DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Keap1 and CG15097

DIOPT Version :9

Sequence 1:	NP_732202.2	Gene:	Keap1 / 42062	FlyBaseID:	FBgn0038475	Length:	776	Species:	Drosophila melanogaster
Sequence 2:	NP_001261079.1	Gene:	CG15097 / 37172	FlyBaseID:	FBgn0034396	Length:	743	Species:	Drosophila melanogaster

Alignment Length:	763	Identity:	220/763 - (28%)
Similarity:	343/763 - (44%)	Gaps:	106/763 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 NHKGYPCRPEEAEMSNTSESCSISCGGRFGSAHSTLDDHD-------------ATDDDMTFCMSN 71
            ||.|        |.|..:|..:.:      |.:||....|             |...:...|:::
  Fly     8 NHSG--------EASGNNEDVTTT------SNNSTQTPSDLSPPGPNEEVLPQAHHQNPGHCIAS 58

  Fly    72 YAKEALKMMYMMRSHGMLTDVVLEVKKELFPAHKVVLSAASPYFKAMFTGGLKESEMSRVQLQGV 136
            :|     .:..||::..|.||.|||..:...||:|||::.||||.|||...:.|.....|:|..|
  Fly    59 FA-----AINQMRNNAQLCDVRLEVGGDTINAHRVVLASVSPYFYAMFNDDMLERTQGLVRLHDV 118

  Fly   137 CPTAMSRILYFMYTGQIRVTEVTVCQLLPAATMFQVPNVIDACCAFLERQLDPTNAIGIAHFAEQ 201
            ..:|:.:::.:.|||:|.:||..|..||||:.:.|:.:|.||||.||.|||.|:|.:||..||:.
  Fly   119 DSSALRQLIDYTYTGEITITEQNVQVLLPASGLLQMHSVRDACCKFLLRQLHPSNCLGIRSFADA 183

  Fly   202 HGCVELQKKANVFIERNFTQVCQEEEFLQLSAYQLIALIRRDELNVQEEREVYNAVLKWVKYDED 266
            |.|.||..:::.:..:||.||...||||.|...::..||...:||:..|..|:.||:.|||:|..
  Fly   184 HSCKELHTRSHKYALQNFQQVVGTEEFLLLPFEEVRELISNSQLNISSEERVFAAVINWVKHDLP 248

  Fly   267 NRHCKMEHILGAVRCQFLTPNFLKEQMKNCDVLRKVPACREYLAKIFKDLTLHKCP--------- 322
            .|...:..::..||...::.:||...::...::|....|:|.|.:..|   .|..|
  Fly   249 TRRLHIAELMSNVRLPLVSRDFLMSCVETETLMRDDSECKELLLEAMK---YHLLPEQRSIMGSQ 310

  Fly   323 GVKERTPNTTR-MIFVAGG---FFRHSLDILEAYNVDDMTWTTLANLRIPRSGLGAAFLKGKFYA 383
            ..:||.|...: .:|..||   |..|  :..|.||....:|:.:|.:...||..|...|..:.|.
  Fly   311 RTQERRPEGMKPYVFAVGGGSLFAIH--NECEVYNPRSNSWSPVAPMLWRRSRSGVTSLHKQLYV 373

  Fly   384 VGGRNNNIGSSYD--SD--WVDRYSAVTETWRPCAPMSVPRHRVGVAVMDELMYAVGGSAGMEYH 444
            |||        ||  ||  ..:.|:.:|..|....||...|..:|:...|.|:|..||..|....
  Fly   374 VGG--------YDGVSDLATAESYNPLTNKWSNITPMGTKRSCLGICSYDALIYVCGGYDGASCL 430

  Fly   445 NTVEYYDPDLDRWTLVQPMHAKRLGVGVVVVNRLLYAIGGFDGNERLASVECYHPENNEWSFLPP 509
            :::|.|||....|:....|..:|....:.|:...:|::||||.....:|||.:.|....|..:|.
  Fly   431 SSMERYDPLTGIWSSCPAMSTRRRYCRLAVLENCIYSLGGFDSTNYQSSVERFDPRVGRWQPVPS 495

