Protein Alignment Keap1 and Ivns1abp

DIOPT Version :10

• Sequence 1: NP_732202.2
• Gene: Keap1 / 42062
• FlyBaseID: FBgn0038475
• Length: 776
• Species: Drosophila melanogaster
• Sequence 2: NP_001388271.1
• Gene: Ivns1abp / 289089
• RGDID: 1306290
• Length: 642
• Species: Rattus norvegicus
• Alignment Length: 639
• Identity: 170/639 - (26%)
• Similarity: 270/639 - (42%)
• Gaps: 106/639 - (16%)

  Fly    63 DDMTFCMSNYAKEALKMMYMMRSHGMLTDVVLEVKKELFPAHKVVLSAASPYFKAMFTGGLKESE 127
            :|..|..|:.||     :..:|..|...||.|:|......||:.||:..|||...:|........
  Rat    10 EDENFIESSVAK-----LNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIFNSDSDPHG 69

  Fly   128 MSRVQLQGVCPTAMSRILYFMYTGQIRVTEVTVCQLLPAATMFQVPNVIDACCAFLERQLDPTNA 192
            :|.|:|..:.|.|:..:|.:.||.|::..:..|..:..||...::..|...|..:|..::|.|:.
  Rat    70 VSHVKLDDLNPEAVEVLLNYAYTAQLKADKELVKDVYSAAKKLKMDRVKQVCGDYLLSRMDVTSC 134

  Fly   193 IGIAHFAEQHGCVELQKKANVFIERNFTQVCQEEEFLQLSAYQLIALIRRDELNVQEEREVYNAV 257
            |...:||...|...|..|.:.:|:.:..|:.:|||||:|...:|..:: .|.:.:....::|..|
  Rat   135 ISYRNFASCMGDSRLLNKVDAYIQEHLLQISEEEEFLKLPRLKLEVML-EDNVCLPSNGKLYTKV 198

  Fly   258 LKWVK----------------------------------------YDEDNRHCKM---------- 272
            :.||:                                        :..|:.|.:.
  Rat   199 INWVQRSIWENGDSLEELMEEVQTLYYSADHKLLDGNPLDGQAEVFGSDDDHIQFVQKKPPRENG 263

  Fly   273 -EHILGAVRCQFLTPNFLKEQMKN----------------CDVLRKVPACREYL----------- 309
             :.|.|:......:||...:..|:                |..:.....|..:|
  Rat   264 HKQISGSSTGCLSSPNASVQSPKHEWKIVASEKTSNNTYLCLAVLDGTFCVIFLHGRNSPQSSPT 328

  Fly   310 --AKIFKDLTLHKCPG---VKERTP--------NTTRM---IFVAGGFFRHS-LDILEAYNVDDM 357
              .|:.|.|:....|.   .|..:|        .|..|   :..|||:.|.. |..:|.|:....
  Rat   329 STPKLSKSLSFEMQPDELLEKPMSPMQYARSGLGTAEMNGKLIAAGGYNREECLRTVECYDPHTD 393

  Fly   358 TWTTLANLRIPRSGLGAAFLKGKFYAVGGRNNNIGSSYDSDWVDRYSAVTETWRPCAPMSVPRHR 422
            .|:.||.:|.||:....|.|.|:.|.|||.|   |.|.|....:.|....:.|.|...:...|..
  Rat   394 HWSFLAPMRTPRARFQMAVLMGQLYVVGGSN---GHSDDLSCGEMYDPSIDDWTPVPELRTNRCN 455

  Fly   423 VGVAVMDELMYAVGGS--AGMEYHNTVEYYDPDLDRWTLVQPMHAKRLGVGVVVVNRLLYAIGGF 485
            .||..::..:|.||||  .|.:.....:.:||....||...|::.:|....|..:...||.|||.
  Rat   456 AGVCALNGKLYIVGGSDPYGQKGLKNCDVFDPVTKSWTSCAPLNIRRHQSAVCELGGYLYIIGGA 520

  Fly   486 DGNERLASVECYHPENNEWSFLPPLQTGRSGAGVAAINQYIYVVGGFDGTRQLATVERYDTENDT 550
            :....|.:||.|:||||.|:.:.|:...|.|||||.::..::|.|||||:..::.||.||...:.
  Rat   521 ESWNCLNTVERYNPENNTWTLIAPMNVARRGAGVAVLDGKLFVGGGFDGSHAISCVEMYDPTRNE 585

  Fly   551 WDMVAPIQIARSALSLTPLDEKLYAIGGFDGNNFLSIVEVYDPRTNTWTTGTPL 604
            |.|:..:...||...:|.:...:||:||||||.||:.||||:..:|.|:..|.:
  Rat   586 WKMMGNMTSPRSNAGITTVGNTIYAVGGFDGNEFLNTVEVYNLESNEWSPYTKI 639

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Keap1	NP_732202.2	PHA03098	92..599	CDD:222983	160/603 (27%)
		KELCH repeat	369..416	CDD:276965	15/46 (33%)
		KELCH repeat	420..463	CDD:276965	13/44 (30%)
		KELCH repeat	467..510	CDD:276965	16/42 (38%)
		KELCH repeat	514..558	CDD:276965	18/43 (42%)
		KELCH repeat	561..606	CDD:276965	20/44 (45%)
Ivns1abp	NP_001388271.1	BTB_POZ_NS1BP	14..137	CDD:349615	36/127 (28%)
		BACK_NS1BP_IVNS1ABP	129..225	CDD:350577	22/96 (23%)
		NanM	349..627	CDD:442289	96/280 (34%)
		KELCH repeat	358..401	CDD:276965	12/42 (29%)
		KELCH repeat	405..450	CDD:276965	15/47 (32%)
		KELCH repeat	453..498	CDD:276965	13/44 (30%)
		KELCH repeat	502..546	CDD:276965	17/43 (40%)
		KELCH repeat	549..592	CDD:276965	18/42 (43%)
		KELCH repeat	596..635	CDD:276965	19/38 (50%)