Protein Alignment Keap1 and Klhl31

DIOPT Version :10

• Sequence 1: NP_732202.2
• Gene: Keap1 / 42062
• FlyBaseID: FBgn0038475
• Length: 776
• Species: Drosophila melanogaster
• Sequence 2: NP_001101640.1
• Gene: Klhl31 / 315833
• RGDID: 1560540
• Length: 634
• Species: Rattus norvegicus
• Alignment Length: 646
• Identity: 152/646 - (23%)
• Similarity: 265/646 - (41%)
• Gaps: 79/646 - (12%)

  Fly    27 RPEEAEMSNTSESCSI----SCGGRFGSAHS-TLDDHDATDDDMTFCMSNYAKEALKMMYMMRSH 86
            :||..||:...|...:    :..|..|..:| :....:.||       ::|....|:.:..||..
  Rat    12 KPEINEMTIIVEDSPLNKLNALNGLLGGENSLSCVSSELTD-------TSYGPNLLEGLSKMRQE 69

  Fly    87 GMLTDVVLEVKKELFPAHKVVLSAASPYFKAMFTGGLKESEMSRVQLQGVCPTAMSRILYFMYTG 151
            ..|.|:|:..|.:.|..||.|:::.|.||..:..   .:....||.|..:.|..::.::.:.|||
  Rat    70 SFLCDLVIGTKTKSFDVHKSVMASCSEYFYNILK---NDPSTKRVDLNDIAPLGLATVIAYAYTG 131

  Fly   152 QIRVTEVTVCQLLPAATMFQVPNVIDACCAFLERQLDPTNAIGIAHFAEQHGCVELQKKANVFIE 216
            ::.::..|:..::.||...|:..::..|..||.|::...|.:.:.:.||.:.....:..|..||.
  Rat   132 KLTLSLYTIGSIISAAVYLQIHTLVKMCSDFLIREISVENCMYVVNMAETYCLKNAKATAQKFIR 196

  Fly   217 RNFTQVCQEEEFLQLSAYQLIALIRRDELNVQEEREVYNAVLKWVKYDEDNRHCKMEHI------ 275
            .||.:....|:|::|:..|:..|:..|:|.:..|...:...:||:::|:.    :::|.
  Rat   197 DNFIEFADSEQFMKLTFEQINELLIDDDLQLPSELVAFQIAMKWIEFDQK----RVKHAADLLSN 257

  Fly   276 --LGAVRCQFLTPNFLK---EQMKNCDVLRKVPACREYLAKIFKDLTLHKCPGVKERTPNTTRMI 335
              .|.:..|.|. |:::   ..|::.|..:.:.....|....:...||.   ..:.|.....|::
  Rat   258 IRFGTISAQDLV-NYVQTVPRMMQDADCHKLLVDAMNYHLLPYHQNTLQ---SRRTRIRGGCRVL 318

  Fly   336 FVAG---GFFRHSL--DILEAYNVDDMTWTTLANLRIPRSGLGAAFLKGKFYAVGGRNNNIGSSY 395
            ...|   |....||  |:|  |...:..|:.|..:.........|.:.|..|..||.:.|...:.
  Rat   319 ITVGGRPGLTEKSLSRDVL--YRDPENGWSKLTEMPAKSFNQCVAVMDGFLYVAGGEDQNDARNQ 381

  Fly   396 DSDWVD---RYSAVTETWRPCAPMSVPRHRVGVAVMDELMYAVGGSAGMEYHNTVEYYDPDLDRW 457
            ....|.   ||.....||.....|:..|....::|.:.|:|||||........::|.|.|..::|
  Rat   382 AKHAVSNFCRYDPRFNTWIHLGSMNQKRTHFSLSVFNGLLYAVGGRNAEGSLASLECYVPSTNQW 446

  Fly   458 TLVQPM------HAKRLGVGVVVVNRLLYAIGGFDGNERLASVECYHPENNEWSFLPPLQTGRSG 516
            ....|:      ||..:..|.|:|.      ||:.|:....||..|.|..:.|..||.|.|.|..
  Rat   447 QPKAPLEVARCCHASAVADGRVIVT------GGYIGSAYSRSVCAYDPALDAWQELPGLSTPRGW 505

  Fly   517 AGVAAINQYIYVVGGFD----GTR-QLATVERYDTENDTWDMVAPIQIARSALSLTPLDEKLYAI 576
            ....|:...:||:||..    |.| .:.|||.:......|..|||:.:..|...::.|..:.|.:
  Rat   506 HCSVALGDRVYVMGGSQLGPRGERVDVLTVESFSPVARQWSFVAPLPVGVSTAGVSALHGRAYLV 570

  Fly   577 GGFD--GNNFLSIVEVYDPRTNTW----------------TTGTPLKSGRSGHASAVIYQP 619
            ||::  ...:...::.::|..|.|                |...|....|...||:|...|
  Rat   571 GGWNEGEKKYKKCIQCFNPELNEWMEDDELPEATVGVSCCTLAMPNSVSRESRASSVSSVP 631

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Keap1	NP_732202.2	PHA03098	92..599	CDD:222983	129/554 (23%)
		KELCH repeat	369..416	CDD:276965	11/49 (22%)
		KELCH repeat	420..463	CDD:276965	12/42 (29%)
		KELCH repeat	467..510	CDD:276965	13/42 (31%)
		KELCH repeat	514..558	CDD:276965	15/48 (31%)
		KELCH repeat	561..606	CDD:276965	10/62 (16%)
Klhl31	NP_001101640.1	BTB_POZ_KLHL31_KBTBD1	55..174	CDD:349569	31/121 (26%)
		PHA03098	73..601	CDD:222983	130/546 (24%)
		BACK	167..264	CDD:475122	21/100 (21%)
		KELCH repeat	356..405	CDD:276965	11/48 (23%)
		KELCH repeat	409..453	CDD:276965	13/43 (30%)
		KELCH repeat	456..501	CDD:276965	16/50 (32%)
		KELCH repeat	503..553	CDD:276965	15/49 (31%)
		KELCH repeat	555..602	CDD:276965	8/46 (17%)