DRSC/TRiP Functional Genomics Resources

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Protein Alignment Keap1 and CG1812

DIOPT Version :9

Sequence 1:NP_732202.2 Gene:Keap1 / 42062 FlyBaseID:FBgn0038475 Length:776 Species:Drosophila melanogaster
Sequence 2:NP_608397.1 Gene:CG1812 / 33049 FlyBaseID:FBgn0031119 Length:616 Species:Drosophila melanogaster


Alignment Length:583 Identity:148/583 - (25%)
Similarity:252/583 - (43%) Gaps:41/583 - (7%)


- Green bases have known domain annotations that are detailed below.


  Fly    77 LKMMYMMRSHGMLTDVVLEVKKELFPAHKVVLSAASPYFKAMFTG-GLKESEMSRVQLQGVCPTA 140
            |:.:..:|:...||||.|.|::..|.||:|||:|:|.||.|||.. .:.||....:.|.|:...|
  Fly    35 LRGLNKLRNEEKLTDVTLIVEEHRFKAHRVVLAASSDYFCAMFADCAMIESRKDEINLYGIKARA 99

  Fly   141 MSRILYFMYTGQIRVTEVTVCQLLPAATMFQVPNVIDACCAFLERQLDPTNAIGIAHFAEQHGCV 205
            |..|:.::||..:.:....:.::|.|||..||..|||.|..||..:::..|.:.||..|:.:|.:
  Fly   100 MGSIIDYIYTSMLELNYDNIEEILAAATHVQVREVIDRCTIFLGAKIEMENCLAIAGMADIYGIM 164

  Fly   206 ELQKKANVFIERNFTQVCQEEEFLQLSAYQLIALIRRDELNVQEEREVYNAVLKWVKYDEDNRHC 270
            :|.::|..::..:|.:.....:|.::...||..::..:......|:::...|..:. .::.....
  Fly   165 DLSERAYRYMCAHFEEFATTSDFKEMKVDQLRFILSSNYPIDVAEQDLVRLVCSFA-IEQQLNES 228

  Fly   271 KMEHILGAVRCQFLTPNFLKE-QMKNC--DVLRKVPACREYLAKIFKDLTLHKCPGV---KERT- 328
            .:..:|..::.|.::...:.| :..||  |..:::|....|..:|.::...|...||   |::: 
  Fly   229 ALGDLLRLIKWQHISYKSVDELRNMNCSLDKGKQLPLPTSYYNRIKQEHMGHLLNGVVSLKDQSL 293

  Fly   329 ---PNTTR----MIFVAGGFFRHSL-DILEAYNVDDMTWTTLANL-RIPRSGLGAAFLKGKFYAV 384
               |...|    .:...|||..:.| :::..::...|.|..|..: .|.:...|.|.|..|.:.|
  Fly   294 PQGPTNMRGMELCLLKIGGFEWNGLTNVIMCFSPKKMNWYELTAIPHIDQCNFGTAVLNNKLFIV 358

  Fly   385 GGRNNNIGSSYDSDWVDRYSAVTETWRPCAPMSVPRHRVGV-AVMDELMYAVGG------SAGME 442
            ||..:.....|...:...|..:..||...||:...|.|..: ||..:.:|||||      ...:.
  Fly   359 GGAYDVFLKEYIHPFGFCYCPLRNTWMTIAPIQQDRCRFSLNAVGTQHLYAVGGILDDDNEEALR 423

  Fly   443 YHNTVEYYDPDLDRWTLVQPMHAKRLGVGVVVVNRLLYAIGGFDGNERLASVECYHPENNEWSFL 507
            ..:.||.||...:.||.:..:...|.....|||...||..||......|||:..:..:...|..|
  Fly   424 MISNVERYDIAKNVWTYMPSLQENRSQHAGVVVGDKLYISGGVHLANILASMWVFDTKTEVWQEL 488

  Fly   508 PPLQTGRSGAGVAAINQYIYVVGGFDG--TRQLATVER---YDTENDTWDMVAPIQIARSALSLT 567
            ..:.|......:.|::..||..||:..  |.....||.   ||.|.:||.:...|...:....:|
  Fly   489 ASMPTPCCDHVLVAVDNRIYACGGWHESLTEWRVLVEHIYAYDIETNTWSVETKIPAPKFYTGVT 553

  Fly   568 PLDEKLYAIGGFDGNNFLSIVE----VYDPRTNTW-----TTGTPLKSGRSGHASAVIYQPAC 621
            .:...::.:||.|....:....    .||..|..|     :..:|.....|  ....||.|.|
  Fly   554 AMGRTIFFVGGLDSTESIDRASAETMAYDLDTKEWWHEKDSWDSPNDVWES--TCVAIYVPNC 614

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Keap1NP_732202.2 BTB 80..183 CDD:279045 39/103 (38%)
PHA03098 92..599 CDD:222983 137/544 (25%)
BACK 192..294 CDD:285009 15/102 (15%)
Kelch 335..379 CDD:128874 11/45 (24%)
KELCH repeat 369..416 CDD:276965 12/46 (26%)
Kelch 382..430 CDD:128874 13/48 (27%)
KELCH repeat 420..463 CDD:276965 15/49 (31%)
Kelch 433..476 CDD:128874 14/48 (29%)
KELCH repeat 467..510 CDD:276965 13/42 (31%)
Kelch 478..523 CDD:128874 11/44 (25%)
KELCH repeat 514..558 CDD:276965 13/48 (27%)
Kelch_1 514..556 CDD:279660 13/46 (28%)
KELCH repeat 561..606 CDD:276965 9/53 (17%)
Kelch 572..616 CDD:128874 9/52 (17%)
CG1812NP_608397.1 BTB 38..142 CDD:279045 39/103 (38%)
PHA03098 46..588 CDD:222983 139/542 (26%)
BACK 151..249 CDD:285009 14/98 (14%)
KELCH repeat 344..390 CDD:276965 12/45 (27%)
KELCH repeat 394..444 CDD:276965 15/49 (31%)
Kelch 406..458 CDD:128874 15/51 (29%)
Kelch_1 448..492 CDD:279660 13/43 (30%)
KELCH repeat 448..492 CDD:276965 13/43 (30%)
Kelch_1 494..539 CDD:279660 13/44 (30%)
KELCH repeat 495..539 CDD:276965 13/43 (30%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 52 1.000 Domainoid score I4252
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 57 1.000 Inparanoid score I2576
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X9
43.960

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