  Fly   510 LQTGRSGAGVAAINQYIYVVGGFDGTRQLATVERYDTENDTWDMVAPIQIARSALSLTPLDEKLY 574
            :...||..|||:.:.::|.:||.|||..:::.||:....::|:.:|.:...||...:..::..|:
  Fly   496 MSARRSSCGVASTDGHLYCIGGNDGTMCMSSGERFSLRRNSWEPIAAMHSRRSTHEVVEVEGALF 560

  Fly   575 AIGGFDGNNFLSIVEVYDPRTNTWTTGTPLKSGRSGHASAVI--------------YQPACSTTF 625
            |:||.||::.|:.||.||.|.|.|:....:.:.||...:||:              . |..|.|
  Fly   561 ALGGNDGSSSLNSVERYDTRLNKWSVVNAMVARRSSVGAAVLECFHLERGLVQTTNLXPLASIT- 624

  Fly   626 MDYEDSDAPHPDGSNNGERNAHTPQNTYGSGSPHYPGTASNMQFHTSYGMSGCNNCDSEMDIKPY 690
               |...|....|::||    ::..|..|||.          ...:|.|:.|.....|..:...:
  Fly   625 ---ESFAAAAASGTSNG----NSTINGIGSGG----------VIPSSSGVGGTLTVPSRAEAAAF 672

  Fly   691 IPAEHHSFQIPAIRSEELVNPNCPWSRMQERFRRTPPASFTDDERNAN 738
            ......|...|:.            |....|.||..|........|:|
  Fly   673 TANIALSSSAPSA------------SSTLRRHRRDTPGLAESRRANSN 708

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Keap1	NP_732202.2	BTB	80..183	CDD:279045	42/102 (41%)
		PHA03098	92..599	CDD:222983	173/523 (33%)
		BACK	192..294	CDD:285009	34/101 (34%)
		Kelch	335..379	CDD:128874	14/46 (30%)
		KELCH repeat	369..416	CDD:276965	15/50 (30%)
		Kelch	382..430	CDD:128874	15/51 (29%)
		KELCH repeat	420..463	CDD:276965	13/42 (31%)
		Kelch	433..476	CDD:128874	12/42 (29%)
		KELCH repeat	467..510	CDD:276965	13/42 (31%)
		Kelch	478..523	CDD:128874	16/44 (36%)
		KELCH repeat	514..558	CDD:276965	15/43 (35%)
		Kelch_1	514..556	CDD:279660	14/41 (34%)
		KELCH repeat	561..606	CDD:276965	16/44 (36%)
		Kelch	572..616	CDD:128874	17/43 (40%)
CG15097	NP_001261079.1	BTB	63..166	CDD:279045	43/102 (42%)
		PHA03098	65..539	CDD:222983	161/486 (33%)
		BACK	174..276	CDD:285009	34/101 (34%)
		Kelch	324..369	CDD:128874	14/46 (30%)
		KELCH repeat	359..402	CDD:276965	15/50 (30%)
		Kelch	370..415	CDD:128874	15/52 (29%)
		KELCH repeat	406..450	CDD:276965	13/43 (30%)
		Kelch	417..463	CDD:128874	13/45 (29%)
		KELCH repeat	453..496	CDD:276965	13/42 (31%)
		Kelch	464..510	CDD:128874	16/45 (36%)
		Kelch_1	499..543	CDD:279660	15/43 (35%)
		KELCH repeat	500..545	CDD:276965	15/44 (34%)
		KELCH repeat	547..590	CDD:276965	16/42 (38%)
		Kelch	559..603	CDD:128874	18/43 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45464357
Domainoid	1	1.000	52	1.000	Domainoid score	I4252
eggNOG	1	0.900	-	-		E1_KOG4441
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	57	1.000	Inparanoid score	I2576
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D26788at33392
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm2846
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24412
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	8	7.900