DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Keap1 and Ivns1abp

DIOPT Version :9

Sequence 1:	NP_732202.2	Gene:	Keap1 / 42062	FlyBaseID:	FBgn0038475	Length:	776	Species:	Drosophila melanogaster
Sequence 2:	XP_006250050.1	Gene:	Ivns1abp / 289089	RGDID:	1306290	Length:	642	Species:	Rattus norvegicus

Alignment Length:	639	Identity:	170/639 - (26%)
Similarity:	270/639 - (42%)	Gaps:	106/639 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 DDMTFCMSNYAKEALKMMYMMRSHGMLTDVVLEVKKELFPAHKVVLSAASPYFKAMFTGGLKESE 127
            :|..|..|:.||     :..:|..|...||.|:|......||:.||:..|||...:|........
  Rat    10 EDENFIESSVAK-----LNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIFNSDSDPHG 69

  Fly   128 MSRVQLQGVCPTAMSRILYFMYTGQIRVTEVTVCQLLPAATMFQVPNVIDACCAFLERQLDPTNA 192
            :|.|:|..:.|.|:..:|.:.||.|::..:..|..:..||...::..|...|..:|..::|.|:.
  Rat    70 VSHVKLDDLNPEAVEVLLNYAYTAQLKADKELVKDVYSAAKKLKMDRVKQVCGDYLLSRMDVTSC 134

  Fly   193 IGIAHFAEQHGCVELQKKANVFIERNFTQVCQEEEFLQLSAYQLIALIRRDELNVQEEREVYNAV 257
            |...:||...|...|..|.:.:|:.:..|:.:|||||:|...:|..:: .|.:.:....::|..|
  Rat   135 ISYRNFASCMGDSRLLNKVDAYIQEHLLQISEEEEFLKLPRLKLEVML-EDNVCLPSNGKLYTKV 198

  Fly   258 LKWVK----------------------------------------YDEDNRHCKM---------- 272
            :.||:                                        :..|:.|.:.
  Rat   199 INWVQRSIWENGDSLEELMEEVQTLYYSADHKLLDGNPLDGQAEVFGSDDDHIQFVQKKPPRENG 263

  Fly   273 -EHILGAVRCQFLTPNFLKEQMKN----------------CDVLRKVPACREYL----------- 309
             :.|.|:......:||...:..|:                |..:.....|..:|
  Rat   264 HKQISGSSTGCLSSPNASVQSPKHEWKIVASEKTSNNTYLCLAVLDGTFCVIFLHGRNSPQSSPT 328

  Fly   310 --AKIFKDLTLHKCPG---VKERTP--------NTTRM---IFVAGGFFRHS-LDILEAYNVDDM 357
              .|:.|.|:....|.   .|..:|        .|..|   :..|||:.|.. |..:|.|:....
  Rat   329 STPKLSKSLSFEMQPDELLEKPMSPMQYARSGLGTAEMNGKLIAAGGYNREECLRTVECYDPHTD 393

  Fly   358 TWTTLANLRIPRSGLGAAFLKGKFYAVGGRNNNIGSSYDSDWVDRYSAVTETWRPCAPMSVPRHR 422
            .|:.||.:|.||:....|.|.|:.|.|||.|   |.|.|....:.|....:.|.|...:...|..
  Rat   394 HWSFLAPMRTPRARFQMAVLMGQLYVVGGSN---GHSDDLSCGEMYDPSIDDWTPVPELRTNRCN 455

  Fly   423 VGVAVMDELMYAVGGS--AGMEYHNTVEYYDPDLDRWTLVQPMHAKRLGVGVVVVNRLLYAIGGF 485
            .||..::..:|.||||  .|.:.....:.:||....||...|::.:|....|..:...||.|||.
  Rat   456 AGVCALNGKLYIVGGSDPYGQKGLKNCDVFDPVTKSWTSCAPLNIRRHQSAVCELGGYLYIIGGA 520

  Fly   486 DGNERLASVECYHPENNEWSFLPPLQTGRSGAGVAAINQYIYVVGGFDGTRQLATVERYDTENDT 550
            :....|.:||.|:||||.|:.:.|:...|.|||||.::..::|.|||||:..::.||.||...:.
  Rat   521 ESWNCLNTVERYNPENNTWTLIAPMNVARRGAGVAVLDGKLFVGGGFDGSHAISCVEMYDPTRNE 585

  Fly   551 WDMVAPIQIARSALSLTPLDEKLYAIGGFDGNNFLSIVEVYDPRTNTWTTGTPL 604
            |.|:..:...||...:|.:...:||:||||||.||:.||||:..:|.|:..|.:
  Rat   586 WKMMGNMTSPRSNAGITTVGNTIYAVGGFDGNEFLNTVEVYNLESNEWSPYTKI 639

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Keap1	NP_732202.2	BTB	80..183	CDD:279045	28/102 (27%)
		PHA03098	92..599	CDD:222983	160/603 (27%)
		BACK	192..294	CDD:285009	26/152 (17%)
		Kelch	335..379	CDD:128874	15/44 (34%)
		KELCH repeat	369..416	CDD:276965	15/46 (33%)
		Kelch	382..430	CDD:128874	14/47 (30%)
		KELCH repeat	420..463	CDD:276965	13/44 (30%)
		Kelch	433..476	CDD:128874	13/44 (30%)
		KELCH repeat	467..510	CDD:276965	16/42 (38%)
		Kelch	478..523	CDD:128874	21/44 (48%)
		KELCH repeat	514..558	CDD:276965	18/43 (42%)
		Kelch_1	514..556	CDD:279660	18/41 (44%)
		KELCH repeat	561..606	CDD:276965	20/44 (45%)
		Kelch	572..616	CDD:128874	17/33 (52%)
Ivns1abp	XP_006250050.1	BTB_POZ_NS1BP	14..137	CDD:349615	36/127 (28%)
		PHA03098	23..638	CDD:222983	164/618 (27%)
		BACK_NS1BP_IVNS1ABP	129..225	CDD:350577	22/96 (23%)
		KELCH repeat	358..401	CDD:276965	12/42 (29%)
		KELCH repeat	405..450	CDD:276965	15/47 (32%)
		KELCH repeat	453..498	CDD:276965	13/44 (30%)
		KELCH repeat	502..546	CDD:276965	17/43 (40%)
		KELCH repeat	549..592	CDD:276965	18/42 (43%)
		KELCH repeat	596..635	CDD:276965	19/38 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4441
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D312716at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820