DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Keap1 and IPP

DIOPT Version :9

Sequence 1:NP_732202.2 Gene:Keap1 / 42062 FlyBaseID:FBgn0038475 Length:776 Species:Drosophila melanogaster
Sequence 2:NP_005888.1 Gene:IPP / 3652 HGNCID:6108 Length:584 Species:Homo sapiens


Alignment Length:571 Identity:193/571 - (33%)
Similarity:293/571 - (51%) Gaps:49/571 - (8%)


- Green bases have known domain annotations that are detailed below.


  Fly    64 DMTFCMSNYAKEALKMMYMMRSHGMLTDVVLEVKKELFPAHKVVLSAASPYFKAMFTGGLKESEM 128
            |..|....:|:..|..:..||:.....||.|:|.:|.|.||::||:|:||||.|:||||:|||..
Human    11 DSPFSSDKHAQLILAQINKMRNGQHFCDVQLQVGQESFKAHRLVLAASSPYFAALFTGGMKESSK 75

  Fly   129 SRVQLQGVCPTAMSRILYFMYTGQIRVTEVTVCQLLPAATMFQVPNVIDACCAFLERQLDPTNAI 193
            ..|.:.|:.......:|.|:|||.:.:....|.:|:.||.|.|:..|:..||.||:.|:||.|.|
Human    76 DVVPILGIEAGIFQILLDFIYTGIVNIGVNNVQELIIAADMLQLTEVVHLCCEFLKGQIDPLNCI 140

  Fly   194 GIAHFAEQHGCVELQKKANVFIERNFTQVCQEEEFLQLSAYQLIALIRRDELNVQEEREVYNAVL 258
            ||..|:||..|.:|.:.:..:|..:|.:|...||||.|:..|||.::|.:||::::|.:|:.|.:
Human   141 GIFQFSEQIACHDLLEFSENYIHVHFLEVHSGEEFLALTKDQLIKILRSEELSIEDEYQVFLAAM 205

  Fly   259 KWVKYDEDNRHCKMEHILGAVRCQFLTPNFLKEQMKNCDVLRKVPACREYLAKIFKDLTLHK--- 320
            :|:..|...|...:..:|..:|...|.|..|         |:.:....::..::.....|.:   
Human   206 QWILKDLGKRRKHVVEVLDPIRFPLLPPQRL---------LKYIEGVSDFNLRVALQTLLKEYCE 261

  Fly   321 -CPGVKER-------------TPNTTRMIFVAGGFFR---------HSLDILEAYNVDDMTWTTL 362
             |...||.             .....:.::..||:.|         .:|..:|.::.....|||:
Human   262 VCKSPKENKFCSFLQTSKVRPRKKARKYLYAVGGYTRLQGGRWSDSRALSCVERFDTFSQYWTTV 326

  Fly   363 ANLRIPRSGLGAAFLKGKFYAVGGRNNNIGSSYDSDWVDRYSAVTETWRPCAPMSVPRHRVGVAV 427
            ::|...|||||...|.|..||:||..:    |...|..:.|..||:.|...|.|:.||..:||.|
Human   327 SSLHQARSGLGVTVLGGMVYAIGGEKD----SMIFDCTECYDPVTKQWTTVASMNHPRCGLGVCV 387

  Fly   428 MDELMYAVGGSAGMEYHNTVEYYDPDLDRWTLVQPMHAKRLGVGVVVVNRLLYAIGGFDGNE--R 490
            ....:||:||..|.|..||:|.:|||.::|.:|..|...|...|...:..|:|.|||. .||  .
Human   388 CYGAIYALGGWVGAEIGNTIERFDPDENKWEVVGNMAVSRYYFGCCEMQGLIYVIGGI-SNEGIE 451

  Fly   491 LASVECYHPENNEWSFLPPLQTGRSGAGVAAINQYIYVVGGFDGTRQ-LATVERYDTENDTWDMV 554
            |.|.|.|.|.:..||.|||:.|.|:..||||:|..||.|||::.|:. |.|||:|..|.:.|..|
Human   452 LRSFEVYDPLSKRWSPLPPMGTRRAYLGVAALNDCIYSVGGWNETQDALHTVEKYSFEEEKWVEV 516

  Fly   555 APIQIARSALSLTPLDEKLYAIGG------FDGNNFLSIVEVYDPRTNTWT 599
            |.:::.|:.:.:..::..||..||      |.....|..||||:|.::|||
Human   517 ASMKVPRAGMCVVAVNGLLYVSGGRSSSHDFLAPGTLDSVEVYNPHSDTWT 567

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Keap1NP_732202.2 BTB 80..183 CDD:279045 41/102 (40%)
PHA03098 92..599 CDD:222983 184/541 (34%)
BACK 192..294 CDD:285009 33/101 (33%)
Kelch 335..379 CDD:128874 15/52 (29%)
KELCH repeat 369..416 CDD:276965 18/46 (39%)
Kelch 382..430 CDD:128874 17/47 (36%)
KELCH repeat 420..463 CDD:276965 18/42 (43%)
Kelch 433..476 CDD:128874 17/42 (40%)
KELCH repeat 467..510 CDD:276965 18/44 (41%)
Kelch 478..523 CDD:128874 23/46 (50%)
KELCH repeat 514..558 CDD:276965 21/44 (48%)
Kelch_1 514..556 CDD:279660 20/42 (48%)
KELCH repeat 561..606 CDD:276965 15/45 (33%)
Kelch 572..616 CDD:128874 14/34 (41%)
IPPNP_005888.1 PHA03098 30..575 CDD:222983 189/552 (34%)
Kelch 1 289..343 15/53 (28%)
KELCH repeat 333..376 CDD:276965 18/46 (39%)
Kelch 2 344..390 17/49 (35%)
KELCH repeat 380..424 CDD:276965 18/43 (42%)
Kelch 3 391..437 17/45 (38%)
KELCH repeat 427..473 CDD:276965 19/46 (41%)
Kelch 4 439..485 22/46 (48%)
KELCH repeat 475..520 CDD:276965 21/44 (48%)
Kelch 5 487..533 16/45 (36%)
KELCH repeat 523..574 CDD:276965 15/45 (33%)
Kelch 6 535..583 14/33 (42%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4441
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D312716at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X9
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.820

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