Protein Alignment Keap1 and keap1a

DIOPT Version :10

• Sequence 1: NP_732202.2
• Gene: Keap1 / 42062
• FlyBaseID: FBgn0038475
• Length: 776
• Species: Drosophila melanogaster
• Sequence 2: NP_878284.2
• Gene: keap1a / 321837
• ZFINID: ZDB-GENE-030131-556
• Length: 601
• Species: Danio rerio
• Alignment Length: 573
• Identity: 242/573 - (42%)
• Similarity: 344/573 - (60%)
• Gaps: 18/573 - (3%)

  Fly    52 HSTLDDHDATDDDMTFCMSNYAKEALKMMYMMRSHGMLTDVVLEV--KKEL--FPAHKVVLSAAS 112
            |..||          :.:.::..:||:.|..:|.|.||.|:||.|  |.::  |..||:||:|:|
Zfish    26 HGYLD----------YTVESHPSKALQNMDELRHHEMLCDLVLHVTYKDKIVDFKVHKLVLAASS 80

  Fly   113 PYFKAMFTGGLKESEMSRVQLQGVCPTAMSRILYFMYTGQIRVTEVTVCQLLPAATMFQVPNVID 177
            ||||||||...||...|.|.|:.|||..:||::.|.||.:|.|.|..|..:|..|..:|:..|..
Zfish    81 PYFKAMFTSNFKECHASEVTLRDVCPQVISRLIDFAYTSRITVGETCVLHVLLTAMRYQMEEVAK 145

  Fly   178 ACCAFLERQLDPTNAIGIAHFAEQHGCVELQKKANVFIERNFTQVCQEEEFLQLSAYQLIALIRR 242
            |||.||.:.|:|:|.|||:.|||:.||.:|..:...:|..:|.:|.:||||..||..||:.||.:
Zfish   146 ACCDFLMKNLEPSNVIGISRFAEEIGCTDLHLRTREYINTHFNEVTKEEEFFSLSHCQLLELISQ 210

  Fly   243 DELNVQEEREVYNAVLKWVKYDEDNRHCKMEHILGAVRCQFLTPNFLKEQMKNCDVLRKVPACRE 307
            |.|.|..|.|||.|.:.||::|.::|......:|.||....|.|.|||.|:::|.:|.|..:|::
Zfish   211 DSLKVLCESEVYKACIDWVRWDAESRAQYFHALLNAVHIYALPPTFLKRQLQSCPILSKANSCKD 275

  Fly   308 YLAKIFKDLTLHK-CPGVKERTPNTTRMIFVAGGFFRHSLDILEAYNVDDMTWTTLANLRIPRSG 371
            :|:|||.::.|.| .|....|   .|::|::|||:.:||||.|||::.....|..|.::..|.||
Zfish   276 FLSKIFHEMALRKPLPPTPHR---GTQLIYIAGGYKQHSLDTLEAFDPHKNVWLKLGSMMSPCSG 337

  Fly   372 LGAAFLKGKFYAVGGRNNNIGSSYDSDWVDRYSAVTETWRPCAPMSVPRHRVGVAVMDELMYAVG 436
            |||..|.|..|.|||||.::.::.:|..:..|:.:|..|...||::.||:||||.|:|..:||||
Zfish   338 LGACVLFGLLYTVGGRNLSLQNNTESGSLSCYNPMTNQWTQLAPLNTPRNRVGVGVIDGSIYAVG 402

  Fly   437 GSAGMEYHNTVEYYDPDLDRWTLVQPMHAKRLGVGVVVVNRLLYAIGGFDGNERLASVECYHPEN 501
            ||....:||:||.|||:.:|||.|.||...|||.||......||.:|||||:.|..:||.|.|:.
Zfish   403 GSHASTHHNSVERYDPETNRWTFVAPMSVARLGAGVAACGGCLYVVGGFDGDNRWNTVERYQPDT 467

  Fly   502 NEWSFLPPLQTGRSGAGVAAINQYIYVVGGFDGTRQLATVERYDTENDTWDMVAPIQIARSALSL 566
            |.|..:.|:.|.|||.||..::.|:|.|||:||..||.|:|||:...|.|:.:|.:...|||..:
Zfish   468 NTWQHVAPMNTVRSGLGVVCMDNYLYAVGGYDGQTQLKTMERYNITRDVWEPMASMNHCRSAHGV 532

  Fly   567 TPLDEKLYAIGGFDGNNFLSIVEVYDPRTNTWTTGTPLKSGRSGHASAVIYQP 619
            :....|::.:|||:...|||.||.|.|.:|.||..|.:..||||...||..:|
Zfish   533 SVYQCKIFVLGGFNQGGFLSSVECYCPASNVWTLVTDMPVGRSGMGVAVTMEP 585

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Keap1	NP_732202.2	PHA03098	92..599	CDD:222983	221/511 (43%)
		KELCH repeat	369..416	CDD:276965	18/46 (39%)
		KELCH repeat	420..463	CDD:276965	24/42 (57%)
		KELCH repeat	467..510	CDD:276965	19/42 (45%)
		KELCH repeat	514..558	CDD:276965	21/43 (49%)
		KELCH repeat	561..606	CDD:276965	18/44 (41%)
keap1a	NP_878284.2	BTB_POZ_KLHL19_KEAP1	33..156	CDD:349557	53/122 (43%)
		PHA03098	54..571	CDD:222983	225/519 (43%)
		Kelch 1. /evidence=ECO:0000255	292..337		16/47 (34%)
		KELCH repeat	336..382	CDD:276965	18/45 (40%)
		Kelch 2. /evidence=ECO:0000255	338..388		19/49 (39%)
		KELCH repeat	386..429	CDD:276965	24/42 (57%)
		Kelch 3. /evidence=ECO:0000255	389..435		25/45 (56%)
		KELCH repeat	433..477	CDD:276965	20/43 (47%)
		Kelch 4. /evidence=ECO:0000255	436..482		19/45 (42%)
		KELCH repeat	480..525	CDD:276965	21/44 (48%)
		Kelch 5. /evidence=ECO:0000255	484..529		19/44 (43%)
		KELCH repeat	527..572	CDD:276965	18/44 (41%)
		Kelch 6. /evidence=ECO:0000255	530..576		17/45 (38%)