DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Keap1 and Klhl28

DIOPT Version :9

Sequence 1:	NP_732202.2	Gene:	Keap1 / 42062	FlyBaseID:	FBgn0038475	Length:	776	Species:	Drosophila melanogaster
Sequence 2:	NP_001100205.1	Gene:	Klhl28 / 299103	RGDID:	1311326	Length:	571	Species:	Rattus norvegicus

Alignment Length:	561	Identity:	195/561 - (34%)
Similarity:	294/561 - (52%)	Gaps:	28/561 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 DHDATDDDMTFCMSN----YAKEALKMMYMMRSHGMLTDVVLEVKKELFPAHKVVLSAASPYFKA 117
            ||.|.    |:.::|    ::::.|:.:.::|.|..|.|::|.|......||||||::.||||||
  Rat     2 DHTAP----TYMLANLTHLHSEQLLQGLNLLRQHHELCDIILRVGDVKIHAHKVVLASISPYFKA 62

  Fly   118 MFTGGLKESEMSRVQLQGVCPTAMSRILYFMYTGQIRVTEVTVCQLLPAATMFQVPNVIDACCAF 182
            ||||.|.|.|.|.|:.|.:...|:..|:.:.|||.:.:::.||..|||||.:.|:..|:..||.|
  Rat    63 MFTGNLSEKENSEVEFQCIDEAALQAIVEYAYTGTVFISQDTVESLLPAANLLQIKLVLKECCTF 127

  Fly   183 LERQLDPTNAIGIAHFAEQHGCVELQKKANVFIERNFTQVCQEEEFLQLSAYQLIALIRRDELNV 247
            ||.||||.|.|||:.|||.:||.:|...|..||.:||..|||.|||.:|:...|..::..|.|||
  Rat   128 LESQLDPGNCIGISRFAETYGCHDLYLAATKFICQNFESVCQTEEFFELTHGDLDEIVSNDCLNV 192

  Fly   248 QEEREVYNAVLKWVKYDEDNRHCKMEHILGAVRCQFLTPNFLKEQMKNCDVLRKVPACREYLAKI 312
            ..|..|:.|:..|:|||...|...:..:|.:||...|:..||....:...::|....|:..|.:.
  Rat   193 ATEETVFYALESWIKYDVQERQKYLAQLLNSVRLPLLSVKFLTRLYEANHLIRDDRTCKHLLNEA 257

  Fly   313 FKDLTLHKCP--GVKERTPNTTR-------MIFVAG--GFFRHSLDILEAYNVDDMTWTTLANLR 366
            .|   .|..|  .:..:|...||       :..|.|  |.|. .||.:|.|...:.:|..||.|.
  Rat   258 LK---YHFMPEHRLSHQTVLMTRPRCAPKVLCAVGGKSGLFA-CLDSVEMYFPQNDSWIGLAPLN 318

  Fly   367 IPRSGLGAAFLKGKFYAVGGRNNNIGSSY----DSDWVDRYSAVTETWRPCAPMSVPRHRVGVAV 427
            |||...|...|..|.|.:||...::....    ..:.|:.::..|.||.....|:..|..:||.|
  Rat   319 IPRYEFGICVLDQKVYVIGGIETSVRPGVTVRKHENSVECWNPDTNTWTSLERMNESRSTLGVVV 383

  Fly   428 MDELMYAVGGSAGMEYHNTVEYYDPDLDRWTLVQPMHAKRLGVGVVVVNRLLYAIGGFDGNERLA 492
            :...:||:||..|..|..:||.|.|.:.:|..|.||...|......|::.::|||||: |...:.
  Rat   384 LAGEVYALGGYDGQSYLQSVEKYIPKIRQWQPVAPMTTTRSCFAAAVLDGMIYAIGGY-GPAHMN 447

  Fly   493 SVECYHPENNEWSFLPPLQTGRSGAGVAAINQYIYVVGGFDGTRQLATVERYDTENDTWDMVAPI 557
            |||.|.|..:.|..:..:...|...||..:..:|:||||.:|...|:::||||...:.|.:..|:
  Rat   448 SVERYDPSKDSWETVASMADKRIHFGVGVMLGFIFVVGGHNGVSHLSSIERYDPHQNQWTVCRPM 512

  Fly   558 QIARSALSLTPLDEKLYAIGGFDGNNFLSIVEVYDPRTNTW 598
            :..|:.:....:|..||.:||..|:::|:.|:.|||.::||
  Rat   513 KEPRTGVGAAVIDNYLYVVGGHSGSSYLNTVQKYDPISDTW 553

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Keap1	NP_732202.2	BTB	80..183	CDD:279045	44/102 (43%)
		PHA03098	92..599	CDD:222983	185/522 (35%)
		BACK	192..294	CDD:285009	40/101 (40%)
		Kelch	335..379	CDD:128874	17/45 (38%)
		KELCH repeat	369..416	CDD:276965	11/50 (22%)
		Kelch	382..430	CDD:128874	12/51 (24%)
		KELCH repeat	420..463	CDD:276965	16/42 (38%)
		Kelch	433..476	CDD:128874	16/42 (38%)
		KELCH repeat	467..510	CDD:276965	14/42 (33%)
		Kelch	478..523	CDD:128874	15/44 (34%)
		KELCH repeat	514..558	CDD:276965	16/43 (37%)
		Kelch_1	514..556	CDD:279660	15/41 (37%)
		KELCH repeat	561..606	CDD:276965	14/38 (37%)
		Kelch	572..616	CDD:128874	12/27 (44%)
Klhl28	NP_001100205.1	PHA03098	35..553	CDD:222983	184/522 (35%)
		KELCH repeat	321..372	CDD:276965	11/50 (22%)
		KELCH repeat	376..419	CDD:276965	16/42 (38%)
		KELCH repeat	423..465	CDD:276965	14/42 (33%)
		KELCH repeat	469..513	CDD:276965	16/43 (37%)
		KELCH repeat	516..559	CDD:276965	14/38 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4441
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D312716at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820