DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Keap1 and Klhl8

DIOPT Version :9

Sequence 1:	NP_732202.2	Gene:	Keap1 / 42062	FlyBaseID:	FBgn0038475	Length:	776	Species:	Drosophila melanogaster
Sequence 2:	NP_001099465.1	Gene:	Klhl8 / 289457	RGDID:	1304685	Length:	621	Species:	Rattus norvegicus

Alignment Length:	632	Identity:	185/632 - (29%)
Similarity:	313/632 - (49%)	Gaps:	52/632 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 RPEEAEMSNTSESCSISCGGRFGSAHSTLDDHDATDDDMTFCMSNYAKEALKMMYMMRSHGMLTD 91
            |.::.:....|.|....|.|               ||...|..:...|:....:.....:|.|.|
  Rat    20 RQQQQQQQVRSRSSVSECDG---------------DDSFIFEANEAWKDFHGSLLGFYENGELCD 69

  Fly    92 VVLEVKKELFPAHKVVLSAASPYFKAMFTGGLKESEMSRVQLQGVCPTAMSRILYFMYTGQIRVT 156
            |.|:|..:|...||:.|:...|||:|||...:.|::.:.::::.....|:..::.|:|:.::.:|
  Rat    70 VTLKVGSKLISCHKLALACVIPYFRAMFLSEMSEAKQALIEIRDFDGDAVEDLVKFVYSSRLTLT 134

  Fly   157 EVTVCQLLPAATMFQVPNVIDACCAFLERQLDPTNAIGIAHFAEQHGCVELQKKANVFIERNFTQ 221
            ...|..||.||.:.||..|..|||.:::....|:|.:.:..|||.|...:|...|:.:...:||:
  Rat   135 VDNVQPLLYAACILQVELVARACCEYMKLHFHPSNCLAVRAFAESHNRTDLMDMADQYACEHFTE 199

  Fly   222 VCQEEEFLQLSAYQLIALIRRDELNVQEEREVYNAVLKWVKYDEDNRHCKMEHILGAVRCQFLTP 286
            |.:.|:|:.:|...|..|:...:||:..|::||:|.:||:..:..:....::..|..||...|..
  Rat   200 VVECEDFVSVSPQHLHKLLSSSDLNIDSEKQVYSAAIKWLLANPQHHPKWLDETLAQVRLPLLPV 264

  Fly   287 NFLKEQMKNCDVLRKVPACREYLAKIFKDLTLH----KCPGVK---ERTP--NTTRMIFVAGGF- 341
            :||...:....::::...||:.|.:. ::..||    ..|..:   ..||  :|..::|..||.
  Rat   265 DFLMGVVAKEQIVKQNLKCRDLLDEA-RNYHLHLSSKPVPDFEYSVRTTPRKHTAGVLFCVGGRG 328

  Fly   342 -----FRHSLDILEAYNVDDMTWTTLANLRIPRSGLGAAFLKGKFYAVGGR--NNNIGSSYDSDW 399
                 ||.    :|.|:::..:|.....:...|..:|...::||.|||||.  |.::||
  Rat   329 GSGDPFRS----IECYSINTNSWFFGPEMNSRRRHVGVISVEGKVYAVGGHDGNEHLGS------ 383

  Fly   400 VDRYSAVTETWRPCAPMSVPRHRVGVAVMDELMYAVGGSAGMEYHNTVEYYDPDLDRWTLVQPMH 464
            ::.:..:|..|...|.|:..|..:.:|.:...:||:||.......:.||.||.:.|:|:.|.||:
  Rat   384 MEMFDPLTNKWMVKASMNTKRRGIALASLGGPIYAIGGLDDNTCFSDVERYDIESDQWSTVAPMN 448

  Fly   465 AKRLGVGVVVVNRLLYAIGGFDGNERLASVECYHPENNEWSFLPPLQTGRSGAGVAAINQYIYVV 529
            ..|.|||.|.:...:||:||.||...|:|||.|||..::|..:..:...|:|.||:.::..:|||
  Rat   449 TPRGGVGSVALINHVYAVGGNDGVASLSSVERYHPHLDKWVEVKEMGQRRAGNGVSELHGCLYVV 513

  Fly   530 GGFDGTRQLATVERYDTENDTWDMVAPIQIARSALSLTPLDEKLYAIGGFDGNNFLSIVEVYDPR 594
            ||||....|::|||||..::.||.||.:...|..:.:..:..|::|:||.:||.:|:.||.:||.
  Rat   514 GGFDDNSPLSSVERYDPRSNKWDYVAALTTPRGGVGIATVMGKIFAVGGHNGNAYLNTVEAFDPV 578

  Fly   595 TNTWTTGTPLKSGRSGHASAVIYQPACSTTFMDYEDSDAPHPDGSNN 641
            .|.|....|:...|:|...||.   .|.|:    :..|..|  ||.|
  Rat   579 LNKWELVGPVSHCRAGAGVAVC---DCLTS----QIRDVGH--GSTN 616

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Keap1	NP_732202.2	BTB	80..183	CDD:279045	32/102 (31%)
		PHA03098	92..599	CDD:222983	160/523 (31%)
		BACK	192..294	CDD:285009	28/101 (28%)
		Kelch	335..379	CDD:128874	10/49 (20%)
		KELCH repeat	369..416	CDD:276965	15/48 (31%)
		Kelch	382..430	CDD:128874	14/49 (29%)
		KELCH repeat	420..463	CDD:276965	13/42 (31%)
		Kelch	433..476	CDD:128874	18/42 (43%)
		KELCH repeat	467..510	CDD:276965	19/42 (45%)
		Kelch	478..523	CDD:128874	18/44 (41%)
		KELCH repeat	514..558	CDD:276965	21/43 (49%)
		Kelch_1	514..556	CDD:279660	20/41 (49%)
		KELCH repeat	561..606	CDD:276965	15/44 (34%)
		Kelch	572..616	CDD:128874	17/43 (40%)
Klhl8	NP_001099465.1	BTB	58..162	CDD:279045	32/103 (31%)
		PHA03098	61..536	CDD:222983	146/485 (30%)
		BACK	170..272	CDD:285009	28/101 (28%)
		Kelch	320..367	CDD:128874	10/50 (20%)
		KELCH repeat	357..400	CDD:276965	15/48 (31%)
		Kelch	368..414	CDD:128874	15/51 (29%)
		KELCH repeat	404..448	CDD:276965	14/43 (33%)
		Kelch	416..459	CDD:128874	18/42 (43%)
		KELCH repeat	451..496	CDD:276965	19/44 (43%)
		Kelch	462..508	CDD:128874	18/45 (40%)
		KELCH repeat	498..543	CDD:276965	21/44 (48%)
		Kelch	509..555	CDD:128874	18/45 (40%)
		KELCH repeat	545..587	CDD:276965	14/41 (34%)
		Kelch	556..601	CDD:128874	18/47 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4441
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D312716at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820