Protein Alignment Keap1 and KLHL30

DIOPT Version :10

• Sequence 1: NP_732202.2
• Gene: Keap1 / 42062
• FlyBaseID: FBgn0038475
• Length: 776
• Species: Drosophila melanogaster
• Sequence 2: NP_940984.3
• Gene: KLHL30 / 377007
• HGNCID: 24770
• Length: 578
• Species: Homo sapiens
• Alignment Length: 600
• Identity: 167/600 - (27%)
• Similarity: 268/600 - (44%)
• Gaps: 56/600 - (9%)

  Fly    63 DDMTFCMSNYAKEALKMMYMMRSHGMLTDVVLEVKKELFPAHKVVLSAASPYFKAMFTGGLKESE 127
            ||:.|.:.::|::.|..:..:||...|.||.|.|.....|.|:.:|:.:||||.|||.|...||.
Human     6 DDLDFHLPSHAQDMLDGLQRLRSQPKLADVTLLVGGRELPCHRGLLALSSPYFHAMFAGDFAESF 70

  Fly   128 MSRVQLQGVCPTAMSRILYFMYTGQIRVTEVTVCQLLPAATMFQVPNVIDACCAFLERQLDPTNA 192
            .:||:|:.|.|..:.:::.|:|||::.:|:..|..|...|.....|:|...|..:|::|||..|.
Human    71 SARVELRDVEPAVVGQLVDFVYTGRLTITQGNVEALTRTAARLHFPSVQKVCGRYLQQQLDAANC 135

  Fly   193 IGIAHFAEQHGCVELQKKANVFIERNFTQVCQEEEFLQLSAYQLIALIRRDELNVQEEREVYNAV 257
            :||..|.||.|.:.:..||..|:..||..|.:|:|||||...:|:..:..|.|.||.|:....|:
Human   136 LGICEFGEQQGLLGVAAKAWAFLRENFEAVAREDEFLQLPRERLVTCLAGDLLQVQPEQSRLEAL 200

  Fly   258 LKWVKYDEDNRHCKMEHILGAVRCQFLTPNFLKEQMKNCDVLRKVPACREYLAKIFKDLTLHKCP 322
            ::||::|...|...:..:|..|....:....:::.:.:..::::..|||..|::......|....
Human   201 MRWVRHDPQARAAHLPELLSLVHLDAVPRPCVQQLLASEPLIQESEACRAALSQGHDGAPLALQQ 265

  Fly   323 GVKERTPNTTRMIFVAGGFFRHSLDILEA-------------YNVDDMTWTTLANLRIP---RSG 371
            .::|       ::.|.||   .:|:..||             ||.....|..|.:  .|   :.|
Human   266 KLEE-------VLVVVGG---QALEEEEAGEEPTPGLGNFAFYNSKAKRWMALPD--FPDYHKWG 318

  Fly   372 LGAAFLKGKFYAVGGRNNNIGSSYDSDWVDRYSAVTETWRPCAPMSVPRHRVGVAVMDELMYAVG 436
            ...|.|....|..||.......::.:.....:.....:|:|.|||..||.....|.::..:|.:|
Human   319 FSLAALNNNIYVTGGSRGTKTDTWSTTQAWCFPLKEASWKPVAPMLKPRTNHASAALNGEIYVIG 383

  Fly   437 GSA--GMEYHNTVEYYDPDLDRWTLVQPMHAKRLGVGVVVVNRLLYAIGGFDGNERLASVECYHP 499
            |:.  .:|    ||.|||..|.||.|.|................||.:|.........:::||:|
Human   384 GTTLDVVE----VESYDPYTDSWTPVSPALKYVSNFSAAGCRGRLYLVGSSACKYNALALQCYNP 444

  Fly   500 ENNEWSFL--PPLQTGRSGAGVAAINQYIYVVGGFDGTRQLATVERYDTENDTWDMVAPIQIARS 562
            ..:.||.:  |.|....|....||::..:|::|  |.|::   |..||...:.|..|........
Human   445 VTDAWSVIASPFLPKYLSSPRCAALHGELYLIG--DNTKK---VYVYDPGANLWQKVQSQHSLHE 504

  Fly   563 ALSLTPLDEKLYAIG----GFDGNNFLSIVEVYDPRTNTWTTGTPLKSGRSGHASAVIYQPACST 623
            ..:|.||.:.||..|    |.:|:..:. :|.||...:|||        |.|....:......||
Human   505 NGALVPLGDALYVTGGRWQGMEGDYHVE-MEAYDTVRDTWT--------RHGALPRLWLYHGAST 560

  Fly   624 TFMDYEDSDAPHPDG 638
            .|:|.  |....|.|
Human   561 VFLDV--SKWTQPSG 573

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Keap1	NP_732202.2	PHA03098	92..599	CDD:222983	147/530 (28%)
		KELCH repeat	369..416	CDD:276965	9/46 (20%)
		KELCH repeat	420..463	CDD:276965	15/44 (34%)
		KELCH repeat	467..510	CDD:276965	9/44 (20%)
		KELCH repeat	514..558	CDD:276965	12/43 (28%)
		KELCH repeat	561..606	CDD:276965	14/48 (29%)
KLHL30	NP_940984.3	BTB_POZ	1..137	CDD:453885	46/130 (35%)
		PHA03098	29..550	CDD:222983	153/550 (28%)
		BACK_KLHL30	128..231	CDD:350544	35/102 (34%)
		Kelch 1	270..326		14/60 (23%)
		KELCH repeat	318..363	CDD:276965	9/44 (20%)
		Kelch 2	327..377		11/49 (22%)
		KELCH repeat	367..409	CDD:276965	16/45 (36%)
		Kelch 3	378..422		14/47 (30%)
		KELCH repeat	412..454	CDD:276965	8/41 (20%)
		Kelch 4	424..471		13/46 (28%)
		KELCH repeat	461..498	CDD:276965	12/41 (29%)
		Kelch 5	473..513		12/44 (27%)
		KELCH repeat	503..550	CDD:276965	16/55 (29%)
		Kelch 6	514..563		15/57 (26%)