Protein Alignment Keap1 and KLHL38

DIOPT Version :10

• Sequence 1: NP_732202.2
• Gene: Keap1 / 42062
• FlyBaseID: FBgn0038475
• Length: 776
• Species: Drosophila melanogaster
• Sequence 2: NP_001075144.2
• Gene: KLHL38 / 340359
• HGNCID: 34435
• Length: 581
• Species: Homo sapiens
• Alignment Length: 596
• Identity: 160/596 - (26%)
• Similarity: 267/596 - (44%)
• Gaps: 67/596 - (11%)

  Fly    63 DDMTFCMSNYAKEALKMMYMMRSHGMLTDVVLEVKKELFPAHKVVLSAASPYFKAMFTGGLKESE 127
            |.:.|...:::.:.|:.:..:|...:||||.:.......|.|:.||:::||||:|||....:|..
Human     7 DGLLFKDHDFSSDLLRQLNSLRQSRILTDVSICAGAREIPCHRNVLASSSPYFRAMFCSSFREKS 71

  Fly   128 MSRVQLQGVCPTAMSRILYFMYTGQIRVTEVTVCQLLPAATMFQVPNVIDACCAFLERQLDPTNA 192
            .::|||:|:.|..:.:|:.::|||:..:....|..::.||:|.|.|.:.:||.::|:.||.|:|.
Human    72 EAKVQLKGIDPPTLDQIVSYVYTGEAHIATDNVLPVMEAASMLQFPKLFEACSSYLQSQLAPSNC 136

  Fly   193 IGIAHFAEQHGCVELQKKANVFIERNFTQVCQEEEFLQLSAYQLIALIRRDELNVQEEREVYNAV 257
            :|:...:|...|..|:|||......:|.:|....:..:|.|.:|...:..|.| ..||.:|:.|:
Human   137 LGMIRLSEILSCETLKKKAREVALTSFPEVAASADLKELCALELRDYLGDDGL-CGEEEKVFEAL 200

  Fly   258 LKWVKYDEDNRHCKMEHILGAVRCQFLTPNFLKEQMKNCDVLRKVPACREYL----AKIFK---- 314
            :.|:|:|...|...|:.:...||.|::.|.|....:.|..:|:..|||:..|    .::|.
Human   201 MVWIKHDLQARKRYMQELFKQVRLQYIHPAFFHHFIANDALLQSSPACQIILETAKRQMFSLCGT 265

  Fly   315 -----DLTLHKCP-----------GVKERTPNTTRMIFVAGGFFRHSLDILEAYNVDDMTWTTLA 363
                 .|.||..|           |.::.:..|||             |:| .|:.....|.:||
Human   266 TVPDCKLLLHVPPRNSYQDFLILLGGRKDSQQTTR-------------DVL-LYSKQTGQWQSLA 316

  Fly   364 NLRIPRSGLGAAFLKGKFYAVGGRNNNIGSSYDSDWVDRYSAVTETWRPCAPMSVPRHRVGVAVM 428
            .|........|..|....|.:||...:.|.|..|..|..:|.....||...||.|.|:.......
Human   317 KLPTRLYKASAITLHRSIYVLGGMAVSSGRSLVSHNVYIFSLKLNQWRLGEPMLVARYSHRSTAH 381

  Fly   429 DELMYAVGG-SAGMEYHNTVEYYDPDLDRWTLVQPMHAKRLGVGVVVVNRLLYAIGGFDGNER-L 491
            ...::::|| ..|.|...::|.||...:.|..:..|....|...|.|.::.||..||.|..:. :
Human   382 KNFIFSIGGIGEGQELMGSMERYDSICNVWESMASMPVGVLHPAVAVKDQRLYLFGGEDIMQNPV 446

  Fly   492 ASVECYHPENNEWSFLPPLQTGRSGAGVAAINQYIYVVGGFDGTRQLATVERYDTENDTWDMVAP 556
            ..::.||...|.|..:.........|....:.:.|.:|||:  ||::..   ||.:::.:...|.
Human   447 RLIQVYHISRNSWFKMETRMIKNVCAPAVVLGERIVIVGGY--TRRILA---YDPQSNKFVKCAD 506

  Fly   557 IQIARSALSLTPLDEKLYAIGG---------FDGNNFLSIVEVYDPRTNTWTTGTPLKSGRSGHA 612
            ::..|.....|.:..|||..||         .|..:|    :.|||.|:|||:     .|:..|.
Human   507 MKDRRMHHGATVMGNKLYVTGGRRLTTDCNIEDSASF----DCYDPETDTWTS-----QGQLPHK 562

  Fly   613 SAVIYQPACST 623
               ::..||.|
Human   563 ---LFDHACLT 570

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Keap1	NP_732202.2	PHA03098	92..599	CDD:222983	146/541 (27%)
		KELCH repeat	369..416	CDD:276965	12/46 (26%)
		KELCH repeat	420..463	CDD:276965	9/43 (21%)
		KELCH repeat	467..510	CDD:276965	12/43 (28%)
		KELCH repeat	514..558	CDD:276965	10/43 (23%)
		KELCH repeat	561..606	CDD:276965	16/53 (30%)
KLHL38	NP_001075144.2	BTB_POZ_KLHL38	11..139	CDD:349577	41/127 (32%)
		BACK_KLHL38	131..229	CDD:350551	29/98 (30%)
		Kelch 1	285..332		13/60 (22%)
		NanM	287..528	CDD:442289	63/259 (24%)
		KELCH repeat	325..369	CDD:276965	12/43 (28%)
		Kelch 2	334..383		14/48 (29%)
		KELCH repeat	373..417	CDD:276965	9/43 (21%)
		Kelch 3	384..431		12/46 (26%)
		KELCH repeat	421..508	CDD:276965	22/91 (24%)
		Kelch 4	433..479		10/45 (22%)
		Kelch 5	480..521		11/45 (24%)
		Kelch_1	510..560	CDD:396078	17/58 (29%)
		KELCH repeat	511..561	CDD:276965	17/58 (29%)
		Kelch 6	523..573		18/60 (30%)