Protein Alignment Keap1 and enc3

DIOPT Version :10

• Sequence 1: NP_732202.2
• Gene: Keap1 / 42062
• FlyBaseID: FBgn0038475
• Length: 776
• Species: Drosophila melanogaster
• Sequence 2: NP_001001402.2
• Gene: enc3 / 327531
• ZFINID: ZDB-GENE-030131-5742
• Length: 589
• Species: Danio rerio
• Alignment Length: 582
• Identity: 161/582 - (27%)
• Similarity: 262/582 - (45%)
• Gaps: 43/582 - (7%)

  Fly    67 FCMSNYAKEALKMMYMMRSHGMLTDVVLEVKKELFPAHKVVLSAASPYFKAMFTGGLKESEMSRV 131
            |..:::|...|..:.::|...:.|||||.....:||.|:.||::.|.||:|||:||||||..:.|
Zfish    23 FHKTSHADSLLTHLNLLRKRRVFTDVVLRAGHRVFPCHRAVLASCSRYFEAMFSGGLKESRDAEV 87

  Fly   132 QL-QGVCPTAMSRILYFMYTGQIRVTEVTVCQLLPAATMFQVPNVIDACCAFLERQLDPTNAIGI 195
            .. ..:.|..:..:|.:.|:.::.:.|.....||.|..|.|..::.||...|||:.|.|:|.:|:
Zfish    88 NFHDSLHPEVLELLLDYAYSARVIINEENAESLLEAGDMLQFHDIRDAASEFLEKNLHPSNCLGM 152

  Fly   196 AHFAEQHGCVELQKKANVFIERNFTQVCQEEEFLQLSAYQLIALIRRDELNVQEEREVYNAVLKW 260
            ...::.|.|..|.:.:......||..:...|:||.|...::..|:..:||.|::|..||.||:.|
Zfish   153 MLLSDAHQCQRLYELSWRMCLANFANLYHTEDFLSLPKDKVQELVFSEELEVEDESIVYEAVIDW 217

  Fly   261 VKYDEDNRHCKMEHILGAVRCQFLTPNFLKEQMKNCDVLRKVPACREYLAKIFKDLTLHKC---- 321
            |:.|...||..:..:|..||...|...:|.:.:.:.:::......||    |.:|..  :|
Zfish   218 VRADIGRRHLDLPDLLRCVRLALLPETYLLKNVASEELVMGHKVGRE----IVEDAV--RCKMKI 276

  Fly   322 -------PGVKERTPNTTRMIFVAGGFFRHSLDILEAYNVDDMT--WTTLANLRIPRSGLGAAFL 377
                   .|...|....::.:.:.||   .:....:.|.:|...  .|...:|..||....|..:
Zfish   277 LQNDGVVTGFCARPRKVSQALLLLGG---QTFMCDKVYMIDHKAKEITPKTDLPSPRKECSACAI 338

  Fly   378 KGKFYAVGGRNNNIGSSYDSDWVDRYSAVTETWRPCAPMSVPRHRVGVAVMDELMYAVGGSAGME 442
            ..|.|..|||.:..|:|.|. ||  |..:.:.|...|.|.|.|...|.|.:|.::|.|||...:.
Zfish   339 GCKVYVTGGRGSENGASKDV-WV--YDTLHDEWSKAAQMLVARFGHGSAELDHILYVVGGHTSLA 400

  Fly   443 YH---------NTVEYYDPDLDRWTLVQPMHAKRLGVGVVVVNRLLYAIGGFDGN-ERLASVECY 497
            ..         ..||.|:|..::||||.|:........||.....|:|.||...| ::...|:|:
Zfish   401 GSFPASPSVSLKQVEQYNPQSNKWTLVAPLREGVSNAAVVGAKNKLFAFGGTSVNRDKYPKVQCF 465

  Fly   498 HPENNEWSFLPPL--QTGRSGAGVAAINQYIYVVGGFDGTRQLATVERYDTENDTWDMVAPIQIA 560
            .|..|.|: :|..  |..|..| .|.:..::.|:|| |.....::..|:::|...|.....:...
Zfish   466 DPCENRWT-VPATCPQLWRYTA-AAVVGNHVVVIGG-DTEFSASSAYRFNSETFQWTKFGDVTSK 527

  Fly   561 RSALSLTPLDEKLYAIGGFDGNNFLSIVEVYDPRTNTW--TTGTPLKSGRSGHASAVIYQPA 620
            |.:........:||.:||:.|......::.|||.|::|  .|..|.....:...|...|.|:
Zfish   528 RISCHAVASGNRLYVVGGYFGAQRCKTLDCYDPSTDSWDSITSVPYSLIPTAFVSTWKYLPS 589

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Keap1	NP_732202.2	PHA03098	92..599	CDD:222983	150/534 (28%)
		KELCH repeat	369..416	CDD:276965	15/46 (33%)
		KELCH repeat	420..463	CDD:276965	16/51 (31%)
		KELCH repeat	467..510	CDD:276965	13/43 (30%)
		KELCH repeat	514..558	CDD:276965	10/43 (23%)
		KELCH repeat	561..606	CDD:276965	13/46 (28%)
enc3	NP_001001402.2	BTB_POZ	6..152	CDD:453885	44/128 (34%)
		PHA03098	60..566	CDD:222983	144/520 (28%)
		BACK_KLHL25_like	145..242	CDD:350539	29/96 (30%)
		KELCH repeat	330..374	CDD:276965	15/46 (33%)
		KELCH repeat	378..431	CDD:276965	17/52 (33%)
		KELCH repeat	434..480	CDD:276965	13/46 (28%)
		KELCH repeat	528..570	CDD:276965	11/41 (27%)