Protein Alignment Keap1 and klhl15

DIOPT Version :10

• Sequence 1: NP_732202.2
• Gene: Keap1 / 42062
• FlyBaseID: FBgn0038475
• Length: 776
• Species: Drosophila melanogaster
• Sequence 2: XP_005162671.1
• Gene: klhl15 / 445186
• ZFINID: ZDB-GENE-040801-99
• Length: 613
• Species: Danio rerio
• Alignment Length: 562
• Identity: 148/562 - (26%)
• Similarity: 248/562 - (44%)
• Gaps: 54/562 - (9%)

  Fly    78 KMMYMMRSHGMLTDVVLEVKKELFPAHKVVLSAASPYFKAMFTGGLKESEMSRVQLQGVCPTAMS 142
            |.:|..|   :|.||.|.:::..|.|||.:|:..|.||:.|||..::|.:..::.::|:......
Zfish    31 KALYEER---LLLDVTLLIEEHHFQAHKALLATQSDYFRVMFTADMRERDQDKIHMKGLTAAGFG 92

  Fly   143 RILYFMYTGQIRVTEVTVCQLLPAATMFQVPNVIDACCAFLERQLDPTNAIGIAHFAEQH--GCV 205
            .:|.|||.|.:.::.:||.::|.||...|:...::.||:||..::...|...:....|..  |..
Zfish    93 HVLRFMYYGSLELSMLTVQEILQAAMYVQLTEAVEFCCSFLLAKICLENCAEVMRLLEDFSVGVE 157

  Fly   206 ELQKKANVFIERNFTQVCQEEEFLQ-LSAYQLIALIRRDELNVQEEREVYNAVLKWVKYDEDN-R 268
            .:|::.:.|:..||..:....:||. ||..:|:|.:..|:|:...|.|:|.||..|:::|... |
Zfish   158 GVQEQLDAFLLENFVPLMARPDFLSYLSLEKLMAYLDSDQLSRFPEIELYEAVQAWLRHDRRRWR 222

  Fly   269 HCKMEHILGAVRCQFLTPNFLKEQMKNCDVLR-------KVPACREYLAKIFKD-LTLHKCPGVK 325
            |  .:.::..:|...:||..:.|::|..:..|       :|.....|..::.:. |...|...::
Zfish   223 H--TDAVVQNLRFCLMTPANIFEKVKTSEFYRYSRQLRLEVDQALSYFHQVNEQPLAETKSNRIR 285

  Fly   326 ERTPNTTRMIFVAGGFFRHSL---DILEAYNVDDMTWTTLANLRIPRSGLGAAFLKGKFYAVGGR 387
            ...|.|.    |..|...||:   .||..:.  ...|..|...::|......|.:....:.:||.
Zfish   286 SVRPQTA----VFRGMIGHSMVNSKILLLHR--PKVWWELEGPQVPLRPDCLAIVNNFAFLLGGE 344

  Fly   388 N-NNIGSSYDSDWVDRYSAVTETWRPCAPMSVPRHRVGVAVMDELMYAVGGSAGMEYHNTVEYYD 451
            . ...|..:.|..|.||.....:|...|.|||||....|.|:.:.:|||.|....|...:.|.||
Zfish   345 ELGPDGEFHASSKVYRYDPRQNSWLRMADMSVPRSEFAVGVIGKYIYAVAGRTRDETFYSTERYD 409

  Fly   452 PDLDRWTLVQPMHAKRLGVGVVVVNRLLYAIGGFDGNERLASVECYHPE---------------N 501
            ...|:|..|.|....:.|....|:|..||..||...:.....|..:.|.               .
Zfish   410 IVEDKWEFVDPYPVNKYGHEGTVLNGKLYITGGITSSSTSKQVCVFDPGREGSSEHRTRRTPILT 474

  Fly   502 NEWSFLPPLQTGRSGAGVAAINQYIYVVGG--------FDGTRQLATVERYDTENDTWDMVAPIQ 558
            |.|.....:...|....:.:.|..:||.||        |: ::...:.|.||.|.|.|.::|.:.
Zfish   475 NCWENKSKMNYARCFHKMISHNGKLYVFGGVCVILRASFE-SQGCPSTEVYDPETDEWTILASMP 538

  Fly   559 IARSALSLTPLDEKLYAIGG--FDGNNFLSIVEVYDPRTNTW 598
            |.||...:..||:::..:||  ::|:...||: .:||..|.|
Zfish   539 IGRSGHGVAVLDKQIMVLGGLCYNGHYSDSIL-TFDPEENKW 579

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Keap1	NP_732202.2	PHA03098	92..599	CDD:222983	143/548 (26%)
		KELCH repeat	369..416	CDD:276965	10/47 (21%)
		KELCH repeat	420..463	CDD:276965	14/42 (33%)
		KELCH repeat	467..510	CDD:276965	11/57 (19%)
		KELCH repeat	514..558	CDD:276965	14/51 (27%)
		KELCH repeat	561..606	CDD:276965	13/40 (33%)
klhl15	XP_005162671.1	BTB_POZ_KLHL15	10..146	CDD:349553	36/117 (31%)
		PHA03098	52..599	CDD:222983	140/538 (26%)
		BACK_KLHL15	137..244	CDD:350529	27/108 (25%)
		KELCH repeat	330..374	CDD:276965	10/43 (23%)
		KELCH repeat	378..421	CDD:276965	14/42 (33%)
		KELCH repeat	426..483	CDD:276965	11/56 (20%)
		KELCH repeat	487..538	CDD:276965	14/51 (27%)
		KELCH repeat	541..581	CDD:276965	13/40 (33%)