Protein Alignment Keap1 and klhl7

DIOPT Version :10

• Sequence 1: NP_732202.2
• Gene: Keap1 / 42062
• FlyBaseID: FBgn0038475
• Length: 776
• Species: Drosophila melanogaster
• Sequence 2: XP_012819973.1
• Gene: klhl7 / 448292
• XenbaseID: XB-GENE-971613
• Length: 587
• Species: Xenopus tropicalis
• Alignment Length: 571
• Identity: 175/571 - (30%)
• Similarity: 260/571 - (45%)
• Gaps: 70/571 - (12%)

  Fly    73 AKEALKM-------MYMMRSHGMLTDVVLEVKKELFPAHKVVLSAASPYFKAMFTGGLKESEMSR 130
            |:|..|:       |.:||....|.||:|.|:....|||:|||:|||.:|..|||..:.||:...
 Frog    21 AREEAKLLASFMGVMNIMRKQKTLCDVILMVQDRKIPAHRVVLAAASHFFNLMFTTNMLESKSFE 85

  Fly   131 VQLQGVCPTAMSRILYFMYTGQIRVTEVTVCQLLPAATMFQVPNVIDACCAFLERQLDPTNAIGI 195
            |:|:...|..:.:::.|.||.:|.|....|..||.||..:|:..|...|..||:.|:|.:|.:||
 Frog    86 VELKDAEPDIIEQLVEFAYTARISVNSNNVQSLLDAANQYQIEPVKRMCVEFLKEQVDASNCLGI 150

  Fly   196 AHFAEQHGCVELQKKANVFIERNFTQVCQEEEFLQLSAYQLIALIRRDELNVQEEREVYNAVLKW 260
            :..||...|.||:..|:.||.::||:|.:.:|||||...::..|:.:|.|.|:.|.:||:|.::|
 Frog   151 SVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRW 215

  Fly   261 VKYDEDNRHCKMEHILGAVRCQFLTPNFLKEQMKNCDVLRKVPAC-------------------- 305
            :||||.||...|..||..||...::.|||.:.::...:::..|.|
 Frog   216 LKYDEPNRQPYMVDILAKVRFPLISKNFLSKTVQAEPLIQDNPECLKMVISGMRYHLLSPEDREE 280

  Fly   306 -----------REYLAKIF-------------KDLTLH--KCPGVKERTPNTT---RMIFVAGGF 341
                       .:|...:|             ||....  :||..|.|.....   .::::.||.
 Frog   281 LVEGTRPRRKKHDYRIALFGGSQPQSCRYFNPKDYNWSDIRCPFEKRRDAACVFWDNVVYILGGS 345

  Fly   342 FRHSLDILEAYNVDDMTWTTLANLRIPRSGLGAAFLKGKFYAVGGRNNNIGSSYDSDWVDRYSAV 406
            ....:..::.|||...:|.:......||..|.|...:||.|..||......:.|   ..:.|...
 Frog   346 QLFPIKRMDCYNVVKDSWYSKLGPPTPRDSLAACAAEGKIYTSGGSEVGNNALY---LFECYDTR 407

  Fly   407 TETWRPCAPMSVPRHRVGVAVMDELMYAVGGSAGMEYH----NTVEYYDPDLDRWTLVQPMHAKR 467
            ||:|.....|...|...|:...:.|:|..|||.|....    |..|.|||..:.||.:.||...|
 Frog   408 TESWHTKPSMLTQRCSHGMVEANGLIYVCGGSLGNNVSGRVLNCCEVYDPATESWTELCPMIEAR 472

  Fly   468 LGVGVVVVNRLLYAIGGFDGNERLASVECYHPENNEWSFLPPLQTGRSGAGVAAINQYIYVVGGF 532
            ...|:|.|...::||||.:|...|.|||.|..:.|||..:.|:.........||:...|||:.||
 Frog   473 KNHGLVFVKDKIFAIGGQNGLGGLDSVEYYDIKLNEWKMVSPMPWKGVTVKCAAVGSVIYVLAGF 537

  Fly   533 DGTRQLATVERYDTENDTWDMVAPIQIARSALSLTPLDEKLYAIGGFDGNN 583
            .|..:|..:..|:||.|.|       ||.|.:...|:...|..:....|.|
 Frog   538 QGVGRLGHILEYNTEADKW-------IANSKVRAFPVTSCLICVVDTCGAN 581

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Keap1	NP_732202.2	PHA03098	92..599	CDD:222983	167/545 (31%)
		KELCH repeat	369..416	CDD:276965	13/46 (28%)
		KELCH repeat	420..463	CDD:276965	15/46 (33%)
		KELCH repeat	467..510	CDD:276965	17/42 (40%)
		KELCH repeat	514..558	CDD:276965	14/43 (33%)
		KELCH repeat	561..606	CDD:276965	5/23 (22%)
klhl7	XP_012819973.1	BTB_POZ_KLHL7	24..149	CDD:349546	45/124 (36%)
		PHA03098	38..556	CDD:222983	163/520 (31%)
		BACK_KLHL7	141..238	CDD:350522	41/96 (43%)
		KELCH repeat	327..370	CDD:276965	7/42 (17%)
		KELCH repeat	373..417	CDD:276965	13/46 (28%)
		KELCH repeat	421..469	CDD:276965	16/47 (34%)
		KELCH repeat	472..516	CDD:276965	18/43 (42%)