DRSC/TRiP Functional Genomics Resources

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Protein Alignment Keap1 and Klhl25

DIOPT Version :9

Sequence 1:NP_732202.2 Gene:Keap1 / 42062 FlyBaseID:FBgn0038475 Length:776 Species:Drosophila melanogaster
Sequence 2:NP_001034095.1 Gene:Klhl25 / 293023 RGDID:1310815 Length:589 Species:Rattus norvegicus


Alignment Length:579 Identity:170/579 - (29%)
Similarity:258/579 - (44%) Gaps:35/579 - (6%)


- Green bases have known domain annotations that are detailed below.


  Fly    50 SAHSTLDDHDATD--DDMTFCMSNYAKEALKMMYMMRSHGMLTDVVLEVKKELFPAHKVVLSAAS 112
            |.|.|.....:|.  :...|..:::....|..:..:|.|.|.|||.|......||.|:.||:|:|
  Rat     4 SVHETRKSRSSTGSMNISVFHKASHPDCVLAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASS 68

  Fly   113 PYFKAMFTGGLKESEMSRVQLQ-GVCPTAMSRILYFMYTGQIRVTEVTVCQLLPAATMFQVPNVI 176
            .||:|||:.||:||....|..| .:.|..:..:|.|.|:.:|.:.|.....||.|..|.|..:|.
  Rat    69 RYFEAMFSHGLRESRDDTVNFQDNLHPEVLELLLDFAYSSRIVINEENAESLLEAGDMLQFHDVR 133

  Fly   177 DACCAFLERQLDPTNAIGIAHFAEQHGCVELQKKANVFIERNFTQVCQEEEFLQLSAYQLIALIR 241
            ||...|||:.|.|:|.:|:...::.|.|..|.:.:......:|..|.|.|:|..||...|:.||.
  Rat   134 DAAAEFLEKNLSPSNCLGMMVLSDAHQCRRLYEFSCRMSLVHFETVRQSEDFNSLSRDTLLDLIS 198

  Fly   242 RDELNVQEEREVYNAVLKWVKYDEDNRHCKMEHILGAVRCQFLTPNFLKEQMKNCDVLRKVPACR 306
            ||||..::||.|:.|:|:|||:|.:.|...:..:|..||...|..:.||:.:.. :.|.....|.
  Rat   199 RDELETEDERVVFEAILQWVKHDLEQRKVHLPLLLRNVRLALLPSDCLKKAVSG-EALLMADECT 262

  Fly   307 EYL--------AKIFKDLTLHKCPGVKERTPNTTRMIFVAGGFFRHSLDILEAYNVDDMTWTTL- 362
            :.:        .||..:..:...|..:.|....|.:|.....|....:     |.||......: 
  Rat   263 KLIIDEAFRCKTKILLNDGVVTSPFARPRKAGHTLLILGGQTFMCDKI-----YQVDHKAKEIIP 322

  Fly   363 -ANLRIPRSGLGAAFLKGKFYAVGGRNNNIGSSYDSDWVDRYSAVTETWRPCAPMSVPRHRVGVA 426
             |:|..||....|:.:..|.|..|||.:..|.|.|. ||  |..|.|.|...|||.:.|...|.|
  Rat   323 KADLPSPRKEFSASAIGCKVYVTGGRGSENGVSKDV-WV--YDTVHEEWSKAAPMLIARFGHGSA 384

  Fly   427 VMDELMYAVGGSAGME---------YHNTVEYYDPDLDRWTLVQPMHAKRLGVGVVVVNRLLYAI 482
            .::..:|.|||...:.         ....||.|||..::||:|.||........||.....|:..
  Rat   385 ELENCLYVVGGHTSLAGIFPASPSVSLKQVEKYDPGDNKWTMVAPMRDGVSNAAVVSAKLKLFVF 449

  Fly   483 GGFD-GNERLASVECYHPENNEWSFLPPLQTGRSGAGVAAINQYIYVVGGFDGTRQLATVERYDT 546
            ||.. ..:.::.|:|:.|.:|.|:..............|.:...|:::|| |.....|:..|:|.
  Rat   450 GGTSIHRDMVSKVQCFDPSDNRWTIKAECPQPWRYTAAAVLGSQIFIMGG-DTEYTAASAYRFDC 513

  Fly   547 ENDTWDMVAPIQIARSALSLTPLDEKLYAIGGFDGNNFLSIVEVYDPRTNTWT--TGTP 603
            |.:.|..:..:...|.:........|||.:||:.|......::.|||.::||.  |..|
  Rat   514 ETNQWTRIGDMTAKRMSCHAVASGNKLYVVGGYFGTQRCKTLDCYDPTSDTWNCITSVP 572

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Keap1NP_732202.2 BTB 80..183 CDD:279045 39/103 (38%)
PHA03098 92..599 CDD:222983 156/527 (30%)
BACK 192..294 CDD:285009 34/101 (34%)
Kelch 335..379 CDD:128874 10/45 (22%)
KELCH repeat 369..416 CDD:276965 17/46 (37%)
Kelch 382..430 CDD:128874 19/47 (40%)
KELCH repeat 420..463 CDD:276965 15/51 (29%)
Kelch 433..476 CDD:128874 16/51 (31%)
KELCH repeat 467..510 CDD:276965 10/43 (23%)
Kelch 478..523 CDD:128874 9/45 (20%)
KELCH repeat 514..558 CDD:276965 10/43 (23%)
Kelch_1 514..556 CDD:279660 10/41 (24%)
KELCH repeat 561..606 CDD:276965 14/45 (31%)
Kelch 572..616 CDD:128874 13/34 (38%)
Klhl25NP_001034095.1 BTB_POZ_KLHL25 24..151 CDD:349563 46/126 (37%)
PHA03098 39..566 CDD:222983 161/536 (30%)
Kelch 1 296..340 11/48 (23%)
KELCH repeat 330..374 CDD:276965 17/46 (37%)
Kelch 2 341..388 20/49 (41%)
KELCH repeat 378..431 CDD:276965 16/52 (31%)
Kelch 3 389..444 16/54 (30%)
KELCH repeat 434..480 CDD:276965 10/45 (22%)
Kelch 4 446..492 9/45 (20%)
KELCH repeat 482..525 CDD:276965 10/43 (23%)
Kelch 5 493..538 10/45 (22%)
KELCH repeat 528..573 CDD:276965 14/45 (31%)
Kelch 6 539..585 13/34 (38%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4441
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D312716at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X9
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
54.820

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