DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Keap1 and keap1

DIOPT Version :9

Sequence 1:	NP_732202.2	Gene:	Keap1 / 42062	FlyBaseID:	FBgn0038475	Length:	776	Species:	Drosophila melanogaster
Sequence 2:	NP_001008024.1	Gene:	keap1 / 493386	XenbaseID:	XB-GENE-957785	Length:	613	Species:	Xenopus tropicalis

Alignment Length:	588	Identity:	283/588 - (48%)
Similarity:	385/588 - (65%)	Gaps:	11/588 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 HDATDDDMTFCMSNYAKEALKMMYMMRSHGMLTDVVLEVK----KELFPAHKVVLSAASPYFKAM 118
            |...:....:.::::..:|.::|..:|....|.||.|:||    ::.|.|||:||:::||.|:||
Frog    14 HSNGNRQFQYSLADHTNQAFQIMNELRLGQQLCDVKLKVKYNDVQDEFVAHKIVLASSSPVFRAM 78

  Fly   119 FTGGLKESEMSRVQLQGVCPTAMSRILYFMYTGQIRVTEVTVCQLLPAATMFQVPNVIDACCAFL 183
            ||.||:|..|..|.::||.|..|.|:|.|.||..|.|.|..|..::..|.|:|:.:|:.|||.||
Frog    79 FTNGLRECGMETVTIEGVHPKVMQRLLEFAYTASISVGEKCVIHVMNGAVMYQMDSVVKACCDFL 143

  Fly   184 ERQLDPTNAIGIAHFAEQHGCVELQKKANVFIERNFTQVCQEEEFLQLSAYQLIALIRRDELNVQ 248
            .:||||:||||||.||||.||.||.:||..:|...|.:|.::|||..||:.||:.|:.||||||:
Frog   144 IQQLDPSNAIGIATFAEQIGCHELHQKAREYIYMQFGEVAKQEEFFNLSSCQLVNLVSRDELNVR 208

  Fly   249 EEREVYNAVLKWVKYDEDNRHCKMEHILGAVRCQFLTPNFLKEQMKNCDVLRKVPACREYLAKIF 313
            .|.||::|.:.|||||.:||...::.:|.||||..||||||:.|::.|::|:....|::||::||
Frog   209 CESEVFHACINWVKYDCENRRPYIQALLRAVRCHSLTPNFLQLQLQRCEILKGDSRCQDYLSQIF 273

  Fly   314 KDLTLHK--CPGVKERTPNTTRMIFVAGGFFRHSLDILEAYNVDDMTWTTLANLRIPRSGLGAAF 376
            :||||||  .| ::.|.||..:.|:||||::|.||..|||||..|..|.|||:|.:|||||....
Frog   274 QDLTLHKPTLP-LQGRIPNVPQFIYVAGGYYRQSLSFLEAYNPVDGEWLTLASLEMPRSGLAGCV 337

  Fly   377 LKGKFYAVGGRNNNIGSSYDSDWVDRYSAVTETWRPCAPMSVPRHRVGVAVMDELMYAVGGSAGM 441
            |.|.|||||||||....:.||..:|.|:.:...|.|||.|||||:|||..|:|..:||||||.|.
Frog   338 LGGLFYAVGGRNNAPDCNKDSGALDCYNPMNNQWSPCAAMSVPRNRVGAGVIDGQIYAVGGSHGC 402

  Fly   442 EYHNTVEYYDPDLDRWTLVQPMHAKRLGVGVVVVNRLLYAIGGFDGNERLASVECYHPENNEWSF 506
            .:||:||.|||:.|.|.:|.||..:|:||||.|:||||||:|||||..||.|.|||:||.:||..
Frog   403 LHHNSVERYDPERDEWHMVSPMKTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPETDEWKD 467

  Fly   507 LPPLQTGRSGAGVAAINQYIYVVGGFDGTRQLATVERYDTENDTWDMVAPIQIARSALSLTPLDE 571
            :..:...|||||..|::..:|.:||:|||.||.:|||||.|.|.|..|||::..||||.:|....
Frog   468 IASMNIVRSGAGACALDTSVYAMGGYDGTDQLNSVERYDVEKDDWTFVAPMRHRRSALGVTVHQG 532

  Fly   572 KLYAIGGFDGNNFLSIVEVYDPRTNTWTTGTPLKSGRSGHASAVIYQPA----CSTTFMDYEDSD 632
            |:|.:||:||:.||..||.|:|.|:|||..|.:.|||||...|:..:|.    |..........|
Frog   533 KIYVLGGYDGSTFLDGVECYNPATDTWTEVTQMTSGRSGVGVAITMEPCRKQPCGGGLFPERVKD 597

  Fly   633 APH 635
            ..|
Frog   598 GSH 600

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Keap1	NP_732202.2	BTB	80..183	CDD:279045	46/106 (43%)
		PHA03098	92..599	CDD:222983	264/512 (52%)
		BACK	192..294	CDD:285009	55/101 (54%)
		Kelch	335..379	CDD:128874	25/43 (58%)
		KELCH repeat	369..416	CDD:276965	23/46 (50%)
		Kelch	382..430	CDD:128874	25/47 (53%)
		KELCH repeat	420..463	CDD:276965	23/42 (55%)
		Kelch	433..476	CDD:128874	25/42 (60%)
		KELCH repeat	467..510	CDD:276965	27/42 (64%)
		Kelch	478..523	CDD:128874	25/44 (57%)
		KELCH repeat	514..558	CDD:276965	25/43 (58%)
		Kelch_1	514..556	CDD:279660	23/41 (56%)
		KELCH repeat	561..606	CDD:276965	22/44 (50%)
		Kelch	572..616	CDD:128874	23/43 (53%)
keap1	NP_001008024.1	BTB_POZ_KLHL19_KEAP1	25..148	CDD:349557	50/122 (41%)
		PHA03098	43..560	CDD:222983	266/517 (51%)
		BACK_KLHL19_KEAP1	146..236	CDD:350533	48/89 (54%)
		KELCH repeat	330..377	CDD:276965	23/46 (50%)
		KELCH repeat	381..424	CDD:276965	23/42 (55%)
		KELCH repeat	428..471	CDD:276965	27/42 (64%)
		KELCH repeat	475..519	CDD:276965	25/43 (58%)
		KELCH repeat	522..565	CDD:276965	22/42 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	106	1.000	Domainoid score	I6490
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H8184
Inparanoid	1	1.050	555	1.000	Inparanoid score	I1100
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D312716at33208
OrthoFinder	1	1.000	-	-		FOG0007175
OrthoInspector	1	1.000	-	-		otm49212
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.060