Fly   341 ---FFRHSLDILEAYNVDDMTWTTLANLRIPRSGLG------AAFLKGKFYAVGG---------- 386
               ..||......::..|.::..|.. :..|:.|.|      ...::.....|.|
  Rat   285 SGIRSRHRSYGDASFCYDPVSQKTYF-ISSPKYGEGLGTVCTGVVMENNTIIVAGEATATRLSRQ 348

  Fly   387 RNNNIGSSYDSDWVDRYSAVTETW-RPCAPMSVPRHRVGVAVMDELMYAVGGSAGMEYH----NT 446
            ::.||......|..:|:      | :.|.......:.:|....|  :|.:||...::..    |.
  Rat   349 KSKNIEIYRYHDRGNRF------WEKLCTAEFRELYALGSIHND--LYVIGGQMKVKNQYLITNC 405

  Fly   447 VEYYDPDLDRWTLVQPMHAKRLGVGVVVVNRLLYAIGGF--------DGNERLAS-VECYHPENN 502
            |:.|..|.|.|..|.|:..:.....||.||..||.|||:        :..:||:: :..|.|..:
  Rat   406 VDKYSVDQDNWKRVSPLPLQLACHAVVSVNNKLYVIGGWTPQMDLPDEEPDRLSNKLLQYDPSQD 470

  Fly   503 EWSFLPPLQTGRSGAGVAAINQYIYVVGGF--------DGTRQLATVERYDTENDTW----DMVA 555
            :|....|:|..:.....|.:|..|||:||.        ...:.|..||.|:.:.|.|    .|.:
  Rat   471 QWRERAPMQYSKYRFSAAVVNSEIYVLGGIGCLGRDKGQVRKCLDVVEIYNPDGDFWREGPPMPS 535

  Fly   556 P-IQIARSALSLTPLDEKLYAIGGFDG---NNFLS--IVEVYDPRTNTWTTGTPLKSGRSGHASA 614
            | :.:..::.|...:|.|||..|||.|   :..:|  |:|: ||..|.|....         .:.
  Rat   536 PLLSLRTNSTSAGAVDGKLYVCGGFHGADRHEVISKEILEL-DPWENQWNVVA---------VNV 590

  Fly   615 VIYQ--PACSTTFMDYED-----SDAPHPDGSNNGER 644
            :::.  ..|....|:..|     ||....||....:|
  Rat   591 LMHDSYDVCLVARMNPRDLIPPPSDLTEEDGDRRQQR 627

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Keap1	NP_732202.2	PHA03098	92..599	CDD:222983	153/565 (27%)
		KELCH repeat	369..416	CDD:276965	10/63 (16%)
		KELCH repeat	420..463	CDD:276965	12/46 (26%)
		KELCH repeat	467..510	CDD:276965	14/51 (27%)
		KELCH repeat	514..558	CDD:276965	15/56 (27%)
		KELCH repeat	561..606	CDD:276965	16/49 (33%)
Kbtbd12	NP_001418799.1	BTB_POZ	10..136	CDD:453885	39/105 (37%)
		PHA03098	29..586	CDD:222983	155/570 (27%)
		BACK_KBTBD12	128..226	CDD:350560	32/97 (33%)
		KELCH repeat	375..422	CDD:276965	12/48 (25%)
		KELCH repeat	426..479	CDD:276965	15/52 (29%)
		KELCH repeat	482..535	CDD:276965	14/52 (27%)
		KELCH repeat	541..587	CDD:276965	16/46 (35%)