Protein Alignment Keap1 and KLHL10

DIOPT Version :10

• Sequence 1: NP_732202.2
• Gene: Keap1 / 42062
• FlyBaseID: FBgn0038475
• Length: 776
• Species: Drosophila melanogaster
• Sequence 2: NP_689680.2
• Gene: KLHL10 / 317719
• HGNCID: 18829
• Length: 608
• Species: Homo sapiens
• Alignment Length: 557
• Identity: 187/557 - (33%)
• Similarity: 293/557 - (52%)
• Gaps: 25/557 - (4%)

  Fly    76 ALKMMYMMRSHGMLTDVVLEVKKELFPAHKVVLSAASPYFKAMFTGGLKESEMSRVQLQGVCPTA 140
            |.::...:|..|.|.|||::|....|.|||.:|.:.|.||:|:||.|...:|.....:.|:.|..
Human    25 ACEIFNELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEKKVYNIPGISPDM 89

  Fly   141 MSRILYFMYTGQIRVTEVTVCQLLPAATMFQVPNVIDACCAFLERQLDPTNAIGIAHFAEQHGCV 205
            |..|:.:.||..:.:|...|.:||.||..|.:..::..||.||:.:|...|.|||..|.:.:.|.
Human    90 MKLIIEYAYTRTVPITPDNVEKLLAAADQFNIMGIVRGCCEFLKSELCLDNCIGICKFTDYYYCP 154

  Fly   206 ELQKKANVFIERNFTQVCQ-EEEFLQLSAYQLIALIRRDELNVQEEREVYNAVLKWVKYDEDNRH 269
            ||::||.:||..||.::.: ..|||:||..:|..:|.:|||||::|..|:.|:|||:.:|..||.
Human   155 ELRQKAYMFILHNFEEMVKVSAEFLELSVTELKDIIEKDELNVKQEDAVFEAILKWISHDPQNRK 219

  Fly   270 CKMEHILGAVRCQFLTPNFLKEQMKNCDVLRKVPACREYLAKIFK---DLTLHKCPGVKERTPNT 331
            ..:..:|..||...:...:....:|..|.::....|:..:....|   ||.::. |...:.|...
Human   220 QHISILLPKVRLALMHAEYFMNNVKMNDYVKDSEECKPVIINALKAMYDLNMNG-PSNSDFTNPL 283

  Fly   332 TR------MIFVAGGFFRHS-LDILEAYNVDDMTWTTL-ANLRIPRSGLGAAFLKGKFYAVGGRN 388
            ||      ::|..||:...| .:.:|||:.....|..: .....||:..|||:|||..|.:||
Human   284 TRPRLPYAILFAIGGWSGGSPTNAIEAYDARADRWVNVTCEEESPRAYHGAAYLKGYVYIIGG-- 346

  Fly   389 NNIGSSYDS-DW---VDRYSAVTETWRPCAPMSVPRHRVGVAVMDELMYAVGGSAGMEYHNTVEY 449
                  :|| |:   |.|:..|.:||...|||...|..|.|.|:...:||:||..|....||.|.
Human   347 ------FDSVDYFNSVKRFDPVKKTWHQVAPMHSRRCYVSVTVLGNFIYAMGGFDGYVRLNTAER 405

  Fly   450 YDPDLDRWTLVQPMHAKRLGVGVVVVNRLLYAIGGFDGNERLASVECYHPENNEWSFLPPLQTGR 514
            |:|:.::|||:.|||.:|.......:...:|..|||:|||.|.:.|.|:.|:|:|:.:.|:::.|
Human   406 YEPETNQWTLIAPMHEQRSDASATTLYGKVYICGGFNGNECLFTAEVYNTESNQWTVIAPMRSRR 470

  Fly   515 SGAGVAAINQYIYVVGGFDGTRQLATVERYDTENDTWDMVAPIQIARSALSLTPLDEKLYAIGGF 579
            ||.||.|..:::|.||||||..:|.:.|.|....:||..:..:...||...:..:|:.|:.:|||
Human   471 SGIGVIAYGEHVYAVGGFDGANRLRSAEAYSPVANTWRTIPTMFNPRSNFGIEVVDDLLFVVGGF 535

  Fly   580 DGNNFLSIVEVYDPRTNTWTTGTPLKSGRSGHASAVI 616
            :|......||.||.:|:.|.....:...||..:..|:
Human   536 NGFTTTFNVECYDEKTDEWYDAHDMSIYRSALSCCVV 572

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Keap1	NP_732202.2	PHA03098	92..599	CDD:222983	178/522 (34%)
		KELCH repeat	369..416	CDD:276965	19/50 (38%)
		KELCH repeat	420..463	CDD:276965	17/42 (40%)
		KELCH repeat	467..510	CDD:276965	14/42 (33%)
		KELCH repeat	514..558	CDD:276965	18/43 (42%)
		KELCH repeat	561..606	CDD:276965	14/44 (32%)
KLHL10	NP_689680.2	PHA03098	36..572	CDD:222983	184/544 (34%)
		Kelch 1	292..339		14/46 (30%)
		KELCH repeat	329..372	CDD:276965	19/50 (38%)
		Kelch 2	340..386		18/53 (34%)
		KELCH repeat	376..420	CDD:276965	18/43 (42%)
		Kelch 3	388..433		17/44 (39%)
		KELCH repeat	423..466	CDD:276965	14/42 (33%)
		Kelch 4	434..480		20/45 (44%)
		KELCH repeat	470..513	CDD:276965	18/42 (43%)
		Kelch 5	481..527		14/45 (31%)
		KELCH repeat	517..561	CDD:276965	14/43 (33%)
		Kelch 6	529..574		14/44 (32%)